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MPHOSPH6 M-phase phosphoprotein 6 [ Homo sapiens (human) ]

Gene ID: 10200, updated on 8-Jul-2018
Official Symbol
MPHOSPH6provided by HGNC
Official Full Name
M-phase phosphoprotein 6provided by HGNC
Primary source
HGNC:HGNC:7214
See related
Ensembl:ENSG00000135698 MIM:605500; Vega:OTTHUMG00000137632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPP; MPP6; MPP-6
Expression
Ubiquitous expression in appendix (RPKM 8.9), urinary bladder (RPKM 8.6) and 24 other tissues See more
Orthologs
See MPHOSPH6 in Genome Data Viewer
Location:
16q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (82148162..82170224, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (82181767..82203829, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MT-CYB pseudogene 28 Neighboring gene MT-ND6 pseudogene 28 Neighboring gene RNA, 7SK small nuclear pseudogene 190 Neighboring gene ribosomal protein L21 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of M-phase phosphoprotein 6 (MPHOSPH6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nuclear exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005792.2NP_005783.2  M-phase phosphoprotein 6

    See identical proteins and their annotated locations for NP_005783.2

    Status: VALIDATED

    Source sequence(s)
    AI831131, AW175781, BU595100, BU622913
    Consensus CDS
    CCDS10937.1
    UniProtKB/Swiss-Prot
    Q99547
    Related
    ENSP00000258169.4, OTTHUMP00000174980, ENST00000258169.8, OTTHUMT00000269058
    Conserved Domains (1) summary
    pfam10175
    Location:8135
    MPP6; M-phase phosphoprotein 6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    82148162..82170224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522808.3XP_011521110.1  M-phase phosphoprotein 6 isoform X1

    UniProtKB/TrEMBL
    H3BNT4
    Related
    ENSP00000454996.1, OTTHUMP00000254518, ENST00000563100.5
    Conserved Domains (1) summary
    pfam10175
    Location:1117
    MPP6; M-phase phosphoprotein 6
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