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RANBP9 RAN binding protein 9 [ Homo sapiens (human) ]

Gene ID: 10048, updated on 4-May-2020

Summary

Official Symbol
RANBP9provided by HGNC
Official Full Name
RAN binding protein 9provided by HGNC
Primary source
HGNC:HGNC:13727
See related
Ensembl:ENSG00000010017 MIM:603854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPM-L; BPM90; RANBPM; RanBP7
Summary
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues See more
Orthologs

Genomic context

See RANBP9 in Genome Data Viewer
Location:
6p23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (13621498..13711835, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13621730..13711796, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374937 Neighboring gene sirtuin 5 Neighboring gene uncharacterized LOC105374938 Neighboring gene nucleolar protein 7 Neighboring gene Sharpr-MPRA regulatory region 2979 Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene uncharacterized LOC107986571

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ran GTPase binding TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule nucleation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ran-binding protein 9
Names
Ran Binding Protein in the Microtubule organizing center
novel centrosomal protein RanBPM
ran binding protein, centrosomal
ran-binding protein M

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005493.3NP_005484.2  ran-binding protein 9

    See identical proteins and their annotated locations for NP_005484.2

    Status: REVIEWED

    Source sequence(s)
    AB055311, AF306510, BC052781, Z93020
    Consensus CDS
    CCDS4529.1
    UniProtKB/Swiss-Prot
    Q96S59
    UniProtKB/TrEMBL
    A0A024QZW3
    Related
    ENSP00000011619.3, ENST00000011619.6
    Conserved Domains (5) summary
    smart00667
    Location:364397
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:403459
    CTLH; C-terminal to LisH motif
    smart00757
    Location:616708
    CRA; CT11-RanBPM
    pfam10607
    Location:403457
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:189331
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    13621498..13711835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514205.2XP_011512507.1  ran-binding protein 9 isoform X1

    Conserved Domains (5) summary
    smart00667
    Location:364397
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:403459
    CTLH; C-terminal to LisH motif
    smart00757
    Location:526618
    CRA; CT11-RanBPM
    pfam10607
    Location:403618
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:189331
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
  2. XM_006714945.2XP_006715008.1  ran-binding protein 9 isoform X3

    See identical proteins and their annotated locations for XP_006715008.1

    UniProtKB/Swiss-Prot
    Q96S59
    Conserved Domains (4) summary
    smart00667
    Location:135168
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:387479
    CRA; CT11-RanBPM
    cd12909
    Location:1102
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    pfam10607
    Location:174228
    CLTH; CTLH/CRA C-terminal to LisH motif domain
  3. XM_017010149.1XP_016865638.1  ran-binding protein 9 isoform X2

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