pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: pik3r1provided by Xenbase
Official Full Name: phosphoinositide-3-kinase regulatory subunit 1provided by Xenbase
Primary source: Xenbase:XB-GENE-6067221
See related: Ensembl:ENSXETG00000021480
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: grb1; pik3r1-a; pik3r1-b; p85-alpha
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (186676178..186717169, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (173906559..173948056, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit alpha

Names: phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

186676178..186717169 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002934186.5 → XP_002934232.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/TrEMBL

F6Z0J4

Related

ENSXETP00000046442.3, ENSXETT00000046442.3

Conserved Domains (5) summary

cd09930
Location:615 → 718

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 434

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 80

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:439 → 598

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:113 → 307

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...
XM_004910380.4 → XP_004910437.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

UniProtKB/TrEMBL

A0A6I8SVB1

Related

ENSXETP00000097106.1, ENSXETT00000081262.2

Conserved Domains (5) summary

cd09930
Location:567 → 670

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:277 → 386

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:391 → 550

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:65 → 259

RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

pfam16454
Location:390 → 549

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
XM_004910381.4 → XP_004910438.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

UniProtKB/TrEMBL

A0A8J0QZS8

Conserved Domains (3) summary

cd09930
Location:356 → 459

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:66 → 175

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:180 → 339

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
XM_004910382.4 → XP_004910439.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

UniProtKB/TrEMBL

A0A6I8S9W3

Related

ENSXETP00000089438.2, ENSXETT00000096967.2

Conserved Domains (4) summary

cd09930
Location:346 → 449

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:56 → 165

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:170 → 329

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

pfam16454
Location:169 → 328

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain