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Upk3b uroplakin 3B [ Mus musculus (house mouse) ]

Gene ID: 100647, updated on 16-Mar-2024

Summary

Official Symbol
Upk3bprovided by MGI
Official Full Name
uroplakin 3Bprovided by MGI
Primary source
MGI:MGI:2140882
See related
Ensembl:ENSMUSG00000042985 AllianceGenome:MGI:2140882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P35; UpIIIb; PMS2L14
Summary
Involved in negative regulation of glucose import. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in heart; intraembryonic coelom; proepicardium; and urinary system. Orthologous to human UPK3B (uroplakin 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 78.2), lung adult (RPKM 49.7) and 13 other tissues See more
Orthologs
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Genomic context

See Upk3b in Genome Data Viewer
Location:
5 G2; 5 75.7 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136067350..136073847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136038496..136044993)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 3 Neighboring gene deltex 2, E3 ubiquitin ligase Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene RAS p21 protein activator 4 Neighboring gene microRNA 7035

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uroplakin-3b
Names
UP3b
uroplakin IIIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175309.4NP_780518.1  uroplakin-3b precursor

    See identical proteins and their annotated locations for NP_780518.1

    Status: VALIDATED

    Source sequence(s)
    AK052525
    Consensus CDS
    CCDS19750.1
    UniProtKB/Swiss-Prot
    Q0VBK9, Q6P8J5, Q80YF6, Q8BGL8
    UniProtKB/TrEMBL
    A0A0R4J0S8
    Related
    ENSMUSP00000062312.7, ENSMUST00000062606.8
    Conserved Domains (1) summary
    cd09969
    Location:29204
    UP_IIIb; Uroplakin IIIb

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136067350..136073847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)