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Mia2 MIA SH3 domain ER export factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100912115, updated on 18-Sep-2024

Summary

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Official Symbol
Mia2provided by RGD
Official Full Name
MIA SH3 domain ER export factor 2provided by RGD
Primary source
RGD:6488546
See related
EnsemblRapid:ENSRNOG00000005101 AllianceGenome:RGD:6488546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mgea6; Ctage5
Summary
Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; and protein transport. Predicted to act upstream of or within cholesterol homeostasis and triglyceride homeostasis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Orthologous to human MIA2 (MIA SH3 domain ER export factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 408.4), Kidney (RPKM 298.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q23
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (82522398..82620136)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (76787508..76885246)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (80188721..80286918)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 6B Neighboring gene pinin, desmosome associated protein Neighboring gene small nucleolar RNA, H/ACA box 26 like 1 Neighboring gene F-box protein 33 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites. Pitman JL, et al. J Lipid Res, 2011 Oct. PMID 21807889, Free PMC Article
  2. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. Tanabe T, et al. Mol Biol Cell, 2016 Jul 1. PMID 27170179, Free PMC Article
  3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. Santos AJ, et al. J Cell Biol, 2016 May 9. PMID 27138255, Free PMC Article
  4. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Saito K, et al. Mol Biol Cell, 2011 Jul 1. PMID 21525241, Free PMC Article
  5. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. Saito K, et al. J Cell Biol, 2014 Sep 15. PMID 25202031, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma inhibitory activity protein 2
Names
CTAGE family member 5, ER export factor
CTAGE family, member 5
cutaneous T-cell lymphoma-associated antigen 5 homolog
melanoma inhibitory activity 2
meningioma expressed antigen 6 (coiled-coil proline-rich)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371341.1 → NP_001358270.1  melanoma inhibitory activity protein 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZSK4
    Related
    ENSRNOP00000081248.1, ENSRNOT00000103916.2
    Conserved Domains (3) summary
    PHA03247
    Location:1190 → 1400
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:671 → 1105
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl17036
    Location:31 → 103
    SH3; Src Homology 3 domain superfamily

  2. NM_001371347.1 → NP_001358276.1  melanoma inhibitory activity protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several coding exons and reflects the use of an alternate internal promoter, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct N-terminus, compared to isoform 1
    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D3ZVL1
    Conserved Domains (2) summary
    PHA03247
    Location:548 → 758
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:62 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    82522398..82620136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764679.4 → XP_008762901.2  melanoma inhibitory activity protein 2 isoform X4

  2. XM_017594453.3 → XP_017449942.1  melanoma inhibitory activity protein 2 isoform X5

  3. XM_039111595.2 → XP_038967523.1  melanoma inhibitory activity protein 2 isoform X10

    Conserved Domains (3) summary
    COG1196
    Location:771 → 1048
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:642 → 867
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cl17036
    Location:31 → 103
    SH3; Src Homology 3 domain superfamily

  4. XM_017594450.3 → XP_017449939.1  melanoma inhibitory activity protein 2 isoform X1

    UniProtKB/TrEMBL
    D3ZVK5
    Related
    ENSRNOP00000056080.5, ENSRNOT00000059318.6

  5. XM_063261379.1 → XP_063117449.1  melanoma inhibitory activity protein 2 isoform X6

  6. XM_008764680.4 → XP_008762902.2  melanoma inhibitory activity protein 2 isoform X7

    Related
    ENSRNOP00000070325.3, ENSRNOT00000089010.3

  7. XM_017594451.3 → XP_017449940.1  melanoma inhibitory activity protein 2 isoform X2

  8. XM_063261380.1 → XP_063117450.1  melanoma inhibitory activity protein 2 isoform X8

  9. XM_017594452.3 → XP_017449941.1  melanoma inhibitory activity protein 2 isoform X3

    Related
    ENSRNOP00000056095.5, ENSRNOT00000059335.5

  10. XM_039111594.2 → XP_038967522.1  melanoma inhibitory activity protein 2 isoform X9

    Conserved Domains (3) summary
    PHA03247
    Location:1114 → 1324
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:671 → 1027
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17036
    Location:31 → 103
    SH3; Src Homology 3 domain superfamily

  11. XM_063261383.1 → XP_063117453.1  melanoma inhibitory activity protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A0G2K2J9

  12. XM_003750164.6 → XP_003750212.1  melanoma inhibitory activity protein 2 isoform X17

    See identical proteins and their annotated locations for XP_003750212.1

    UniProtKB/TrEMBL
    A0A0G2K2J9, D3ZHI1
    Related
    ENSRNOP00000006995.6, ENSRNOT00000006995.10
    Conserved Domains (2) summary
    pfam06409
    Location:393 → 466
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl21478
    Location:165 → 263
    ATP-synt_B; ATP synthase B/B' CF(0)

