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MIA2 MIA SH3 domain ER export factor 2 [ Homo sapiens (human) ]

Gene ID: 4253, updated on 12-Oct-2019

Summary

Official Symbol
MIA2provided by HGNC
Official Full Name
MIA SH3 domain ER export factor 2provided by HGNC
Primary source
HGNC:HGNC:18432
See related
Ensembl:ENSG00000150527 MIM:602132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA6; MGEA; TALI; MGEA6; CTAGE5; MGEA11
Summary
This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in small intestine (RPKM 22.6), duodenum (RPKM 22.5) and 25 other tissues See more
Orthologs

Genomic context

See MIA2 in Genome Data Viewer
Location:
14q21.1
Exon count:
39
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (39233915..39388522)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39734476..39820397)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein 92 pseudogene Neighboring gene YTH domain family member 2 pseudogene 1 Neighboring gene uncharacterized LOC100288846 Neighboring gene coilin pseudogene 1 Neighboring gene uncharacterized LOC105370461 Neighboring gene F-box protein 33 Neighboring gene uncharacterized LOC105370460 Neighboring gene uncharacterized LOC112267899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
    Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22404, FLJ31229, FLJ33933, FLJ55352, FLJ94735, FLJ96258, MGC59810, MGC75562, MGC163409, MGC163435, DKFZp313K0722, DKFZp686F2453, DKFZp686M2159, DKFZp779J1922, DKFZp779M1842, DKFZp686F08252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cargo loading into vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
melanoma inhibitory activity protein 2
Names
CTAGE family member 5, ER export factor
CTAGE family, member 5
TANGO1-like
cutaneous T-cell lymphoma-associated antigen 5
melanoma inhibitory activity 2
meningioma expressed antigen 6 (coiled-coil proline-rich)
meningioma-expressed antigen 6/11
protein cTAGE-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030349.3 RefSeqGene

    Range
    36371..122484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247988.1NP_001234917.1  melanoma inhibitory activity protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001234917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 5, which is shorter at the N-terminus and lacks two internal segments compared to isoform 6. Variants 5 and 12 both encode the same isoform (5).
    Source sequence(s)
    AF338233, AI521895, AK091252, AL132639, AL833415
    UniProtKB/Swiss-Prot
    O15320
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001247989.1NP_001234918.1  melanoma inhibitory activity protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6, also known as TALI).
    Source sequence(s)
    AI521895, AL132639, BC064355, CV809109
    Consensus CDS
    CCDS58316.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000379462.2, ENST00000396158.6
    Conserved Domains (4) summary
    pfam06409
    Location:403476
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10211
    Location:164230
    Ax_dynein_light; Axonemal dynein light chain
    pfam14662
    Location:325496
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    pfam15233
    Location:350448
    SYCE1; Synaptonemal complex central element protein 1
  3. NM_001247990.2NP_001234919.1  melanoma inhibitory activity protein 2 isoform 7

