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RIMS1 regulating synaptic membrane exocytosis 1 [ Homo sapiens (human) ]

Gene ID: 22999, updated on 4-Oct-2020

Summary

Official Symbol
RIMS1provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 1provided by HGNC
Primary source
HGNC:HGNC:17282
See related
Ensembl:ENSG00000079841 MIM:606629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIM; RIM1; CORD7; RAB3IP2
Summary
The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
Expression
Biased expression in brain (RPKM 5.2), testis (RPKM 1.0) and 4 other tissues See more
Orthologs

Genomic context

See RIMS1 in Genome Data Viewer
Location:
6q13
Exon count:
43
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (71886703..72403145)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (72596406..73112845)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene keratin 19 pseudogene 1 Neighboring gene RNA, U4 small nuclear 66, pseudogene Neighboring gene forkhead box H1 pseudogene Neighboring gene uncharacterized LOC107986611 Neighboring gene DNA polymerase delta 1, catalytic subunit pseudogene Neighboring gene HORMA domain containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available
Cone-rod dystrophy 7
MedGen: C1863634 OMIM: 603649 GeneReviews: Not available
Compare labs
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
GeneReviews: Not available
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-01-24)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2018-01-24)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0340, MGC167823, MGC176677

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosomal vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion regulated exocytosis TAS
Traceable Author Statement
more info
PubMed 
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
membrane fusion NAS
Non-traceable Author Statement
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulated exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neurotransmitter secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
secretion NAS
Non-traceable Author Statement
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 
presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
regulating synaptic membrane exocytosis protein 1
Names
RAB3-interacting protein 2
rab-3-interacting protein 2
rab3-interacting molecule 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016209.1 RefSeqGene

