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PRG4 proteoglycan 4 [ Homo sapiens (human) ]

Gene ID: 10216, updated on 8-Dec-2018

Summary

Official Symbol
PRG4provided by HGNC
Official Full Name
proteoglycan 4provided by HGNC
Primary source
HGNC:HGNC:9364
See related
Ensembl:ENSG00000116690 MIM:604283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSF; SZP; CACP; HAPO; JCAP
Summary
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in liver (RPKM 61.2), fat (RPKM 6.6) and 1 other tissue See more
Orthologs

Genomic context

See PRG4 in Genome Data Viewer
Location:
1q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (186296273..186314562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186265405..186283688)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985239 Neighboring gene uncharacterized GS1-204I12.4 Neighboring gene hemicentin 1 Neighboring gene uncharacterized LOC105371654 Neighboring gene RNA, U6 small nuclear 1240, pseudogene Neighboring gene uncharacterized LOC102724919 Neighboring gene translocated promoter region, nuclear basket protein Neighboring gene odr-4 GPCR localization factor homolog Neighboring gene oculomedin Neighboring gene phosducin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ32635, bG174L6.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent conferring compression resistance HDA PubMed 
polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteoglycan 4
Names
articular superficial zone protein
hemangiopoietin
lubricin
megakaryocyte stimulating factor
superficial zone proteoglycan

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008248.2 RefSeqGene

    Range
    4988..23277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127708.2NP_001121180.2  proteoglycan 4 isoform B preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B, also known as V0a) lacks an alternate in-frame exon in the 5' coding region, compared to variant A. The resulting protein (isoform B) is shorter than isoform A.
    Source sequence(s)
    AK131434, AL133553, CA435357, DA977744, KF455089, U70136
    Consensus CDS
    CCDS44288.1
    UniProtKB/Swiss-Prot
    Q92954
    Related
    ENSP00000356453.4, ENST00000367483.8
    Conserved Domains (4) summary
    smart00201
    Location:2567
    SO; Somatomedin B -like domains
    cd00094
    Location:11021362
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cl26247
    Location:258378
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl26464
    Location:333798
    Atrophin-1; Atrophin-1 family
  2. NM_001127709.2NP_001121181.2  proteoglycan 4 isoform C preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C, also known as V2) lacks two alternate in-frame exons in the 5' coding region, compared to variant A. The resulting protein (isoform C) is shorter than isoform A.
    Source sequence(s)
    AK131434, AL133553, CA435357, DA977744, DC404857, KF455089, U70136
    Consensus CDS
    CCDS44287.1
    UniProtKB/Swiss-Prot
    Q92954
    Related
    ENSP00000356455.4, ENST00000367485.4
    Conserved Domains (3) summary
    smart00201
    Location:66108
    SO; Somatomedin B -like domains
    cd00094
    Location:10501310
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam05086
    Location:286349
    Dicty_REP; Dictyostelium (Slime Mold) REP protein
  3. NM_001127710.2NP_001121182.2  proteoglycan 4 isoform D preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D, also known as V3) lacks three alternate in-frame exons in the 5' coding region, compared to variant A. The resulting protein (isoform D) is shorter than isoform A.
    Source sequence(s)
    AK131434, AL133553, CA435357, DA977744, DC295855, KF455089, U70136
    UniProtKB/Swiss-Prot
    Q92954
    Conserved Domains (3) summary
    smart00201
    Location:2567
    SO; Somatomedin B -like domains
    cd00094
    Location:10091269
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam05086
    Location:245308
    Dicty_REP; Dictyostelium (Slime Mold) REP protein
  4. NM_001303232.1NP_001290161.1  proteoglycan 4 isoform E preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E, also known as V1) lacks an alternate in-frame exon in the 5' coding region, compared to variant A. The resulting protein (isoform E) is shorter than isoform A.
    Source sequence(s)
    AL133553, CA435357, DA995681, U70136
    Consensus CDS
    CCDS81411.1
    UniProtKB/Swiss-Prot
    Q92954
    UniProtKB/TrEMBL
    A0A0U1RR20
    Related
    ENSP00000489292.1, ENST00000635041.1
    Conserved Domains (3) summary
    smart00201
    Location:66108
    SO; Somatomedin B -like domains
    cd00094
    Location:11001360
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam05086
    Location:336399
    Dicty_REP; Dictyostelium (Slime Mold) REP protein
  5. NM_005807.4NP_005798.3  proteoglycan 4 isoform A preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A, also known as V0) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AK131434, AL133553, CA435357, DA977744, KF455089, U70136
    Consensus CDS
    CCDS1369.1
    UniProtKB/Swiss-Prot
    Q92954
    Related
    ENSP00000399679.2, ENST00000445192.6
    Conserved Domains (4) summary
    smart00201
    Location:66108
    SO; Somatomedin B -like domains
    cd00094
    Location:11431403
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cl26464
    Location:374839
    Atrophin-1; Atrophin-1 family
    cl27863
    Location:304441
    SSL_OB; Staphylococcal superantigen-like OB-fold domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    186296273..186314562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448707.1XP_024304475.1  proteoglycan 4 isoform X1

    Conserved Domains (4) summary
    smart00201
    Location:66108
    SO; Somatomedin B -like domains
    cd00094
    Location:11431403
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cl26464
    Location:374839
    Atrophin-1; Atrophin-1 family
    cl27863
    Location:304441
    SSL_OB; Staphylococcal superantigen-like OB-fold domain
  2. XM_024448717.1XP_024304485.1  proteoglycan 4 isoform X2

    Conserved Domains (4) summary
    smart00201
    Location:2567
    SO; Somatomedin B -like domains
    cd00094
    Location:11021362
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cl26247
    Location:258378
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl26464
    Location:333798
    Atrophin-1; Atrophin-1 family
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