    See identical proteins and their annotated locations for NP_001234919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 6. The resulting isoform (7) is shorter at the N-terminus compared to isoform 6.
    Source sequence(s)
    AI521895, AL132639, BC051363, CV809109
    Consensus CDS
    CCDS58317.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000452562.1, ENST00000556148.5
    Conserved Domains (1) summary
    cl25732
    Location:2424
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001329214.3NP_001316143.1  melanoma inhibitory activity protein 2 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Consensus CDS
    CCDS86384.1
    UniProtKB/Swiss-Prot
    Q96PC5
    UniProtKB/TrEMBL
    A0A193H6U5
    Related
    ENSP00000491014.1, ENST00000640607.1
  5. NM_001354137.1NP_001341066.1  melanoma inhibitory activity protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 4 and 11, encodes isoform 4.
    Source sequence(s)
    AL132639
    Consensus CDS
    CCDS9676.1
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001354138.1NP_001341067.1  melanoma inhibitory activity protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 4 and 10, encodes isoform 4.
    Source sequence(s)
    AL132639
    Consensus CDS
    CCDS9676.1
    Related
    ENSP00000450449.1, ENST00000553352.1
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001354139.1NP_001341068.1  melanoma inhibitory activity protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001354140.2NP_001341069.1  melanoma inhibitory activity protein 2 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform 10.
    Source sequence(s)
    AL132639
    Consensus CDS
    CCDS86386.1
    Related
    ENSP00000450869.1, ENST00000557038.5
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001354141.2NP_001341070.1  melanoma inhibitory activity protein 2 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform 10.
    Source sequence(s)
    AL132639
    Consensus CDS
    CCDS86386.1
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001354142.1NP_001341071.1  melanoma inhibitory activity protein 2 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 16 and 17, encodes isoform 11.
    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001354143.1NP_001341072.1  melanoma inhibitory activity protein 2 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 15 and 17, encodes isoform 11.
    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001354144.2NP_001341073.1  melanoma inhibitory activity protein 2 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 15 and 16, encodes isoform 11.
    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001354145.2NP_001341074.1  melanoma inhibitory activity protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL132639, AL157791
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  14. NM_001354146.2NP_001341075.1  melanoma inhibitory activity protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:62487
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001354147.1NP_001341076.1  melanoma inhibitory activity protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:112405
    SMC_N; RecF/RecN/SMC N terminal domain
  16. NM_001354148.1NP_001341077.1  melanoma inhibitory activity protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL132639, AL157791
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain
  17. NM_001354149.1NP_001341078.1  melanoma inhibitory activity protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:112405
    SMC_N; RecF/RecN/SMC N terminal domain
  18. NM_001354150.2NP_001341079.1  melanoma inhibitory activity protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:68493
    SMC_N; RecF/RecN/SMC N terminal domain
  19. NM_001354151.2NP_001341080.1  melanoma inhibitory activity protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:74508
    SMC_N; RecF/RecN/SMC N terminal domain
  20. NM_001354152.2NP_001341081.1  melanoma inhibitory activity protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:74508
    SMC_N; RecF/RecN/SMC N terminal domain
  21. NM_001354153.2NP_001341082.1  melanoma inhibitory activity protein 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:141434
    SMC_N; RecF/RecN/SMC N terminal domain
  22. NM_001354154.2NP_001341083.1  melanoma inhibitory activity protein 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL132639, AL157791
    Consensus CDS
    CCDS86385.1
    Related
    ENSP00000339286.5, ENST00000341502.9
    Conserved Domains (1) summary
    cl25732
    Location:74499
    SMC_N; RecF/RecN/SMC N terminal domain
  23. NM_001354155.2NP_001341084.1  melanoma inhibitory activity protein 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL132639, AL157791
    Conserved Domains (1) summary
    cl25732
    Location:74499
    SMC_N; RecF/RecN/SMC N terminal domain
  24. NM_001354156.2NP_001341085.1  melanoma inhibitory activity protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:1338
    SMC_N; RecF/RecN/SMC N terminal domain
  25. NM_001354157.2NP_001341086.1  melanoma inhibitory activity protein 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL132639
    Conserved Domains (1) summary
    cl25732
    Location:141434
    SMC_N; RecF/RecN/SMC N terminal domain
  26. NM_005930.4NP_005921.2  melanoma inhibitory activity protein 2 isoform 1

    See identical proteins and their annotated locations for NP_005921.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 1, which lacks an internal segment compared to isoform 6.
    Source sequence(s)
    AB209528, AL132639, CV809109, U94780
    Consensus CDS
    CCDS9674.1
    UniProtKB/Swiss-Prot
    O15320
    UniProtKB/TrEMBL
    Q59FD2
    Related
    ENSP00000280083.3, ENST00000280083.7
    Conserved Domains (4) summary
    pfam06409
    Location:398471
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10211
    Location:159225
    Ax_dynein_light; Axonemal dynein light chain
    pfam14662
    Location:320491
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    pfam15233
    Location:345443
    SYCE1; Synaptonemal complex central element protein 1
  27. NM_054024.4NP_473365.3  melanoma inhibitory activity protein 2 isoform 9 precursor

    See identical proteins and their annotated locations for NP_473365.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has lacks several 3' exons and differs in the 3' coding region and 3' UTR, compared to variant 6. It encodes isoform 8, which has a shorter and distinct C-terminus, compared to isoform 6.
    Source sequence(s)
    AF390175, AK026057, AL132639, BX495701, BX648228
    Consensus CDS
    CCDS9672.1
    UniProtKB/Swiss-Prot
    Q96PC5
    Related
    ENSP00000280082.3, ENST00000280082.4
    Conserved Domains (1) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
  28. NM_203354.3NP_976229.1  melanoma inhibitory activity protein 2 isoform 2

    See identical proteins and their annotated locations for NP_976229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 2, which has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 6.
    Source sequence(s)
    AB209528, AL132639, DA072098
    Consensus CDS
    CCDS9673.1
    UniProtKB/Swiss-Prot
    O15320
    UniProtKB/TrEMBL
    Q59FD2
    Related
    ENSP00000343897.3, ENST00000341749.7
    Conserved Domains (3) summary
    pfam06409
    Location:386459
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10211
    Location:147213
    Ax_dynein_light; Axonemal dynein light chain
    pfam15233
    Location:333431
    SYCE1; Synaptonemal complex central element protein 1
  29. NM_203355.3NP_976230.1  melanoma inhibitory activity protein 2 isoform 3

