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Smg5 SMG5 nonsense mediated mRNA decay factor [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101709860, updated on 8-Mar-2024

Summary

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Gene symbol
Smg5
Gene description
SMG5 nonsense mediated mRNA decay factor
See related
Ensembl:ENSHGLG00000019152
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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See Smg5 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624885.1 (1532101..1565811, complement)

NW_004624885.1Genomic Context describing neighboring genes Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene transmembrane protein 79 Neighboring gene glycosylated lysosomal membrane protein Neighboring gene chaperonin containing TCP1 subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624885 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of telomerase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein SMG5
Names
smg-5 homolog, nonsense mediated mRNA decay factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624885.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    1532101..1565811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021249530.1 → XP_021105189.1  protein SMG5 isoform X3

    UniProtKB/TrEMBL
    G5AR95
    Conserved Domains (3) summary
    cd09884
    Location:791 → 949
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:131 → 330
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:11 → 121
    EST1; Telomerase activating protein Est1

  2. XM_021249529.1 → XP_021105188.1  protein SMG5 isoform X2

    UniProtKB/TrEMBL
    G5AR95
    Conserved Domains (3) summary
    cd09884
    Location:824 → 982
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:164 → 363
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:44 → 154
    EST1; Telomerase activating protein Est1

  3. XM_004871198.3 → XP_004871255.1  protein SMG5 isoform X1

    UniProtKB/TrEMBL
    A0A0P6JD71, G5AR95
    Related
    ENSHGLP00000026928.1, ENSHGLT00000027167.1
    Conserved Domains (3) summary
    cd09884
    Location:857 → 1015
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:197 → 412
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:77 → 187
    EST1; Telomerase activating protein Est1
Nucleotide Protein
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