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UPK3B uroplakin 3B [ Homo sapiens (human) ]

Gene ID: 105375355, updated on 1-Jun-2020

Summary

Official Symbol
UPK3Bprovided by HGNC
Official Full Name
uroplakin 3Bprovided by HGNC
Primary source
HGNC:HGNC:21444
See related
Ensembl:ENSG00000243566 MIM:611887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P35; UP3B; UPIIIB
Summary
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in lung (RPKM 16.8), urinary bladder (RPKM 3.5) and 2 other tissues See more
Orthologs

Genomic context

See UPK3B in Genome Data Viewer
Location:
7q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (76510552..76516522)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene zona pellucida glycoprotein 3 Neighboring gene deltex E3 ubiquitin ligase 2 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene speedy/RINGO cell cycle regulator family member E16 Neighboring gene uncharacterized LOC100133091 Neighboring gene 7q11.23 distal recombination region Neighboring gene POM121 and ZP3 fusion

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ32198, FLJ75011, MGC10902

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uroplakin-3b
Names
uroplakin IIIb

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347684.2NP_001334613.1  uroplakin-3b isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) is alternatively spliced at the 5' end, differs in the 3' UTR and contains an additional internal exon, which causes a frame-shift compared to variant 1. The resulting isoform (d) lacks a protein segment in the N-terminal region and has a distinct C-terminus compared to isoform a. This variant is annotated on the GRCh38 primary human reference genome assembly.
    Source sequence(s)
    AC004980, AC007078
    Consensus CDS
    CCDS87512.1
    UniProtKB/Swiss-Prot
    Q9BT76
    Related
    ENSP00000334938.3, ENST00000334348.7
  2. NM_030570.3NP_085047.1  uroplakin-3b isoform a precursor

    See identical proteins and their annotated locations for NP_085047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). This variant is annotated on the ALT_REF_LOCI_1 alternate haplotype of the GRCh38 human reference genome assembly.
    Source sequence(s)
    BC004304, BE615406, BP352210, BU150542
    UniProtKB/Swiss-Prot
    Q9BT76
    Conserved Domains (1) summary
    cl06408
    Location:84209
    UP_III_II; Uroplakin IIIb, IIIa and II
  3. NM_182683.2NP_872624.1  uroplakin-3b isoform c precursor

    See identical proteins and their annotated locations for NP_872624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 5' end compared to variant 1, which results in a shorter isoform (c) lacking a protein segment in the N-terminal region compared to isoform a. This variant is annotated on the ALT_REF_LOCI_1 alternate haplotype of the GRCh38 human reference genome assembly.
    Source sequence(s)
    AY233462, BE615406, BP352210, BU150542
    UniProtKB/Swiss-Prot
    Q9BT76
    UniProtKB/TrEMBL
    A0A0J9YVS6
    Conserved Domains (1) summary
    cl06408
    Location:29154
    UP_III_II; Uroplakin IIIb, IIIa and II
  4. NM_182684.2NP_872625.1  uroplakin-3b isoform b precursor

    See identical proteins and their annotated locations for NP_872625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' end and contains an additional internal exon, which causes a frame-shift compared to variant 1. The resulting isoform (b) lacks a protein segment in the N-terminal region and has a distinct C-terminus compared to isoform a. This variant is annotated on the ALT_REF_LOCI_1 alternate haplotype of the GRCh38 human reference genome assembly.
    Source sequence(s)
    AY233462, BE615406, BP352210, BU150542
    UniProtKB/Swiss-Prot
    Q9BT76
    Conserved Domains (1) summary
    cd09969
    Location:29202
    UP_IIIb; Uroplakin IIIb

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    76510552..76516522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187561.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    9510..14763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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