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RASA4 RAS p21 protein activator 4 [ Homo sapiens (human) ]

Gene ID: 10156, updated on 5-Jan-2020

Summary

Official Symbol
RASA4provided by HGNC
Official Full Name
RAS p21 protein activator 4provided by HGNC
Primary source
HGNC:HGNC:23181
See related
Ensembl:ENSG00000105808 MIM:607943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAPL; CAPRI
Summary
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 14.7), spleen (RPKM 11.8) and 24 other tissues See more
Orthologs

Genomic context

See RASA4 in Genome Data Viewer
Location:
7q22.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102579646..102616758, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102220093..102257205, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uroplakin 3B like 2 Neighboring gene RNA polymerase II subunit J3 Neighboring gene speedy/RINGO cell cycle regulator family member E2 Neighboring gene RNA polymerase II subunit J2 Neighboring gene uroplakin 3B like 1 Neighboring gene speedy/RINGO cell cycle regulator family member E2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ59070, KIAA0538, MGC131890

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras GTPase-activating protein 4
Names
Ca2+-promoted Ras inactivator
calcium-promoted Ras inactivator
rasGAP-activating-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079877.2NP_001073346.2  ras GTPase-activating protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC093668, AC105052
    Consensus CDS
    CCDS47674.1
    UniProtKB/Swiss-Prot
    O43374
    Related
    ENSP00000412876.2, ENST00000449970.6
    Conserved Domains (5) summary
    cd04025
    Location:134257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cl17171
    Location:542635
    PH-like; Pleckstrin homology-like domain
  2. NM_006989.6NP_008920.5  ras GTPase-activating protein 4 isoform 1

    See identical proteins and their annotated locations for NP_008920.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093668, AC105052
    Consensus CDS
    CCDS5725.1
    UniProtKB/Swiss-Prot
    O43374
    Related
    ENSP00000262940.7, ENST00000262940.11
    Conserved Domains (7) summary
    cd04025
    Location:134257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13372
    Location:542681
    PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
    pfam00169
    Location:567672
    PH; PH domain
    pfam00779
    Location:681709
    BTK; BTK motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102579646..102616758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011662.2XP_016867151.1  ras GTPase-activating protein 4 isoform X2

  2. XM_017011661.2XP_016867150.1  ras GTPase-activating protein 4 isoform X1

  3. XM_011515723.1XP_011514025.1  ras GTPase-activating protein 4 isoform X3

    Conserved Domains (5) summary
    cd04025
    Location:134257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cl17171
    Location:542611
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_001744511.2 RNA Sequence

  2. XR_428164.3 RNA Sequence

  3. XR_002956404.1 RNA Sequence

  4. XR_001744512.2 RNA Sequence

  5. XR_001744509.2 RNA Sequence

  6. XR_001744508.2 RNA Sequence

  7. XR_001744510.2 RNA Sequence

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