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Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Mus musculus (house mouse) ]

Gene ID: 101502, updated on 8-Feb-2024

Summary

Official Symbol
Hsd3b7provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by MGI
Primary source
MGI:MGI:2141879
See related
Ensembl:ENSMUSG00000042289 AllianceGenome:MGI:2141879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity. Involved in B cell chemotaxis. Predicted to be located in intracellular membrane-bounded organelle and lipid droplet. Is expressed in several structures, including alimentary system; bladder; facial bone primordium; heart; and liver and biliary system. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1 and intrahepatic cholestasis. Orthologous to human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 369.2), liver E18 (RPKM 105.2) and 11 other tissues See more
Orthologs
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Genomic context

See Hsd3b7 in Genome Data Viewer
Location:
7 F3; 7 69.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127399830..127402973)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127800609..127803802)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134920056-134920165 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134920423-134920532 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A Neighboring gene syntaxin 1B Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in B cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3 beta-hydroxysteroid dehydrogenase type 7
Names
3 beta-hydroxysteroid dehydrogenase type VII
3-beta-HSD VII
3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
c(27) 3-beta-HSD
cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
NP_001035774.1
NP_001407168.1
NP_001407169.1
NP_001407170.1
NP_001407171.1
NP_001407172.1
NP_001407173.1
NP_598704.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040684.2NP_001035774.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Conserved Domains (2) summary
    pfam01073
    Location:2256
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:1334
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001420239.1NP_001407168.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC149222
  3. NM_001420240.1NP_001407169.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/TrEMBL
    D3Z3X1
  4. NM_001420241.1NP_001407170.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC149222
  5. NM_001420242.1NP_001407171.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC149222
  6. NM_001420243.1NP_001407172.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC149222
  7. NM_001420244.1NP_001407173.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC149222
  8. NM_133943.3NP_598704.2  3 beta-hydroxysteroid dehydrogenase type 7 isoform a

    See identical proteins and their annotated locations for NP_598704.2

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS40145.1
    UniProtKB/Swiss-Prot
    A2RTR5, Q9EQC1
    Related
    ENSMUSP00000036245.6, ENSMUST00000046863.12
    Conserved Domains (2) summary
    cd09811
    Location:11361
    3b-HSD_HSDB1_like_SDR_e; human 3beta-HSD (hydroxysteroid dehydrogenase) and HSD3B1(delta 5-delta 4-isomerase)-like, extended (e) SDRs
    pfam01073
    Location:13283
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

RNA

  1. NR_185150.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149222
  2. NR_185151.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149222
  3. NR_185152.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149222
  4. NR_185153.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149222
  5. NR_185154.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149222

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127399830..127402973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)