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GPA33 glycoprotein A33 [ Homo sapiens (human) ]

Gene ID: 10223, updated on 22-Sep-2022

Summary

Official Symbol
GPA33provided by HGNC
Official Full Name
glycoprotein A33provided by HGNC
Primary source
HGNC:HGNC:4445
See related
Ensembl:ENSG00000143167 MIM:602171; AllianceGenome:HGNC:4445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A33
Summary
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 108.1), duodenum (RPKM 69.2) and 2 other tissues See more
Orthologs
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Genomic context

See GPA33 in Genome Data Viewer
Location:
1q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167052836..167090377, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (166398672..166437547, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167022073..167059614, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene RNA, 5S ribosomal pseudogene 65 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105371600 Neighboring gene Sharpr-MPRA regulatory region 13653 Neighboring gene uncharacterized LOC124904451 Neighboring gene Sharpr-MPRA regulatory region 8817 Neighboring gene serine/threonine/tyrosine interacting like 2 Neighboring gene ribosomal protein S17 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of GPA33 PubMed
Knockdown of glycoprotein A33, transmembrane (GPA33) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of glycoprotein A33 (GPA33) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129986, MGC129987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cell surface A33 antigen
Names
glycoprotein A33 (transmembrane)
transmembrane glycoprotein A33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005814.3NP_005805.1  cell surface A33 antigen precursor

    See identical proteins and their annotated locations for NP_005805.1

    Status: REVIEWED

    Source sequence(s)
    CA307909, U79725
    Consensus CDS
    CCDS1258.1
    UniProtKB/Swiss-Prot
    Q5VZP6, Q99795
    Related
    ENSP00000356842.3, ENST00000367868.4
    Conserved Domains (2) summary
    smart00408
    Location:154218
    IGc2; Immunoglobulin C-2 Type
    pfam07686
    Location:26138
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167052836..167090377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000005.2XP_016855494.1  cell surface A33 antigen isoform X1

  2. XM_047424480.1XP_047280436.1  cell surface A33 antigen isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    166398672..166437547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)