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Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 229512, updated on 26-Nov-2016
Official Symbol
Smg5provided by MGI
Official Full Name
Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)provided by MGI
Primary source
MGI:MGI:2447364
See related
Ensembl:ENSMUSG00000001415 Vega:OTTMUSG00000052142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BC024683; mKIAA1089
Orthologs
Location:
3; 3 F1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (88336260..88362337)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88140182..88166259)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene transmembrane protein 79 Neighboring gene progestin and adipoQ receptor family member VI Neighboring gene bone gamma-carboxyglutamate protein 3

Markers

Homology

Clone Names

  • MGC30464, MGC56792, MGC118167

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of RNA stability IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
telomerase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
protein SMG5
Names
EST1-like protein B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178246.3NP_839977.2  protein SMG5

    See identical proteins and their annotated locations for NP_839977.2

    Status: VALIDATED

    Source sequence(s)
    AK133688, AK143911, AV146226, BB869373, BC066787
    Consensus CDS
    CCDS38480.1
    UniProtKB/Swiss-Prot
    Q6ZPY2
    UniProtKB/TrEMBL
    Q3UZS1
    Related
    ENSMUSP00000001451, OTTMUSP00000070126, ENSMUST00000001451, OTTMUST00000131031
    Conserved Domains (4) summary
    sd00006
    Location:172206
    TPR; TPR repeat [structural motif]
    pfam10373
    Location:197411
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:77187
    EST1; Telomerase activating protein Est1
    cl14812
    Location:8561014
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    88336260..88362337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501346.3XP_006501409.1  

    Conserved Domains (3) summary
    sd00006
    Location:172206
    TPR; TPR repeat [structural motif]
    pfam10373
    Location:197411
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:77187
    EST1; Telomerase activating protein Est1
  2. XM_006501343.3XP_006501406.1  

    Conserved Domains (4) summary
    sd00006
    Location:158192
    TPR; TPR repeat [structural motif]
    pfam10373
    Location:183397
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:77173
    EST1; Telomerase activating protein Est1
    cl14812
    Location:8421000
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  3. XM_011240087.2XP_011238389.1  

    Conserved Domains (4) summary
    sd00006
    Location:106140
    TPR; TPR repeat [structural motif]
    pfam10373
    Location:131345
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:11121
    EST1; Telomerase activating protein Est1
    cl14812
    Location:790948
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  4. XM_006501345.2XP_006501408.1  

    Conserved Domains (2) summary
    pfam10373
    Location:1150
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    cl14812
    Location:595753
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173188.1: Suppressed sequence

    Description
    NM_173188.1: This RefSeq was temporarily suppressed because the CDS was partial when compared to proteins in other species such as human.
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