    Range
    4757..521196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168407.2NP_001161879.1  regulating synaptic membrane exocytosis protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001161879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
    Source sequence(s)
    AK294868, AK295001, AL035633, AL445256, BC036608
    Consensus CDS
    CCDS55030.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    Q3ZCW0
    Related
    ENSP00000385649.3, ENST00000401910.7
    Conserved Domains (3) summary
    cd04028
    Location:843988
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001168408.2NP_001161880.1  regulating synaptic membrane exocytosis protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001161880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
    Source sequence(s)
    AK295001, AL035633, BC036608
    Consensus CDS
    CCDS55029.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    Q3ZCW0
    Related
    ENSP00000428328.1, ENST00000523963.5
    Conserved Domains (3) summary
    cd04028
    Location:648793
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001168409.2NP_001161881.1  regulating synaptic membrane exocytosis protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001161881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
    Source sequence(s)
    AK295001, AK309185, AL035633, BC036608
    Consensus CDS
    CCDS55032.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    Q3ZCW0
    Related
    ENSP00000411235.2, ENST00000425662.6
    Conserved Domains (3) summary
    cd04028
    Location:591736
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001168410.2NP_001161882.1  regulating synaptic membrane exocytosis protein 1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001161882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
    Source sequence(s)
    AK295001, AK296303, AK308658, AK316108, AL035633, BC036608
    Consensus CDS
    CCDS55031.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    B7Z9Z3, Q3ZCW0
    Related
    ENSP00000428367.1, ENST00000517827.5
    Conserved Domains (3) summary
    cd04028
    Location:657802
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:201327
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:63148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. NM_001168411.2NP_001161883.1  regulating synaptic membrane exocytosis protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001161883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK295001, AK300853, AL035633, BC036608, DB168720
    Consensus CDS
    CCDS55033.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    Q3ZCW0
    Related
    ENSP00000402273.2, ENST00000414192.2
    Conserved Domains (1) summary
    cd04028
    Location:50195
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  6. NM_001350411.1NP_001337340.1  regulating synaptic membrane exocytosis protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL034373, AL390056, AL590011
  7. NM_001350412.1NP_001337341.1  regulating synaptic membrane exocytosis protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL390056, AL590011
    Conserved Domains (1) summary
    cl27627
    Location:54132
    UPF0004; Uncharacterized protein family UPF0004
  8. NM_001350413.1NP_001337342.1  regulating synaptic membrane exocytosis protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL034373, AL390056, AL590011
    Conserved Domains (1) summary
    cl27627
    Location:83159
    UPF0004; Uncharacterized protein family UPF0004
  9. NM_001350414.2NP_001337343.1  regulating synaptic membrane exocytosis protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:830975
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. NM_001350415.2NP_001337344.1  regulating synaptic membrane exocytosis protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:8621007
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:426633
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. NM_001350416.2NP_001337345.1  regulating synaptic membrane exocytosis protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:845990
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. NM_001350417.2NP_001337346.1  regulating synaptic membrane exocytosis protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:672817
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. NM_001350418.2NP_001337347.1  regulating synaptic membrane exocytosis protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:836981
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  14. NM_001350419.2NP_001337348.1  regulating synaptic membrane exocytosis protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:596741
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  15. NM_001350420.2NP_001337349.1  regulating synaptic membrane exocytosis protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:8811026
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  16. NM_001350421.2NP_001337350.1  regulating synaptic membrane exocytosis protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:796941
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  17. NM_001350422.2NP_001337351.1  regulating synaptic membrane exocytosis protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:671816
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25751
    Location:396612
    DUF4045; Domain of unknown function (DUF4045)
  18. NM_001350423.2NP_001337352.1  regulating synaptic membrane exocytosis protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:759904
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:345556
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  19. NM_001350424.2NP_001337353.1  regulating synaptic membrane exocytosis protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:625770
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  20. NM_001350425.2NP_001337354.1  regulating synaptic membrane exocytosis protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:829974
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  21. NM_001350426.2NP_001337355.1  regulating synaptic membrane exocytosis protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:621766
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:345552
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  22. NM_001350427.2NP_001337356.1  regulating synaptic membrane exocytosis protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:647792
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  23. NM_001350428.2NP_001337357.1  regulating synaptic membrane exocytosis protein 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:649794
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  24. NM_001350429.2NP_001337358.1  regulating synaptic membrane exocytosis protein 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:769914
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  25. NM_001350430.2NP_001337359.1  regulating synaptic membrane exocytosis protein 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:648793
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25751
    Location:373589
    DUF4045; Domain of unknown function (DUF4045)
  26. NM_001350431.2NP_001337360.1  regulating synaptic membrane exocytosis protein 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:8751020
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:347637
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  27. NM_001350432.2NP_001337361.1  regulating synaptic membrane exocytosis protein 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:617762
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  28. NM_001350433.2NP_001337362.1  regulating synaptic membrane exocytosis protein 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:8721017
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:345615
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  29. NM_001350434.2NP_001337363.1  regulating synaptic membrane exocytosis protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:697842
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  30. NM_001350435.2NP_001337364.1  regulating synaptic membrane exocytosis protein 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:826971
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25836
    Location:391569
    Retinal; Retinal protein
  31. NM_001350436.2NP_001337365.1  regulating synaptic membrane exocytosis protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:9071052
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  32. NM_001350437.2NP_001337366.1  regulating synaptic membrane exocytosis protein 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:824969
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15449
    Location:368579
    Retinal; Retinal protein
  33. NM_001350438.2NP_001337367.1  regulating synaptic membrane exocytosis protein 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (5) summary
    cd04028
    Location:732877
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:347663
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15449
    Location:531682
    Retinal; Retinal protein
  34. NM_001350439.2NP_001337368.1  regulating synaptic membrane exocytosis protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:820965
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  35. NM_001350440.2NP_001337369.1  regulating synaptic membrane exocytosis protein 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:620765
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:345551
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  36. NM_001350441.2NP_001337370.1  regulating synaptic membrane exocytosis protein 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:819964
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  37. NM_001350442.2NP_001337371.1  regulating synaptic membrane exocytosis protein 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (5) summary
    cd04028
    Location:733878
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:347664
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15449
    Location:532683
    Retinal; Retinal protein
  38. NM_001350443.2NP_001337372.1  regulating synaptic membrane exocytosis protein 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:810955
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  39. NM_001350444.2NP_001337373.1  regulating synaptic membrane exocytosis protein 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:768913
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:345556
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  40. NM_001350445.2NP_001337374.1  regulating synaptic membrane exocytosis protein 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:699844
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:345614
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  41. NM_001350446.2NP_001337375.1  regulating synaptic membrane exocytosis protein 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:9051050
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:347667
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  42. NM_001350447.2NP_001337376.1  regulating synaptic membrane exocytosis protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:792937
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:345580
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  43. NM_001350448.2NP_001337377.1  regulating synaptic membrane exocytosis protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:844989
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  44. NM_001350449.2NP_001337378.1  regulating synaptic membrane exocytosis protein 1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:641786
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25751
    Location:396582
    DUF4045; Domain of unknown function (DUF4045)
  45. NM_001350450.2NP_001337379.1  regulating synaptic membrane exocytosis protein 1 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:624769
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  46. NM_001350452.2NP_001337381.1  regulating synaptic membrane exocytosis protein 1 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (2) summary
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  47. NM_001350454.2NP_001337383.1  regulating synaptic membrane exocytosis protein 1 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:813958
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25836
    Location:391565
    Retinal; Retinal protein
  48. NM_001350455.2NP_001337384.1  regulating synaptic membrane exocytosis protein 1 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:597742
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  49. NM_001350456.2NP_001337385.1  regulating synaptic membrane exocytosis protein 1 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:9041049
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:347666
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  50. NM_001350457.2NP_001337386.1  regulating synaptic membrane exocytosis protein 1 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:823968
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  51. NM_001350458.2NP_001337387.1  regulating synaptic membrane exocytosis protein 1 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:846991
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  52. NM_001350459.2NP_001337388.1  regulating synaptic membrane exocytosis protein 1 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:797942
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  53. NM_001350460.2NP_001337389.1  regulating synaptic membrane exocytosis protein 1 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:803948
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:345574
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  54. NM_001350461.2NP_001337390.1  regulating synaptic membrane exocytosis protein 1 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:753898
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  55. NM_001350462.2NP_001337391.1  regulating synaptic membrane exocytosis protein 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:8581003
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  56. NM_001350463.2NP_001337392.1  regulating synaptic membrane exocytosis protein 1 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:738883
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  57. NM_001350464.2NP_001337393.1  regulating synaptic membrane exocytosis protein 1 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Related
    ENSP00000359448.4, ENST00000370420.8
    Conserved Domains (3) summary
    cd04028
    Location:739884
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  58. NM_001350465.2NP_001337394.1  regulating synaptic membrane exocytosis protein 1 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:567712
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  59. NM_001350466.2NP_001337395.1  regulating synaptic membrane exocytosis protein 1 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:740885
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  60. NM_001350467.2NP_001337396.1  regulating synaptic membrane exocytosis protein 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:712857
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:264500
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  61. NM_001350468.2NP_001337397.1  regulating synaptic membrane exocytosis protein 1 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Related
    ENSP00000389503.2, ENST00000453976.6
    Conserved Domains (4) summary
    cd04028
    Location:687832
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:264475
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  62. NM_001350469.2NP_001337398.1  regulating synaptic membrane exocytosis protein 1 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:763908
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  63. NM_001350470.2NP_001337399.1  regulating synaptic membrane exocytosis protein 1 isoform 64 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:659804
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:201327
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:63148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  64. NM_001350471.2NP_001337400.1  regulating synaptic membrane exocytosis protein 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (4) summary
    cd04028
    Location:790935
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:193319
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:55140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25836
    Location:368542
    Retinal; Retinal protein
  65. NM_001350472.2NP_001337401.1  regulating synaptic membrane exocytosis protein 1 isoform 66 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:632777
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:201327
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:63148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  66. NM_001350473.2NP_001337402.1  regulating synaptic membrane exocytosis protein 1 isoform 67 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Conserved Domains (3) summary
    cd04028
    Location:633778
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:201327
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:63148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  67. NM_001350474.2NP_001337403.1  regulating synaptic membrane exocytosis protein 1 isoform 68 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035633, AL445256, AL590011
    Related
    ENSP00000430359.1, ENST00000517433.5
    Conserved Domains (3) summary
    cd04028
    Location:754899
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:201327
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:63148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  68. NM_014989.6NP_055804.2  regulating synaptic membrane exocytosis protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055804.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL034373, AL035633, AL390056, AL445256, AL590011
    Consensus CDS
    CCDS47449.1
    UniProtKB/Swiss-Prot
    Q86UR5
    UniProtKB/TrEMBL
    B7Z7W2, Q3ZCW0
    Related
    ENSP00000428417.1, ENST00000521978.5
    Conserved Domains (6) summary
    cd04028
    Location:15231668
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191284
    DUF601; Protein of unknown function, DUF601
    cl25574
    Location:257536
    TOP2c; TopoisomeraseII
    cl28890
    Location:131186
    FYVE_like_SF; FYVE domain like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    71886703..72403145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010522.2XP_016866011.1  regulating synaptic membrane exocytosis protein 1 isoform X8

