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CHST4 carbohydrate sulfotransferase 4 [ Homo sapiens (human) ]

Gene ID: 10164, updated on 12-Oct-2019

Summary

Official Symbol
CHST4provided by HGNC
Official Full Name
carbohydrate sulfotransferase 4provided by HGNC
Primary source
HGNC:HGNC:1972
See related
Ensembl:ENSG00000140835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
Summary
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward gall bladder (RPKM 42.6) See more
Orthologs

Genomic context

See CHST4 in Genome Data Viewer
Location:
16q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (71526120..71538748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71560023..71572493)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 19 Neighboring gene uncharacterized LOC105371335 Neighboring gene RNA, U6 small nuclear 1061, pseudogene Neighboring gene TAT antisense RNA 1 Neighboring gene tyrosine aminotransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylglucosamine 6-O-sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
O-glycan processing TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sulfation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 4
Names
GST-3
HEC-GlcNAc6ST
L-selectin ligand sulfotransferase
N-acetylglucosamine 6-O-sulfotransferase 2
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
glcNAc6ST-2
gn6st-2
high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
NP_001159867.1
NP_005760.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029801.1 RefSeqGene

    Range
    5001..17471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166395.2NP_001159867.1  carbohydrate sulfotransferase 4

    See identical proteins and their annotated locations for NP_001159867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010547, BC035282, DA045171
    Consensus CDS
    CCDS10902.1
    UniProtKB/Swiss-Prot
    Q8NCG5
    Related
    ENSP00000441204.3, ENST00000539698.3
    Conserved Domains (1) summary
    cl21551
    Location:168358
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_005769.2NP_005760.1  carbohydrate sulfotransferase 4

    See identical proteins and their annotated locations for NP_005760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC010547, AF131235, BC035282, DA496702
    Consensus CDS
    CCDS10902.1
    UniProtKB/Swiss-Prot
    Q8NCG5
    Related
    ENSP00000341206.5, ENST00000338482.5
    Conserved Domains (1) summary
    cl21551
    Location:168358
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    71526120..71538748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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