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CTDSP2 CTD small phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 10106, updated on 6-Sep-2022

Summary

Official Symbol
CTDSP2provided by HGNC
Official Full Name
CTD small phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:17077
See related
Ensembl:ENSG00000175215 MIM:608711; AllianceGenome:HGNC:17077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OS4; PSR2; SCP2
Summary
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 63.4), ovary (RPKM 53.0) and 25 other tissues See more
Orthologs
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Genomic context

See CTDSP2 in Genome Data Viewer
Location:
12q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57819927..57846729, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57788296..57815097, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58213710..58240512, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene RNA, U6 small nuclear 1083, pseudogene Neighboring gene advillin Neighboring gene microRNA 26a-2 Neighboring gene uncharacterized LOC105369783 Neighboring gene uncharacterized LOC124902948 Neighboring gene uncharacterized LOC283387 Neighboring gene Sharpr-MPRA regulatory region 14680 Neighboring gene uncharacterized LOC101927608

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
NLI-interacting factor 2
conserved gene amplified in osteosarcoma
nuclear LIM interactor-interacting factor 2
protein OS-4
small C-terminal domain phosphatase 2
small CTD phosphatase 2
NP_005721.3
XP_005268613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005730.4NP_005721.3  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

    See identical proteins and their annotated locations for NP_005721.3

    Status: VALIDATED

    Source sequence(s)
    AC121759, BC018922, CN313995
    Consensus CDS
    CCDS41801.1
    UniProtKB/Swiss-Prot
    O14595, Q9UEX1
    UniProtKB/TrEMBL
    A0A024RBA6
    Related
    ENSP00000381148.2, ENST00000398073.7
    Conserved Domains (1) summary
    TIGR02251
    Location:101260
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    57819927..57846729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268556.3XP_005268613.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform X1

    See identical proteins and their annotated locations for XP_005268613.1

    UniProtKB/TrEMBL
    A0A024RB65
    Conserved Domains (1) summary
    TIGR02251
    Location:107266
    HIF-SF_euk; Dullard-like phosphatase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    57788296..57815097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)