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Casp9 caspase 9 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101702898, updated on 8-Mar-2024

Summary

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Gene symbol
Casp9
Gene description
caspase 9
See related
Ensembl:ENSHGLG00000019310
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624764.1 (1769270..1789399, complement)

NW_004624764.1Genomic Context describing neighboring genes Neighboring gene chymotrypsin C Neighboring gene chymotrypsin-like elastase family member 2A Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene protein FAM92A pseudogene Neighboring gene agmatinase (putative)

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624764 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-9

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624764.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    1769270..1789399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021262840.1 → XP_021118499.1  caspase-9 isoform X2

    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 386
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_021262841.1 → XP_021118500.1  caspase-9 isoform X3

    UniProtKB/TrEMBL
    G5BRS8
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 425
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  3. XM_021262842.1 → XP_021118501.1  caspase-9 isoform X5

    UniProtKB/TrEMBL
    G5BRS8
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 387
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  4. XM_021262839.1 → XP_021118498.1  caspase-9 isoform X1

    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 386
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  5. XM_004850324.3 → XP_004850381.1  caspase-9 isoform X4

    UniProtKB/TrEMBL
    A0A0N8ESW5, G5BRS8
    Related
    ENSHGLP00000027149.1, ENSHGLT00000027390.1
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 450
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  6. XM_021262844.1 → XP_021118503.1  caspase-9 isoform X6

    Conserved Domains (1) summary
    cd00032
    Location:79 → 276
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  7. XM_013074268.2 → XP_012929722.1  caspase-9 isoform X7

    UniProtKB/TrEMBL
    G5BRS8
    Conserved Domains (2) summary
    cd08326
    Location:5 → 90
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:189 → 387
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
Nucleotide Protein
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