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AKAP9 A-kinase anchoring protein 9 [ Homo sapiens (human) ]

Gene ID: 10142, updated on 8-Jul-2021

Summary

Official Symbol
AKAP9provided by HGNC
Official Full Name
A-kinase anchoring protein 9provided by HGNC
Primary source
HGNC:HGNC:379
See related
Ensembl:ENSG00000127914 MIM:604001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in colon (RPKM 12.3), small intestine (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See AKAP9 in Genome Data Viewer
Location:
7q21.2
Exon count:
51
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (91940862..92110673)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91570176..91739987)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375392 Neighboring gene uncharacterized LOC101927473 Neighboring gene uncharacterized LOC112267986 Neighboring gene mitochondrial transcription termination factor 1 Neighboring gene Sharpr-MPRA regulatory region 2641 Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene leucine rich repeats and death domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
GeneReviews: Not available
Long QT syndrome 11
MedGen: C2678483 OMIM: 611820 GeneReviews: Long QT Syndrome
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with A kinase (PRKA) anchor protein 9 (AKAP9) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular protein-containing complex localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in maintenance of centrosome location IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of centrosome location IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of potassium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Golgi organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic branch IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 9
Names
A kinase (PRKA) anchor protein (yotiao) 9
A kinase (PRKA) anchor protein 9
A-kinase anchor protein 350 kDa
A-kinase anchor protein 450 kDa
AKAP 120-like protein
AKAP9-BRAF fusion protein
centrosome- and Golgi-localized PKN-associated protein
centrosome- and golgi-localized protein kinase N-associated protein
kinase N-associated protein
protein hyperion
protein kinase A anchoring protein 9
protein phosphatase 1, regulatory subunit 45
protein yotiao

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011623.1 RefSeqGene

    Range
    5001..174799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_331

mRNA and Protein(s)

  1. NM_001379277.1NP_001366206.1  A-kinase anchor protein 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC000120, AC004013
    Related
    ENSP00000494626.2, ENST00000491695.2
    Conserved Domains (4) summary
    COG1196
    Location:231584
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:347968
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17380
    Location:62372
    DUF5401; Family of unknown function (DUF5401)
    pfam10495
    Location:19192000
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
  2. NM_005751.5NP_005742.4  A-kinase anchor protein 9 isoform 2

    See identical proteins and their annotated locations for NP_005742.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC000066, AC000120, AC003086, AC004013
    Consensus CDS
    CCDS5622.1
    UniProtKB/Swiss-Prot
    Q99996
    UniProtKB/TrEMBL
    Q5GIA7, Q6PJH3
    Related
    ENSP00000348573.3, ENST00000356239.8
    Conserved Domains (2) summary
    pfam10495
    Location:37043785
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    cl25732
    Location:277989
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_147185.3NP_671714.1  A-kinase anchor protein 9 isoform 3

    See identical proteins and their annotated locations for NP_671714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at the end of an exon compared to variant 2. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 2.
    Source sequence(s)
    AC003086, AF083037, AJ131693, AY528715, BC015533, CR997756
    UniProtKB/Swiss-Prot
    Q99996
    UniProtKB/TrEMBL
    Q5GIA7, Q6PJH3
    Related
    ENSP00000505204.1, ENST00000680766.1
    Conserved Domains (5) summary
    COG1196
    Location:277989
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02463
    Location:21922866
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam10495
    Location:36963777
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    cl19219
    Location:21102217
    DUF342; Protein of unknown function (DUF342)
    cl19548
    Location:324612
    DUF515; Protein of unknown function (DUF515)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    91940862..92110673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_147166.1: Suppressed sequence

    Description
    NM_147166.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_147171.1: Suppressed sequence

    Description
    NM_147171.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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