Dpp3 dipeptidylpeptidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp3provided by MGI
Official Full Name: dipeptidylpeptidase 3provided by MGI
Primary source: MGI:MGI:1922471
See related: Ensembl:ENSMUSG00000063904 AllianceGenome:MGI:1922471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DPP III; 4930533O14Rik
Summary: Predicted to enable dipeptidyl-peptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DPP3 (dipeptidyl peptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 86.3), colon adult (RPKM 70.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19; 19 A

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4957257..4978315, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4907229..4928287, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
Title: DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.
Title: Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.
Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
Title: Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
Title: Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
the cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation
Title: Peptidases released by necrotic cells control CD8+ T cell cross-priming.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C86324 (e-PCR)
- UniSTS:209424

AW821961 (e-PCR)
- UniSTS:209426

SHGC-59694 (e-PCR)
- UniSTS:40904

Homology

Homologs of the Dpp3 gene: The Dpp3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 389 organisms have orthologs with human gene Dpp3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 3

Names: dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase III; dipeptidyl-peptidase 3; dipeptidylpeptidase III; enkephalinase B

NP_001347640.1

EC 3.4.14.4

NP_598564.2

EC 3.4.14.4

XP_036017612.1

EC 3.4.14.4

XP_036017613.1

EC 3.4.14.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360711.1 → NP_001347640.1 dipeptidyl peptidase 3

Status: VALIDATED

Source sequence(s)

AC124502, AC141437

Consensus CDS

CCDS29443.1

UniProtKB/Swiss-Prot

Q8C0I6

Conserved Domains (1) summary

pfam03571
Location:147 → 704

Peptidase_M49; Peptidase family M49
NM_133803.2 → NP_598564.2 dipeptidyl peptidase 3

See identical proteins and their annotated locations for NP_598564.2

Status: VALIDATED

Source sequence(s)

AK031020, AK150101, BY131486

Consensus CDS

CCDS29443.1

UniProtKB/Swiss-Prot

Q8C0I6, Q99KK7

UniProtKB/TrEMBL

Q3UDF3

Related

ENSMUSP00000025851.4, ENSMUST00000025851.4

Conserved Domains (1) summary

pfam03571
Location:147 → 704

Peptidase_M49; Peptidase family M49

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

4957257..4978315 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161719.1 → XP_036017612.1 dipeptidyl peptidase 3 isoform X1

Conserved Domains (1) summary

pfam03571
Location:1 → 427

Peptidase_M49; Peptidase family M49
XM_036161720.1 → XP_036017613.1 dipeptidyl peptidase 3 isoform X1

Conserved Domains (1) summary

pfam03571
Location:1 → 427

Peptidase_M49; Peptidase family M49