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ACTR3 actin related protein 3 [ Homo sapiens (human) ]

Gene ID: 10096, updated on 4-Oct-2020

Summary

Official Symbol
ACTR3provided by HGNC
Official Full Name
actin related protein 3provided by HGNC
Primary source
HGNC:HGNC:170
See related
Ensembl:ENSG00000115091 MIM:604222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP3
Summary
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in lymph node (RPKM 65.6), appendix (RPKM 59.7) and 24 other tissues See more
Orthologs

Genomic context

See ACTR3 in Genome Data Viewer
Location:
2q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113889934..113962596)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (114647511..114719131)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member F5 Neighboring gene microRNA 4782 Neighboring gene uncharacterized LOC105373570 Neighboring gene ACTR3 antisense RNA 1 Neighboring gene uncharacterized LOC100499194 Neighboring gene long intergenic non-protein coding RNA 1191 Neighboring gene selenophosphate synthetase 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments PubMed
Knockdown of ARP3 by shRNA inhibits HIV-1 infection in CEM-SS cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
Pr55(Gag) gag HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ARP3 actin-related protein 3 homolog (ACTR3) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin polymerization-dependent cell motility TAS
Traceable Author Statement
more info
PubMed 
asymmetric cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
meiotic chromosome movement towards spindle pole IEA
Inferred from Electronic Annotation
more info
 
meiotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
spindle localization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 protein complex TAS
Traceable Author Statement
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 3
Names
ARP3 actin related protein 3 homolog
actin-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277140.1NP_001264069.1  actin-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001264069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1, resulting in translation initiation at a downstream AUG and an isoform (2) that is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC110769, AI521063, AK316396
    Consensus CDS
    CCDS63000.1
    UniProtKB/TrEMBL
    B4DXW1
    Related
    ENSP00000444987.1, ENST00000535589.3
    Conserved Domains (1) summary
    PTZ00280
    Location:2366
    PTZ00280; Actin-related protein 3; Provisional
  2. NM_005721.5NP_005712.1  actin-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_005712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110769, AI521063, BC044590, DB453995
    Consensus CDS
    CCDS33277.1
    UniProtKB/Swiss-Prot
    P61158
    UniProtKB/TrEMBL
    A0A024RAI1
    Related
    ENSP00000263238.2, ENST00000263238.7
    Conserved Domains (1) summary
    PTZ00280
    Location:2417
    PTZ00280; Actin-related protein 3; Provisional

RNA

  1. NR_102318.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC110769, AI521063, AK300030, BC044590, DB453995

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    113889934..113962596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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