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rims1a regulating synaptic membrane exocytosis 1a [ Danio rerio (zebrafish) ]

Gene ID: 100149357, updated on 18-Sep-2024

Summary

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Official Symbol
rims1aprovided by ZNC
Official Full Name
regulating synaptic membrane exocytosis 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090312-135
See related
Ensembl:ENSDARG00000074680 AllianceGenome:ZFIN:ZDB-GENE-090312-135
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-14m15.1
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in calcium ion-regulated exocytosis of neurotransmitter; modulation of chemical synaptic transmission; and regulation of membrane potential. Predicted to act upstream of or within exocytosis and intracellular protein transport. Predicted to be located in membrane and synapse. Predicted to be active in cytoskeleton of presynaptic active zone and presynaptic membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (27632629..27767395, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (27502180..27637072, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487404 Neighboring gene uncharacterized LOC110440184 Neighboring gene potassium voltage-gated channel, KQT-like subfamily, member 5a Neighboring gene asparaginase and isoaspartyl peptidase 1 Neighboring gene microRNA 30e-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptional inhibition of TCDD-mediated induction of cytochrome P450 1A1 and alteration of protein expression in a zebrafish hepatic cell line following the administration of TCDD and Cd(2). Chen YY, et al. Toxicol Lett, 2018 Jan 5. PMID 29107029
  2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
regulating synaptic membrane exocytosis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    27632629..27767395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213054.1 → XP_068069155.1  regulating synaptic membrane exocytosis protein 1 isoform X2

  2. XM_068213057.1 → XP_068069158.1  regulating synaptic membrane exocytosis protein 1 isoform X4

  3. XM_068213066.1 → XP_068069167.1  regulating synaptic membrane exocytosis protein 1 isoform X13

  4. XM_068213063.1 → XP_068069164.1  regulating synaptic membrane exocytosis protein 1 isoform X10

  5. XM_068213060.1 → XP_068069161.1  regulating synaptic membrane exocytosis protein 1 isoform X7

  6. XM_068213062.1 → XP_068069163.1  regulating synaptic membrane exocytosis protein 1 isoform X9

  7. XM_068213055.1 → XP_068069156.1  regulating synaptic membrane exocytosis protein 1 isoform X3

  8. XM_068213065.1 → XP_068069166.1  regulating synaptic membrane exocytosis protein 1 isoform X12

    Related
    ENSDARP00000152045.1, ENSDART00000189911.1

  9. XM_068213064.1 → XP_068069165.1  regulating synaptic membrane exocytosis protein 1 isoform X11

  10. XM_068213061.1 → XP_068069162.1  regulating synaptic membrane exocytosis protein 1 isoform X8

  11. XM_068213059.1 → XP_068069160.1  regulating synaptic membrane exocytosis protein 1 isoform X6

  12. XM_068213058.1 → XP_068069159.1  regulating synaptic membrane exocytosis protein 1 isoform X5

  13. XM_068213053.1 → XP_068069154.1  regulating synaptic membrane exocytosis protein 1 isoform X1

  14. XM_068213067.1 → XP_068069168.1  regulating synaptic membrane exocytosis protein 1 isoform X14

Nucleotide Protein Strain
Heading Accession and Version

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