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PLCB2 phospholipase C beta 2 [ Canis lupus familiaris (dog) ]

Gene ID: 100856190, updated on 17-Aug-2024

Summary

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Official Symbol
PLCB2provided by VGNC
Official Full Name
phospholipase C beta 2provided by VGNC
Primary source
VGNC:VGNC:44645
See related
Ensembl:ENSCAFG00845027587
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
34
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (7598044..7618970, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (7526161..7547075, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (7757123..7778226, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (7522589..7543490, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (7628543..7649438, complement)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157096 Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63 Neighboring gene InaF motif containing 2 Neighboring gene coiled-coil domain containing 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    7598044..7618970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441957.1 → XP_038297885.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PJS7, A0A8C0TUN2
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  2. XM_038441960.1 → XP_038297888.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Related
    ENSCAFP00845038294.1, ENSCAFT00845048808.1
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:981 → 1155
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  3. XM_038441959.1 → XP_038297887.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8I3S6D4, A0A8P0P0X8, A0A8P0SE12
    Related
    ENSCAFP00845038165.1, ENSCAFT00845048651.1
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  4. XM_038441958.1 → XP_038297886.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:989 → 1163
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  5. XM_038441961.1 → XP_038297889.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JWN7
    Conserved Domains (3) summary
    cd15898
    Location:149 → 178
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:149 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam17787
    Location:12 → 141
    PH_14; PH domain

RNA

  1. XR_005304692.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    7522589..7543490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516449.1 → XP_038372377.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  2. XM_038516452.1 → XP_038372380.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:981 → 1155
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  3. XM_038516451.1 → XP_038372379.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  4. XM_038516450.1 → XP_038372378.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:989 → 1163
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  5. XM_038516453.1 → XP_038372381.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    Conserved Domains (3) summary
    cd15898
    Location:149 → 178
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:149 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam17787
    Location:12 → 141
    PH_14; PH domain

RNA

  1. XR_005347765.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    7628543..7649438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644313.1 → XP_038500241.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

  2. XM_038644316.1 → XP_038500244.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

  3. XM_038644315.1 → XP_038500243.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

  4. XM_038644314.1 → XP_038500242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

  5. XM_038644317.1 → XP_038500245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    Conserved Domains (3) summary
    cd15898
    Location:149 → 178
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:149 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam17787
    Location:12 → 141
    PH_14; PH domain

RNA

  1. XR_005415323.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    7757123..7778226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580039.1 → XP_038435967.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PJS7, A0A8C0TUN2
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  2. XM_038580042.1 → XP_038435970.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:981 → 1155
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  3. XM_038580041.1 → XP_038435969.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8I3S6D4, A0A8P0P0X8, A0A8P0SE12
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  4. XM_038580040.1 → XP_038435968.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:989 → 1163
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  5. XM_038580043.1 → XP_038435971.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JWN7
    Conserved Domains (3) summary
    cd15898
    Location:149 → 178
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:149 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam17787
    Location:12 → 141
    PH_14; PH domain

RNA

  1. XR_005381507.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7526161..7547075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022412696.2 → XP_022268404.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PJS7, A0A8C0TUN2
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  2. XM_038461468.1 → XP_038317396.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:981 → 1155
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  3. XM_038461467.1 → XP_038317395.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8I3S6D4, A0A8P0P0X8, A0A8P0SE12
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:982 → 1156
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  4. XM_038461465.1 → XP_038317393.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RST6, A0A8I3Q1R1, A0A8P0P0X8
    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam08703
    Location:989 → 1163
    PLC-beta_C; PLC-beta C terminal
    pfam17787
    Location:12 → 141
    PH_14; PH domain

  5. XM_022412699.2 → XP_022268407.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JWN7
    Conserved Domains (3) summary
    cd15898
    Location:149 → 178
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:149 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam17787
    Location:12 → 141
    PH_14; PH domain

RNA

  1. XR_005316451.1 RNA Sequence

Nucleotide Protein
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