  13. XM_063261386.1 → XP_063117456.1  melanoma inhibitory activity protein 2 isoform X27

    UniProtKB/TrEMBL
    A0A0G2K2J9

  14. XM_063261387.1 → XP_063117457.1  melanoma inhibitory activity protein 2 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JXM0

  15. XM_063261388.1 → XP_063117458.1  melanoma inhibitory activity protein 2 isoform X29

    UniProtKB/TrEMBL
    A0A0G2K2J9, A0A0G2KA58

  16. XM_063261389.1 → XP_063117459.1  melanoma inhibitory activity protein 2 isoform X30

    UniProtKB/TrEMBL
    A0A0G2JXM0

  17. XM_017594457.3 → XP_017449946.1  melanoma inhibitory activity protein 2 isoform X24

    UniProtKB/TrEMBL
    D3ZVL1

  18. XM_063261391.1 → XP_063117461.1  melanoma inhibitory activity protein 2 isoform X32

    UniProtKB/TrEMBL
    D3ZVL1

  19. XM_063261392.1 → XP_063117462.1  melanoma inhibitory activity protein 2 isoform X33

    UniProtKB/TrEMBL
    A0A0G2JXM0
    Related
    ENSRNOP00000103258.1, ENSRNOT00000152873.1

  20. XM_063261393.1 → XP_063117463.1  melanoma inhibitory activity protein 2 isoform X34

    UniProtKB/TrEMBL
    A0A0G2JXM0

  21. XM_017594454.3 → XP_017449943.1  melanoma inhibitory activity protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A0G2K2J9
    Related
    ENSRNOP00000072272.2, ENSRNOT00000086221.3

  22. XM_063261381.1 → XP_063117451.1  melanoma inhibitory activity protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K2J9
    Related
    ENSRNOP00000075271.3, ENSRNOT00000077435.3

  23. XM_039111596.2 → XP_038967524.1  melanoma inhibitory activity protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A0G2JXM0
    Conserved Domains (2) summary
    PHA03247
    Location:586 → 796
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:149 → 523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  24. XM_006240128.5 → XP_006240190.1  melanoma inhibitory activity protein 2 isoform X12

    See identical proteins and their annotated locations for XP_006240190.1

    UniProtKB/TrEMBL
    A0A0G2K2J9
    Conserved Domains (2) summary
    pfam06409
    Location:432 → 505
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl21478
    Location:204 → 302
    ATP-synt_B; ATP synthase B/B' CF(0)

  25. XM_063261382.1 → XP_063117452.1  melanoma inhibitory activity protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A0G2K2J9

  26. XM_006240132.5 → XP_006240194.1  melanoma inhibitory activity protein 2 isoform X20

    See identical proteins and their annotated locations for XP_006240194.1

    UniProtKB/TrEMBL
    A0A0G2JXM0
    Conserved Domains (2) summary
    pfam06409
    Location:432 → 505
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl21478
    Location:204 → 302
    ATP-synt_B; ATP synthase B/B' CF(0)

  27. XM_003750165.6 → XP_003750213.2  melanoma inhibitory activity protein 2 isoform X13

    See identical proteins and their annotated locations for XP_003750213.2

    UniProtKB/TrEMBL
    A6HBR5
    Conserved Domains (3) summary
    pfam06409
    Location:408 → 481
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam13949
    Location:212 → 481
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
    cl21478
    Location:180 → 278
    ATP-synt_B; ATP synthase B/B' CF(0)

  28. XM_063261384.1 → XP_063117454.1  melanoma inhibitory activity protein 2 isoform X23

    UniProtKB/TrEMBL
    A6HBR5

  29. XM_039111599.2 → XP_038967527.1  melanoma inhibitory activity protein 2 isoform X25

    UniProtKB/TrEMBL
    A6HBR5
    Conserved Domains (2) summary
    PHA03247
    Location:553 → 763
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:110 → 466
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  30. XM_039111598.2 → XP_038967526.1  melanoma inhibitory activity protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A0G2K2J9
    Conserved Domains (3) summary
    PHA03247
    Location:564 → 774
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:145 → 422
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:16 → 241
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

  31. XM_017594455.3 → XP_017449944.1  melanoma inhibitory activity protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A0G2K2J9
    Related
    ENSRNOP00000107055.1, ENSRNOT00000152614.1

  32. XM_063261385.1 → XP_063117455.1  melanoma inhibitory activity protein 2 isoform X26

    UniProtKB/TrEMBL
    A0A0G2K2J9

  33. XM_017594456.3 → XP_017449945.1  melanoma inhibitory activity protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A0G2K2J9

  34. XM_063261390.1 → XP_063117460.1  melanoma inhibitory activity protein 2 isoform X31

    UniProtKB/TrEMBL
    A0A0G2JXM0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106734.1: Suppressed sequence

    Description
    NM_001106734.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: CTAGE5 (GeneID:513132).
Nucleotide Protein Strain
Heading Accession and Version

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