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RANBP9 RAN binding protein 9 [ Homo sapiens (human) ]

Gene ID: 10048, updated on 4-Dec-2022

Summary

Official Symbol
RANBP9provided by HGNC
Official Full Name
RAN binding protein 9provided by HGNC
Primary source
HGNC:HGNC:13727
See related
Ensembl:ENSG00000010017 MIM:603854; AllianceGenome:HGNC:13727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPM-L; BPM90; RANBPM; RanBP7
Summary
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues See more
Orthologs
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Genomic context

See RANBP9 in Genome Data Viewer
Location:
6p23
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13621498..13711835, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13495055..13585361, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13621730..13712067, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene sirtuin 5 Neighboring gene uncharacterized LOC105374938 Neighboring gene uncharacterized LOC124901263 Neighboring gene nucleolar protein 7 Neighboring gene U7 small nuclear RNA Neighboring gene Sharpr-MPRA regulatory region 12249 Neighboring gene uncharacterized LOC124901264 Neighboring gene Sharpr-MPRA regulatory region 2979

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ran-binding protein 9
Names
Ran Binding Protein in the Microtubule organizing center
novel centrosomal protein RanBPM
ran binding protein, centrosomal
ran-binding protein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005493.3NP_005484.2  ran-binding protein 9

    See identical proteins and their annotated locations for NP_005484.2

    Status: REVIEWED

    Source sequence(s)
    AB055311, AF306510, BC052781, Z93020
    Consensus CDS
    CCDS4529.1
    UniProtKB/Swiss-Prot
    Q7Z7F9, Q96S59
    UniProtKB/TrEMBL
    A0A024QZW3
    Related
    ENSP00000011619.3, ENST00000011619.6
    Conserved Domains (4) summary
    smart00667
    Location:364397
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:616708
    CRA; CT11-RanBPM
    cd12909
    Location:189331
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    pfam10607
    Location:403457
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    13621498..13711835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514205.3XP_011512507.1  ran-binding protein 9 isoform X1

    Conserved Domains (5) summary
    smart00667
    Location:364397
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:403459
    CTLH; C-terminal to LisH motif
    smart00757
    Location:526618
    CRA; CT11-RanBPM
    pfam10607
    Location:403618
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:189331
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
  2. XM_047418032.1XP_047273988.1  ran-binding protein 9 isoform X3

  3. XM_017010149.2XP_016865638.1  ran-binding protein 9 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    13495055..13585361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)