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Ctdsp2 CTD small phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 52468, updated on 27-Nov-2024

Summary

Official Symbol
Ctdsp2provided by MGI
Official Full Name
CTD small phosphatase 2provided by MGI
Primary source
MGI:MGI:1098748
See related
Ensembl:ENSMUSG00000078429 AllianceGenome:MGI:1098748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OS4; OS-4; SCP2; D10Ertd73e
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; integumental system; and respiratory system. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 75.2), limb E14.5 (RPKM 74.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ctdsp2 in Genome Data Viewer
Location:
10 D3; 10 74.35 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126814586..126835844)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (126978717..126999975)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30539 Neighboring gene STARR-seq mESC enhancer starr_28199 Neighboring gene STARR-positive B cell enhancer ABC_E3925 Neighboring gene predicted gene, 40798 Neighboring gene microRNA 26a-2 Neighboring gene microRNA 546 Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Clone Names

  • MGC38258

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4)
small C-terminal domain phosphatase 2
NP_001106941.1
NP_666124.1
XP_036011783.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113470.1NP_001106941.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_001106941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK049271, BB731474, BC085142
    Consensus CDS
    CCDS48711.1
    UniProtKB/Swiss-Prot
    Q8BX07
    Related
    ENSMUSP00000100891.3, ENSMUST00000105256.10
    Conserved Domains (1) summary
    TIGR02251
    Location:100259
    HIF-SF_euk; Dullard-like phosphatase domain
  2. NM_146012.2NP_666124.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform b

    See identical proteins and their annotated locations for NP_666124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA103008, AK049271, BB731474, CB527995
    Consensus CDS
    CCDS36076.1
    UniProtKB/TrEMBL
    Q8R3B3
    Related
    ENSMUSP00000100890.3, ENSMUST00000105255.3
    Conserved Domains (1) summary
    cl21460
    Location:1108
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126814586..126835844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155890.1XP_036011783.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform X1

    Conserved Domains (1) summary
    TIGR02251
    Location:87246
    HIF-SF_euk; Dullard-like phosphatase domain