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CALCRL calcitonin receptor like receptor [ Homo sapiens (human) ]

Gene ID: 10203, updated on 7-Dec-2018

Summary

Official Symbol
CALCRLprovided by HGNC
Official Full Name
calcitonin receptor like receptorprovided by HGNC
Primary source
HGNC:HGNC:16709
See related
Ensembl:ENSG00000064989 MIM:114190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRLR; CGRPR
Expression
Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues See more
Orthologs

Genomic context

See CALCRL in Genome Data Viewer
Location:
2q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (187341963..187448304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (188206690..188313021, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 42 Neighboring gene uncharacterized LOC105373786 Neighboring gene RNA, U6 small nuclear 989, pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 59 Neighboring gene tissue factor pathway inhibitor Neighboring gene uncharacterized LOC105373788

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
    Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
    Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
adrenomedullin binding IPI
Inferred from Physical Interaction
more info
PubMed 
adrenomedullin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenomedullin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
calcitonin gene-related peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitonin gene-related peptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
adrenomedullin receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin gene-related peptide receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to sucrose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein transport IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
CGRP receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
adrenomedullin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
calcitonin gene-related peptide type 1 receptor
Names
CGRP type 1 receptor
calcitonin receptor-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271751.1NP_001258680.1  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_001258680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007319, AC074020, AK292998, DA217003
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q16602
    Related
    ENSP00000387190.1, ENST00000410068.5
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138401
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_005795.6NP_005786.1  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_005786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007319, AC074020, DA217003, U17473
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q16602
    Related
    ENSP00000376177.3, ENST00000392370.7
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138401
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    187341963..187448304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246234.4XP_005246291.2  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246291.2

    UniProtKB/TrEMBL
    D3DPG9
    Conserved Domains (2) summary
    pfam00002
    Location:149391
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:73141
    HRM; Hormone receptor domain
  2. XM_017003151.2XP_016858640.1  calcitonin gene-related peptide type 1 receptor isoform X1

    UniProtKB/TrEMBL
    D3DPG9
    Conserved Domains (2) summary
    pfam00002
    Location:149391
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:73141
    HRM; Hormone receptor domain
  3. XM_005246231.3XP_005246288.2  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246288.2

    UniProtKB/TrEMBL
    D3DPG9
    Related
    ENSP00000386972.1, ENST00000409998.5
    Conserved Domains (2) summary
    pfam00002
    Location:149391
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:73141
    HRM; Hormone receptor domain
  4. XM_005246232.3XP_005246289.2  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246289.2

    UniProtKB/TrEMBL
    D3DPG9
    Conserved Domains (2) summary
    pfam00002
    Location:149391
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:73141
    HRM; Hormone receptor domain
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