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CDK6 cyclin dependent kinase 6 [ Homo sapiens (human) ]

Gene ID: 1021, updated on 12-Apr-2026
Official Symbol
CDK6provided by HGNC
Official Full Name
cyclin dependent kinase 6provided by HGNC
Primary source
HGNC:HGNC:1777
See related
Ensembl:ENSG00000105810 MIM:603368; AllianceGenome:HGNC:1777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCPH12; PLSTIRE
Summary
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in placenta (RPKM 9.3), bone marrow (RPKM 7.6) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CDK6 in Genome Data Viewer
Location:
7q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (92604921..92836573, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (93846868..94078562, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (92234235..92465887, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26264 Neighboring gene uncharacterized LOC105375397 Neighboring gene family with sequence similarity 133 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18373 Neighboring gene Sharpr-MPRA regulatory region 6214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26266 Neighboring gene uncharacterized LOC112268009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26268 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:92324714-92325913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26270 Neighboring gene NANOG hESC enhancer GRCh37_chr7:92353193-92353749 Neighboring gene RNA, U6 small nuclear 10, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26272 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:92393426-92394053 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:92397855-92398394 Neighboring gene MPRA-validated peak6637 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26273 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:92438696-92439895 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:92462135-92462635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18376 Neighboring gene CDK6 antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3172 Neighboring gene RNA, 7SL, cytoplasmic 7, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:92651586-92652785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92657799-92658383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92668331-92668846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92669879-92670393 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:92673175-92673906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:92737283-92738482 Neighboring gene sterile alpha motif domain containing 9

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
    Title: Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
  2. Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
    Title: Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
  3. CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
    Title: CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
  4. Deregulation of the p19/CDK4/CDK6 axis in Jak2[V617F] megakaryocytes accelerates the development of myelofibrosis.
    Title: Deregulation of the p19/CDK4/CDK6 axis in Jak2(V617F) megakaryocytes accelerates the development of myelofibrosis.
  5. Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
    Title: Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
  6. DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway.
    Title: DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway.
  7. CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma.
    Title: CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma.
  8. Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis.
    Title: Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis.
  9. FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy.
    Title: FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy.
  10. METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
    Title: METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
Submit: New GeneRIF Correction See all GeneRIFs (284)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephaly 12, primary, autosomal recessive
MedGen: C4015156 OMIM: 616080 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association analysis identifies 20 loci that influence adult height.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog
Identification of ten loci associated with height highlights new biological pathways in human growth.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CDK6 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of cyclin-dependent kinase 6 (CDK6) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC59692

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables FBXO family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in astrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell dedifferentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell dedifferentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dentate gyrus development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in generation of neurons ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
involved_in lateral ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in type B pancreatic cell development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin D2-CDK6 complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cyclin-dependent kinase 6
Names
cell division protein kinase 6
serine/threonine-protein kinase PLSTIRE
NP_001138778.1
NP_001250.1
XP_047275672.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015888.1 RefSeqGene

    Range
    5001..236707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_991

mRNA and Protein(s)

  1. NM_001145306.2 → NP_001138778.1  cyclin-dependent kinase 6

    See identical proteins and their annotated locations for NP_001138778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript.
    Source sequence(s)
    AC000065, AC005156, AK313491, AW665776, BC027989, BC052264, BQ773638
    Consensus CDS
    CCDS5628.1
    UniProtKB/Swiss-Prot
    A4D1G0, Q00534
    Related
    ENSP00000397087.3, ENST00000424848.3
    Conserved Domains (1) summary
    cd07862
    Location:11 → 300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

  2. NM_001259.8 → NP_001250.1  cyclin-dependent kinase 6

    See identical proteins and their annotated locations for NP_001250.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2.
    Source sequence(s)
    AC000065, AC004011, AC005156, AI738486, BC027989, BC052264, BQ773638
    Consensus CDS
    CCDS5628.1
    UniProtKB/Swiss-Prot
    A4D1G0, Q00534
    Related
    ENSP00000265734.4, ENST00000265734.8
    Conserved Domains (1) summary
    cd07862
    Location:11 → 300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    92604921..92836573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419716.1 → XP_047275672.1  cyclin-dependent kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    A4D1G0, Q00534
    Related
    ENSP00000576340.1, ENST00000906281.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    93846868..94078562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00534.1 GenPept UniProtKB/Swiss-Prot:Q00534

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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Tools
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