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CALCRL calcitonin receptor like receptor [ Homo sapiens (human) ]

Gene ID: 10203, updated on 26-Oct-2022

Summary

Official Symbol
CALCRLprovided by HGNC
Official Full Name
calcitonin receptor like receptorprovided by HGNC
Primary source
HGNC:HGNC:16709
See related
Ensembl:ENSG00000064989 MIM:114190; AllianceGenome:HGNC:16709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRLR; CGRPR; LMPHM8
Summary
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See CALCRL in Genome Data Viewer
Location:
2q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (187341964..187448252, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (187831183..187937204, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (188206691..188312979, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CALCRL and TFPI antisense RNA 1 Neighboring gene RNA, U6 small nuclear 989, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15572 Neighboring gene Sharpr-MPRA regulatory region 13492 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 59 Neighboring gene Sharpr-MPRA regulatory region 10664 Neighboring gene tissue factor pathway inhibitor Neighboring gene uncharacterized LOC105373788

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables adrenomedullin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables adrenomedullin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adrenomedullin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcitonin gene-related peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcitonin gene-related peptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adrenomedullin receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcitonin gene-related peptide receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to sucrose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CGRP receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of adrenomedullin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
calcitonin gene-related peptide type 1 receptor
Names
CGRP type 1 receptor
calcitonin receptor-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271751.2NP_001258680.1  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_001258680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007319, AC074020, AK292998
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q16602, Q53TS5
    Related
    ENSP00000387190.1, ENST00000410068.5
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138411
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_001369434.1NP_001356363.1  calcitonin gene-related peptide type 1 receptor precursor

    Status: VALIDATED

    Source sequence(s)
    AC007319, AC074020, KF456755
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q53TS5
    Related
    ENSP00000386972.1, ENST00000409998.5
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138411
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  3. NM_001369435.1NP_001356364.1  calcitonin gene-related peptide type 1 receptor precursor

    Status: VALIDATED

    Source sequence(s)
    AC007319, AC074020, KF456755
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q53TS5
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138411
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  4. NM_005795.6NP_005786.1  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_005786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007319, AC074020, DA217003, U17473
    Consensus CDS
    CCDS2293.1
    UniProtKB/Swiss-Prot
    Q16602, Q53TS5
    Related
    ENSP00000376177.3, ENST00000392370.8
    Conserved Domains (2) summary
    pfam02793
    Location:62130
    HRM; Hormone receptor domain
    cd15274
    Location:138411
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    187341964..187448252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442888.1XP_047298844.1  calcitonin gene-related peptide type 1 receptor isoform X1

    UniProtKB/TrEMBL
    D3DPG9
  2. XM_005246232.4XP_005246289.2  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246289.2

    UniProtKB/TrEMBL
    D3DPG9
    Conserved Domains (2) summary
    cd15274
    Location:149422
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:73141
    HRM; Hormone receptor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    187831183..187937204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)