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NME6 NME/NM23 nucleoside diphosphate kinase 6 [ Homo sapiens (human) ]

Gene ID: 10201, updated on 1-Jun-2020

Summary

Official Symbol
NME6provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 6provided by HGNC
Primary source
HGNC:HGNC:20567
See related
Ensembl:ENSG00000172113 MIM:608294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDK 6; NM23-H6; IPIA-ALPHA
Summary
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See NME6 in Genome Data Viewer
Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48288402..48302904, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48335485..48343719, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9849 Neighboring gene zinc finger protein 589 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene FCF1 pseudogene 2 Neighboring gene serine peptidase inhibitor Kazal type 8 (putative) Neighboring gene microRNA 2115 Neighboring gene F-box and WD repeat domain containing 12 Neighboring gene RNA, 7SL, cytoplasmic 321, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies NME6, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleoside diphosphate kinase 6
Names
NDP kinase 6
inhibitor of p53-induced apoptosis-alpha
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
NP_001295355.1
NP_001295356.1
NP_001295357.1
NP_001295359.1
NP_001295360.1
NP_001295362.1
NP_001295363.1
NP_001295364.1
NP_005784.1
XP_016861000.1
XP_016861001.1
XP_016861002.1
XP_016861003.1
XP_016861004.1
XP_016861005.1
XP_016861006.1
XP_016861007.1
XP_024309065.1
XP_024309066.1
XP_024309067.1
XP_024309068.1
XP_024309069.1
XP_024309070.1
XP_024309071.1
XP_024309072.1
XP_024309073.1
XP_024309074.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308426.1NP_001295355.1  nucleoside diphosphate kinase 6 isoform 2

    See identical proteins and their annotated locations for NP_001295355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105267, AK222555, AK309090, BQ020663, CT002144
    Consensus CDS
    CCDS77734.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000406642.1, ENST00000442597.5
    Conserved Domains (1) summary
    cd04414
    Location:12146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  2. NM_001308427.1NP_001295356.1  nucleoside diphosphate kinase 6 isoform 2

    See identical proteins and their annotated locations for NP_001295356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105267, BE866839, BQ020663
    Consensus CDS
    CCDS77734.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000411116.1, ENST00000425930.5
    Conserved Domains (1) summary
    cd04414
    Location:12146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  3. NM_001308428.1NP_001295357.1  nucleoside diphosphate kinase 6 isoform 2

    See identical proteins and their annotated locations for NP_001295357.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105267, BQ020663, DA398008
    Consensus CDS
    CCDS77734.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000495130.1, ENST00000643457.1
    Conserved Domains (1) summary
    cd04414
    Location:12146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  4. NM_001308430.1NP_001295359.1  nucleoside diphosphate kinase 6 isoform 3

    See identical proteins and their annotated locations for NP_001295359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC105267, BG284082, BQ020663
    Conserved Domains (1) summary
    cl00335
    Location:2072
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  5. NM_001308431.1NP_001295360.1  nucleoside diphosphate kinase 6 isoform 4

    See identical proteins and their annotated locations for NP_001295360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, and the 3' coding region contains a frameshift which results in an early stop codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4)
    Source sequence(s)
    AC105267, BQ020663, CT002144
    Consensus CDS
    CCDS77733.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000407933.1, ENST00000451657.6
    Conserved Domains (1) summary
    cl00335
    Location:1264
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  6. NM_001308433.1NP_001295362.1  nucleoside diphosphate kinase 6 isoform 4

    See identical proteins and their annotated locations for NP_001295362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences, compared to variant 1. These differences result in translation initiation at a downstream start codon, and the 3' coding region contains a frameshift which results in an early stop codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4)
    Source sequence(s)
    AC105267, AK294809, BQ020663
    Consensus CDS
    CCDS77733.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000393261.1, ENST00000435684.5
    Conserved Domains (1) summary
    cl00335
    Location:1264
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  7. NM_001308434.1NP_001295363.1  nucleoside diphosphate kinase 6 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains a distinct 5' UTR, uses an alternate splice site in the 5' terminal exon, lacks an alternate 5' exon, and initiates translation at a downstream AUG, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC105267, BG530435, BQ020663
    Consensus CDS
    CCDS82767.1
    UniProtKB/TrEMBL
    C9JQB1
    Related
    ENSP00000414842.1, ENST00000447314.5
    Conserved Domains (1) summary
    cl00335
    Location:1101
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  8. NM_001308435.1NP_001295364.1  nucleoside diphosphate kinase 6 isoform 6

    See identical proteins and their annotated locations for NP_001295364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains a distinct 5' UTR, uses an alternate splice site in the 5' terminal exon, initiates translation at a downstream AUG, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC105267, AK297364, BQ020663
    Consensus CDS
    CCDS82768.1
    UniProtKB/Swiss-Prot
    O75414
    Related
    ENSP00000394232.1, ENST00000415644.5
    Conserved Domains (1) summary
    cl00335
    Location:1264
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  9. NM_005793.4NP_005784.1  nucleoside diphosphate kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_005784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC105267, AL699803, BC001808, BQ020663, CA848473, CD701581, CN287719, DA519225, DA737691, DA912668, DB114903, HY090220
    Consensus CDS
    CCDS2763.1
    UniProtKB/Swiss-Prot
    O75414
    UniProtKB/TrEMBL
    A0A0C4DG91
    Related
    ENSP00000416658.1, ENST00000421967.5
    Conserved Domains (1) summary
    cd04414
    Location:20154
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48288402..48302904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453298.1XP_024309066.1  nucleoside diphosphate kinase 6 isoform X2

    Conserved Domains (2) summary
    cl00335
    Location:155209
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    cl26386
    Location:24132
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_024453299.1XP_024309067.1  nucleoside diphosphate kinase 6 isoform X3

    Conserved Domains (1) summary
    cd04414
    Location:56175
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  3. XM_024453302.1XP_024309070.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  4. XM_024453301.1XP_024309069.1  nucleoside diphosphate kinase 6 isoform X7

    Conserved Domains (1) summary
    cd04414
    Location:16135
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  5. XM_024453304.1XP_024309072.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  6. XM_024453303.1XP_024309071.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  7. XM_024453305.1XP_024309073.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  8. XM_017005511.2XP_016861000.1  nucleoside diphosphate kinase 6 isoform X4

  9. XM_024453297.1XP_024309065.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  10. XM_024453306.1XP_024309074.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (1) summary
    cd04414
    Location:12131
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  11. XM_017005516.2XP_016861005.1  nucleoside diphosphate kinase 6 isoform X11

  12. XM_024453300.1XP_024309068.1  nucleoside diphosphate kinase 6 isoform X5

    Conserved Domains (1) summary
    cd04414
    Location:20139
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  13. XM_017005512.2XP_016861001.1  nucleoside diphosphate kinase 6 isoform X6

  14. XM_017005515.1XP_016861004.1  nucleoside diphosphate kinase 6 isoform X10

    UniProtKB/Swiss-Prot
    O75414
    Conserved Domains (1) summary
    cl00335
    Location:1264
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  15. XM_017005514.2XP_016861003.1  nucleoside diphosphate kinase 6 isoform X9

    UniProtKB/Swiss-Prot
    O75414
    Conserved Domains (1) summary
    cd04414
    Location:12146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  16. XM_017005517.1XP_016861006.1  nucleoside diphosphate kinase 6 isoform X12

    Related
    ENSP00000496560.1, ENST00000643011.1
  17. XM_017005513.2XP_016861002.1  nucleoside diphosphate kinase 6 isoform X8

    Conserved Domains (2) summary
    smart00562
    Location:16153
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:16150
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
  18. XM_017005518.2XP_016861007.1  nucleoside diphosphate kinase 6 isoform X13

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