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Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 18708, updated on 5-Jun-2018
Official Symbol
Pik3r1provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 1provided by MGI
Primary source
MGI:MGI:97583
See related
Ensembl:ENSMUSG00000041417 Vega:OTTMUSG00000048150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI3K; p50alpha; p55alpha; p85alpha
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 14.1), mammary gland adult (RPKM 12.9) and 27 other tissues See more
Orthologs
See Pik3r1 in Genome Data Viewer
Location:
13 D1; 13 53.92 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (101680761..101768217, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (102450716..102538172, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36475 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene predicted gene, 36553 Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene ezrin pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • C530050K14

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to 1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
1-phosphatidylinositol-3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of phosphatidylinositol 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cAMP ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase complex TAS
Traceable Author Statement
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
PI3-kinase subunit p85-alpha
PI3K regulatory subunit alpha
phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024955.2NP_001020126.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001020126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (1) has a shorter and distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AI838690, AK046259, AK138868, AK164783, BM963795, CB519962
    Consensus CDS
    CCDS26740.1
    UniProtKB/TrEMBL
    Q3TP23, Q80UI5, Q8C7P2
    Related
    ENSMUSP00000047004.6, OTTMUSP00000067469, ENSMUST00000035532.12, OTTMUST00000123677
    Conserved Domains (4) summary
    cd09930
    Location:347450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:58165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:169328
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
  2. NM_001077495.2NP_001070963.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_001070963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC107663, AC153139, AI838690, AK046259, AK138868, AK164783, BB647657, BM963795, CB519962, CF169061
    Consensus CDS
    CCDS36769.1
    UniProtKB/Swiss-Prot
    P26450
    UniProtKB/TrEMBL
    Q3TP23, Q8C7P2
    Related
    ENSMUSP00000056774.6, OTTMUSP00000067463, ENSMUST00000055518.12, OTTMUST00000123661
    Conserved Domains (6) summary
    cd09930
    Location:617720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:328435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:579
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:115302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:439598
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    101680761..101768217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517569.3XP_006517632.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006517632.1

    Conserved Domains (3) summary
    cd09930
    Location:317420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:28135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
  2. XM_006517570.3XP_006517633.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (4) summary
    cd09930
    Location:296399
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:4114
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:119279
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:118277
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
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