U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nubp2 nucleotide binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26426, updated on 21-Apr-2024

Summary

Official Symbol
Nubp2provided by MGI
Official Full Name
nucleotide binding protein 2provided by MGI
Primary source
MGI:MGI:1347072
See related
Ensembl:ENSMUSG00000039183 AllianceGenome:MGI:1347072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Wsu11e
Summary
Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to act upstream of or within cell projection organization. Located in nucleus and spindle pole centrosome. Is expressed in several structures, including extraembryonic component; genitourinary system; liver; lung; and spleen. Orthologous to human NUBP2 (nucleotide binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 44.5), thymus adult (RPKM 22.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
17 A3.3; 17 12.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25101585..25105423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24882611..24886350, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic Fe-S cluster assembly factor NUBP2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355396.1NP_001342325.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS89014.1
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1203
    ParA; NUBPL iron-transfer P-loop NTPase
  2. NM_001379052.1NP_001365981.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4L2S1
    Conserved Domains (1) summary
    pfam10609
    Location:12263
    ParA; NUBPL iron-transfer P-loop NTPase
  3. NM_001379053.1NP_001365982.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1203
    ParA; NUBPL iron-transfer P-loop NTPase
  4. NM_001379054.1NP_001365983.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1203
    ParA; NUBPL iron-transfer P-loop NTPase
  5. NM_001379055.1NP_001365984.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1203
    ParA; NUBPL iron-transfer P-loop NTPase
  6. NM_001379056.1NP_001365985.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Related
    ENSMUSP00000157378.2, ENSMUST00000234928.2
    Conserved Domains (1) summary
    pfam10609
    Location:1203
    ParA; NUBPL iron-transfer P-loop NTPase
  7. NM_011956.3NP_036086.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 1

    See identical proteins and their annotated locations for NP_036086.1

    Status: VALIDATED

    Source sequence(s)
    AF114169, BI735707, BU700400
    Consensus CDS
    CCDS28500.1
    UniProtKB/Swiss-Prot
    Q9R061
    UniProtKB/TrEMBL
    A0A3Q4L2S1
    Related
    ENSMUSP00000049319.6, ENSMUST00000044252.7
    Conserved Domains (1) summary
    pfam10609
    Location:17266
    ParA; NUBPL iron-transfer P-loop NTPase

RNA

  1. NR_166441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234293.2
  2. NR_166442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234261.2
  3. NR_166443.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234352.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25101585..25105423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160624.1XP_036016517.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q4EGU9
    Related
    ENSMUSP00000157175.2, ENSMUST00000234968.2
    Conserved Domains (1) summary
    pfam10609
    Location:44256
    ParA; NUBPL iron-transfer P-loop NTPase