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NUBP2 nucleotide binding protein 2 [ Homo sapiens (human) ]

Gene ID: 10101, updated on 7-Jun-2020

Summary

Official Symbol
NUBP2provided by HGNC
Official Full Name
nucleotide binding protein 2provided by HGNC
Primary source
HGNC:HGNC:8042
See related
Ensembl:ENSG00000095906 MIM:610779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFD1; CIAO6; NBP 2; NUBP1
Summary
This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in fat (RPKM 8.3), prostate (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See NUBP2 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1782960..1789186)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1832931..1839192)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene insulin like growth factor binding protein acid labile subunit Neighboring gene hydroxyacylglutathione hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
NHGRI GWA Catalog
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle pole centrosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosolic Fe-S cluster assembly factor NUBP2
Names
homolog of yeast cytosolic Fe-S cluster deficient 1
nucleotide binding protein 2 (MinD homolog, E. coli)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284501.2NP_001271430.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    See identical proteins and their annotated locations for NP_001271430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminal compared to isoform 1.
    Source sequence(s)
    AC012180, AK300696, BC002768, BF439443, BU189242, BX446436
    Consensus CDS
    CCDS66898.1
    UniProtKB/Swiss-Prot
    Q9Y5Y2
    UniProtKB/TrEMBL
    B7Z6P0, H3BQR2
    Related
    ENSP00000455896.1, ENST00000565987.5
    Conserved Domains (1) summary
    cl21455
    Location:1202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001284502.2NP_001271431.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC012180, AK300696, BF439443, BI196883, BU189242
    UniProtKB/TrEMBL
    B7Z6P0
    Conserved Domains (2) summary
    COG0489
    Location:1258
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:1458
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_012225.4NP_036357.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 1

    See identical proteins and their annotated locations for NP_036357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK300696, BC002768, BF439443, BU189242
    Consensus CDS
    CCDS10445.1
    UniProtKB/Swiss-Prot
    Q9Y5Y2
    UniProtKB/TrEMBL
    B7Z6P0
    Related
    ENSP00000262302.9, ENST00000262302.14
    Conserved Domains (1) summary
    pfam10609
    Location:13262
    ParA; NUBPL iron-transfer P-loop NTPase

RNA

  1. NR_104318.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK300696, BF439443, BU189242
    Related
    ENST00000568834.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1782960..1789186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450135.1XP_024305903.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X2

    Conserved Domains (1) summary
    cl21455
    Location:1202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005255030.1XP_005255087.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X4

    See identical proteins and their annotated locations for XP_005255087.1

    UniProtKB/TrEMBL
    B7Z6P0
    Related
    ENSP00000460079.1, ENST00000568706.1
    Conserved Domains (2) summary
    COG0489
    Location:1291
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:14122
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_017022831.1XP_016878320.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X2

    UniProtKB/TrEMBL
    H3BQR2
    Conserved Domains (1) summary
    cl21455
    Location:1202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011522338.2XP_011520640.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

    Conserved Domains (2) summary
    COG0489
    Location:57175
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:55206
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_005255027.3XP_005255084.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X2

    See identical proteins and their annotated locations for XP_005255084.1

    UniProtKB/TrEMBL
    H3BQR2
    Conserved Domains (1) summary
    cl21455
    Location:1202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017022832.2XP_016878321.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X3

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