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DPP3 dipeptidyl peptidase 3 [ Homo sapiens (human) ]

Gene ID: 10072, updated on 1-Jun-2020

Summary

Official Symbol
DPP3provided by HGNC
Official Full Name
dipeptidyl peptidase 3provided by HGNC
Primary source
HGNC:HGNC:3008
See related
Ensembl:ENSG00000254986 MIM:606818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPPIII
Summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See DPP3 in Genome Data Viewer
Location:
11q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66480434..66509657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66247484..66277130)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene uncharacterized LOC101928069 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene zinc finger DHHC-type containing 24 Neighboring gene actinin alpha 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11387, FLJ22331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
dipeptidyl peptidase 3
Names
DPP III
dipeptidyl aminopeptidase III
dipeptidyl arylamidase III
dipeptidyl peptidase III
enkephalinase B
NP_001243599.1
NP_005691.2
NP_569710.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032068.1 RefSeqGene

    Range
    5026..34249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256670.2NP_001243599.1  dipeptidyl peptidase 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ271216, AK297199, AK315478, DC407885
    Consensus CDS
    CCDS58147.1
    UniProtKB/Swiss-Prot
    Q9NY33
    Related
    ENSP00000436941.1, ENST00000530165.5
    Conserved Domains (1) summary
    pfam03571
    Location:117674
    Peptidase_M49; Peptidase family M49
  2. NM_005700.5NP_005691.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_005691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AJ271216, AK315478, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    Q9NY33
    Related
    ENSP00000435284.1, ENST00000532677.5
    Conserved Domains (1) summary
    pfam03571
    Location:147704
    Peptidase_M49; Peptidase family M49
  3. NM_130443.4NP_569710.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_569710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL833475, BC024271, CD366941, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    Q9NY33
    UniProtKB/TrEMBL
    Q5JPB8
    Related
    ENSP00000440502.1, ENST00000541961.5
    Conserved Domains (1) summary
    pfam03571
    Location:147704
    Peptidase_M49; Peptidase family M49

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66480434..66509657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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