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STAT3 signal transducer and activator of transcription 3 [ Felis catus (domestic cat) ]

Gene ID: 101095698, updated on 17-Aug-2024

Summary

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Official Symbol
STAT3
Official Full Name
signal transducer and activator of transcription 3
Primary source
VGNC:VGNC:65761
See related
EnsemblRapid:ENSFCTG00005020635
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: E1
Exon count:
25
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E1 NC_058381.1 (40956085..41025986, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E1 NC_018736.3 (42936094..43005502, complement)

Chromosome E1 - NC_058381.1Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene uncharacterized LOC123381928 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111557793 Neighboring gene caveolae associated protein 1 Neighboring gene ATPase H+ transporting V0 subunit a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma. Brown ME, et al. BMC Vet Res, 2015 Aug 14. PMID 26272737, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058381.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    40956085..41025986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006940361.5 → XP_006940423.1  signal transducer and activator of transcription 3 isoform X4

    See identical proteins and their annotated locations for XP_006940423.1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_006940359.5 → XP_006940421.1  signal transducer and activator of transcription 3 isoform X2

    See identical proteins and their annotated locations for XP_006940421.1

    Related
    ENSFCTP00005043754.1, ENSFCTT00005059554.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_006940360.5 → XP_006940422.1  signal transducer and activator of transcription 3 isoform X3

    See identical proteins and their annotated locations for XP_006940422.1

    Related
    ENSFCTP00005043537.1, ENSFCTT00005059266.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_045044633.1 → XP_044900568.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    M3VY01
    Related
    ENSFCTP00005043911.1, ENSFCTT00005059774.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_003996881.6 → XP_003996930.1  signal transducer and activator of transcription 3 isoform X1

    See identical proteins and their annotated locations for XP_003996930.1

    UniProtKB/TrEMBL
    M3VY01
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
Nucleotide Protein
Heading Accession and Version

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