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TXNDC9 thioredoxin domain containing 9 [ Homo sapiens (human) ]

Gene ID: 10190, updated on 21-Dec-2019

Summary

Official Symbol
TXNDC9provided by HGNC
Official Full Name
thioredoxin domain containing 9provided by HGNC
Primary source
HGNC:HGNC:24110
See related
Ensembl:ENSG00000115514 MIM:612564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APACD; PHLP3
Summary
The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See TXNDC9 in Genome Data Viewer
Location:
2q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (99306184..99336385, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99935487..99957155, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985923 Neighboring gene lysozyme g2 Neighboring gene lysozyme g1 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene REV1 DNA directed polymerase Neighboring gene AF4/FMR2 family member 3 Neighboring gene uncharacterized LOC105373504

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin domain-containing protein 9
Names
ATP binding protein associated with cell differentiation
protein 1-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005783.4NP_005774.2  thioredoxin domain-containing protein 9

    See identical proteins and their annotated locations for NP_005774.2

    Status: REVIEWED

    Source sequence(s)
    AC079447, BC070183, BG772935
    Consensus CDS
    CCDS2044.1
    UniProtKB/Swiss-Prot
    O14530
    Related
    ENSP00000264255.3, ENST00000264255.8
    Conserved Domains (1) summary
    cd02989
    Location:68180
    Phd_like_TxnDC9; Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily; composed of predominantly uncharacterized eukaryotic proteins, containing a TRX-like domain without the redox active CXXC motif. The gene name for the human ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    99306184..99336385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003147.2XP_016858636.1  thioredoxin domain-containing protein 9 isoform X1

    Related
    ENSP00000387275.1, ENST00000409434.5
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