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DPP3 dipeptidyl peptidase 3 [ Homo sapiens (human) ]

Gene ID: 10072, updated on 2-Nov-2024

Summary

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Official Symbol
DPP3provided by HGNC
Official Full Name
dipeptidyl peptidase 3provided by HGNC
Primary source
HGNC:HGNC:3008
See related
Ensembl:ENSG00000254986 MIM:606818; AllianceGenome:HGNC:3008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPPIII
Summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

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See DPP3 in Genome Data Viewer
Location:
11q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66480434..66509657)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66476691..66505896)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66247905..66277128)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232341-66232842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232843-66233342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66245199-66245792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66246731-66247298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5045 Neighboring gene DPP3 divergent transcript Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66258390-66259340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5046 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene zinc finger DHHC-type containing 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298267-66298846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298847-66299424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66307071-66307841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5049 Neighboring gene Sharpr-MPRA regulatory region 1034 Neighboring gene actinin alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tumor cytosol dipeptidyl peptidase III activity is increased with histological aggressiveness of ovarian primary carcinomas. Simaga S, et al. Gynecol Oncol, 2003 Oct. PMID 14529681
  2. Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III. Agić D, et al. J Biomol Struct Dyn, 2019 Sep. PMID 30198396
  3. Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Cruz-Diaz N, et al. Peptides, 2016 Sep. PMID 27315786, Free PMC Article
  4. Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro. Prajapati SC, et al. Mol Biol Rep, 2016 Jun. PMID 27153830
  5. Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. Kumar P, et al. Sci Rep, 2016 Mar 30. PMID 27025154, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression].
    Title: [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression].
  2. DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
    Title: DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
  3. Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for diagnostics in COVID-19 and association with pulmonary infiltrates.
    Title: Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for diagnostics in COVID-19 and association with pulmonary infiltrates.
  4. Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma.
    Title: Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma.
  5. Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III.
    Title: Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III.
  6. The emerging role of dipeptidyl peptidase 3 in pathophysiology.
    Title: The emerging role of dipeptidyl peptidase 3 in pathophysiology.
  7. A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: 'DPP-3'.
    Title: A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: 'DPP-3'.
  8. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
    Title: DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
  9. Dipeptidyl Peptidase 3 Activity as a Promising Biomarker of Bone Fragility in Postmenopausal Women.
    Title: Dipeptidyl Peptidase 3 Activity as a Promising Biomarker of Bone Fragility in Postmenopausal Women.
  10. DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration.
    Title: DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11387, FLJ22331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
dipeptidyl peptidase 3
Names
DPP III
dipeptidyl aminopeptidase III
dipeptidyl arylamidase III
dipeptidyl peptidase III
enkephalinase B
NP_001243599.1
NP_005691.2
NP_569710.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032068.1 RefSeqGene

    Range
    5026..34249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256670.2 → NP_001243599.1  dipeptidyl peptidase 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ271216, AK297199, AK315478, DC407885
    Consensus CDS
    CCDS58147.1
    UniProtKB/TrEMBL
    Q5JPB8
    Related
    ENSP00000436941.1, ENST00000530165.5
    Conserved Domains (1) summary
    pfam03571
    Location:117 → 674
    Peptidase_M49; Peptidase family M49

  2. NM_005700.5 → NP_005691.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_005691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AJ271216, AK315478, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    B2RDB5, B4DLX4, F5H8L6, O95748, Q969H2, Q9BV67, Q9HAL6, Q9NY33
    UniProtKB/TrEMBL
    Q5JPB8
    Related
    ENSP00000435284.1, ENST00000532677.5
    Conserved Domains (1) summary
    pfam03571
    Location:147 → 704
    Peptidase_M49; Peptidase family M49

  3. NM_130443.4 → NP_569710.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_569710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL833475, BC024271, CD366941, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    B2RDB5, B4DLX4, F5H8L6, O95748, Q969H2, Q9BV67, Q9HAL6, Q9NY33
    UniProtKB/TrEMBL
    Q5JPB8
    Related
    ENSP00000432782.2, ENST00000531863.6
    Conserved Domains (1) summary
    pfam03571
    Location:147 → 704
    Peptidase_M49; Peptidase family M49

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66480434..66509657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66476691..66505896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NY33.2 GenPept UniProtKB/Swiss-Prot:Q9NY33

Gene LinkOut

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