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Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B [ Mus musculus (house mouse) ]

Gene ID: 100340, updated on 27-Feb-2024

Summary

Official Symbol
Smpdl3bprovided by MGI
Official Full Name
sphingomyelin phosphodiesterase, acid-like 3Bprovided by MGI
Primary source
MGI:MGI:1916022
See related
Ensembl:ENSMUSG00000028885 AllianceGenome:MGI:1916022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asml3b; 1110054A24Rik
Summary
Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 61.1), duodenum adult (RPKM 49.2) and 7 other tissues See more
Orthologs
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Genomic context

See Smpdl3b in Genome Data Viewer
Location:
4 D2.3; 4 65.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132460277..132484558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132732966..132757171, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene EYA transcriptional coactivator and phosphatase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene X-linked Kx blood group related 8 Neighboring gene STARR-positive B cell enhancer ABC_E426 Neighboring gene STARR-positive B cell enhancer ABC_E6229 Neighboring gene replication protein A2 Neighboring gene thymocyte selection associated family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2125 Neighboring gene STARR-positive B cell enhancer ABC_E4675

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoric diester hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acid sphingomyelinase-like phosphodiesterase 3b
Names
ASM-like phosphodiesterase 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133888.2NP_598649.1  acid sphingomyelinase-like phosphodiesterase 3b precursor

    See identical proteins and their annotated locations for NP_598649.1

    Status: PROVISIONAL

    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18733.1
    UniProtKB/Swiss-Prot
    P58242
    UniProtKB/TrEMBL
    Q3TLX9
    Related
    ENSMUSP00000030709.9, ENSMUST00000030709.9
    Conserved Domains (2) summary
    cd00842
    Location:23323
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:22281
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132460277..132484558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163553.1XP_036019446.1  acid sphingomyelinase-like phosphodiesterase 3b isoform X1

    Conserved Domains (1) summary
    cd00842
    Location:23323
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain