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RPS10-NUDT3 RPS10-NUDT3 readthrough [ Homo sapiens (human) ]

Gene ID: 100529239, updated on 5-Jan-2022

Summary

Official Symbol
RPS10-NUDT3provided by HGNC
Official Full Name
RPS10-NUDT3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:49181
See related
Ensembl:ENSG00000270800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring RPS10 (ribosomal protein S10) and NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) genes on chromosome 6. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in ovary (RPKM 198.0), lymph node (RPKM 141.3) and 25 other tissues See more
Orthologs
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Genomic context

See RPS10-NUDT3 in Genome Data Viewer
Location:
6p21.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (34287194..34426069, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34254971..34393846, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 29 Neighboring gene ribosomal protein L35 pseudogene 2 Neighboring gene nudix hydrolase 3 Neighboring gene ribosomal protein S10 Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene Sharpr-MPRA regulatory region 1455 Neighboring gene SAM pointed domain containing ETS transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
RPS10-NUDT3 protein
Names
ribosomal protein S10 homologue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202470.3NP_001189399.1  RPS10-NUDT3 protein

    Status: REVIEWED

    Source sequence(s)
    AL157372, BU521288, Z98036
    UniProtKB/TrEMBL
    A0A1W2PQS6
    Related
    ENSP00000492441.1, ENST00000639725.1
    Conserved Domains (2) summary
    cd04666
    Location:153250
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    pfam03501
    Location:397
    S10_plectin; Plectin/S10 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    34287194..34426069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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