    See identical proteins and their annotated locations for NP_976230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 3, which lacks two internal segments and is shorter, compared to isoform 6.
    Source sequence(s)
    AL132639, BC029513, CV809109
    Consensus CDS
    CCDS9675.1
    UniProtKB/TrEMBL
    Q4G155
    Related
    ENSP00000343912.3, ENST00000348007.7
    Conserved Domains (4) summary
    pfam06409
    Location:398471
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10211
    Location:159225
    Ax_dynein_light; Axonemal dynein light chain
    pfam14662
    Location:320491
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    pfam15233
    Location:345443
    SYCE1; Synaptonemal complex central element protein 1
  30. NM_203356.2NP_976231.1  melanoma inhibitory activity protein 2 isoform 4

    See identical proteins and their annotated locations for NP_976231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, initiates translation at a downstream start codon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 4, which is shorter at the N-terminus and lacks an internal segment compared to isoform 6. Unlike the other variants, this variant may exhibit testis-specific expression. Variants 4, 10, and 11 all encode the same isoform (4).
    Source sequence(s)
    AF338233, AL132639
    Consensus CDS
    CCDS9676.1
    UniProtKB/Swiss-Prot
    O15320
    Related
    ENSP00000379468.4, ENST00000396165.8
    Conserved Domains (1) summary
    cl25732
    Location:45470
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_148721.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132639
  2. NR_148722.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132639
  3. NR_148723.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132639

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    39233915..39388522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449592.1XP_024305360.1  melanoma inhibitory activity protein 2 isoform X1

    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821121
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024449595.1XP_024305363.1  melanoma inhibitory activity protein 2 isoform X4

    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821121
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024449594.1XP_024305362.1  melanoma inhibitory activity protein 2 isoform X3

    Related
    ENSP00000452252.1, ENST00000553728.1
    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821112
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_024449593.1XP_024305361.1  melanoma inhibitory activity protein 2 isoform X2

    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821116
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_024449596.1XP_024305364.1  melanoma inhibitory activity protein 2 isoform X5

    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821107
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024449597.1XP_024305365.1  melanoma inhibitory activity protein 2 isoform X6

    Conserved Domains (2) summary
    cd11892
    Location:31103
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    cl25732
    Location:6821121
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_017021316.1XP_016876805.1  melanoma inhibitory activity protein 2 isoform X9

  8. XM_011536778.2XP_011535080.1  melanoma inhibitory activity protein 2 isoform X10

    Conserved Domains (3) summary
    pfam06409
    Location:395468
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10211
    Location:156222
    Ax_dynein_light; Axonemal dynein light chain
    pfam15233
    Location:342440
    SYCE1; Synaptonemal complex central element protein 1
  9. XM_017021324.2XP_016876813.1  melanoma inhibitory activity protein 2 isoform X12

    Conserved Domains (1) summary
    cl25732
    Location:5433
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_011536785.2XP_011535087.1  melanoma inhibitory activity protein 2 isoform X13

    See identical proteins and their annotated locations for XP_011535087.1

    UniProtKB/Swiss-Prot
    O15320
    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_017021327.1XP_016876816.1  melanoma inhibitory activity protein 2 isoform X14

    Conserved Domains (1) summary
    cl25732
    Location:87380
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_017021317.2XP_016876806.1  melanoma inhibitory activity protein 2 isoform X11

  13. XM_024449598.1XP_024305366.1  melanoma inhibitory activity protein 2 isoform X12

    Conserved Domains (1) summary
    cl25732
    Location:5433
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_017021315.2XP_016876804.1  melanoma inhibitory activity protein 2 isoform X8

  15. XM_017021330.1XP_016876819.1  melanoma inhibitory activity protein 2 isoform X11

  16. XM_017021318.1XP_016876807.1  melanoma inhibitory activity protein 2 isoform X11

  17. XM_017021314.1XP_016876803.1  melanoma inhibitory activity protein 2 isoform X7

  18. XM_017021319.1XP_016876808.1  melanoma inhibitory activity protein 2 isoform X11

  19. XM_017021323.1XP_016876812.1  melanoma inhibitory activity protein 2 isoform X12

    Conserved Domains (1) summary
    cl25732
    Location:5433
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_002957555.1 RNA Sequence

  2. XR_002957554.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203357.1: Suppressed sequence

    Description
    NM_203357.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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