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DUS2 dihydrouridine synthase 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100354521, updated on 3-Apr-2024

Summary

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Gene symbol
DUS2
Gene description
dihydrouridine synthase 2
See related
Ensembl:ENSOCUG00000010043
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
DUS2L
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 5 NC_067378.1 (23565075..23619273)

Chromosome 5 - NC_067378.1Genomic Context describing neighboring genes Neighboring gene dipeptidase 2 Neighboring gene dipeptidase 3 Neighboring gene DPEP2 neighbor Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T cells 3 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067378.1 Chromosome 5 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Names
dihydrouridine synthase 2-like, SMM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067378.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    23565075..23619273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051847216.1 → XP_051703176.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    UniProtKB/TrEMBL
    G1SYF8

  2. XM_008257495.3 → XP_008255717.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

    Conserved Domains (3) summary
    COG0042
    Location:212 → 516
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:571 → 635
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:215 → 454
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  3. XM_008257496.3 → XP_008255718.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

    Conserved Domains (3) summary
    COG0042
    Location:212 → 500
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:555 → 619
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:215 → 438
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  4. XM_017342312.2 → XP_017197801.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

  5. XM_017342313.2 → XP_017197802.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

  6. XM_051847210.1 → XP_051703170.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

  7. XM_051847212.1 → XP_051703172.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

  8. XM_008257498.3 → XP_008255720.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    See identical proteins and their annotated locations for XP_008255720.1

    UniProtKB/TrEMBL
    A0A5F9CGF6, G1SYF8
    Related
    ENSOCUP00000008651.2
    Conserved Domains (3) summary
    COG0042
    Location:10 → 314
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:369 → 433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  9. XM_051847208.1 → XP_051703168.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

  10. XM_051847213.1 → XP_051703173.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    UniProtKB/TrEMBL
    G1SYF8

  11. XM_051847209.1 → XP_051703169.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

  12. XM_008257497.3 → XP_008255719.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    See identical proteins and their annotated locations for XP_008255719.1

    UniProtKB/TrEMBL
    A0A5F9CGF6, G1SYF8
    Conserved Domains (3) summary
    COG0042
    Location:10 → 314
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:369 → 433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  13. XM_008257500.3 → XP_008255722.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    See identical proteins and their annotated locations for XP_008255722.1

    UniProtKB/TrEMBL
    A0A5F9CGF6, G1SYF8
    Conserved Domains (3) summary
    COG0042
    Location:10 → 314
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:369 → 433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  14. XM_051847214.1 → XP_051703174.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    UniProtKB/TrEMBL
    G1SYF8

  15. XM_051847211.1 → XP_051703171.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

  16. XM_051847215.1 → XP_051703175.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X6

    UniProtKB/TrEMBL
    G1SYF8
Nucleotide Protein
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