  2. XM_005248688.4XP_005248745.1  regulating synaptic membrane exocytosis protein 1 isoform X15

    Related
    ENSP00000264839.7, ENST00000264839.11
    Conserved Domains (4) summary
    cd04028
    Location:13461491
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:131186
    PHD_SF; PHD finger superfamily
  3. XM_017010519.2XP_016866008.1  regulating synaptic membrane exocytosis protein 1 isoform X5

  4. XM_011535604.3XP_011533906.2  regulating synaptic membrane exocytosis protein 1 isoform X9

  5. XM_017010527.2XP_016866016.1  regulating synaptic membrane exocytosis protein 1 isoform X17

    Related
    ENSP00000429959.1, ENST00000517960.5
    Conserved Domains (6) summary
    cd04028
    Location:13451490
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191284
    DUF601; Protein of unknown function, DUF601
    cl25574
    Location:257536
    TOP2c; TopoisomeraseII
    cl28890
    Location:131186
    FYVE_like_SF; FYVE domain like superfamily
  6. XM_017010517.2XP_016866006.1  regulating synaptic membrane exocytosis protein 1 isoform X3

  7. XM_017010523.2XP_016866012.1  regulating synaptic membrane exocytosis protein 1 isoform X10

  8. XM_017010520.2XP_016866009.1  regulating synaptic membrane exocytosis protein 1 isoform X6

  9. XM_024446371.1XP_024302139.1  regulating synaptic membrane exocytosis protein 1 isoform X14

    Conserved Domains (6) summary
    cd04028
    Location:13471492
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191284
    DUF601; Protein of unknown function, DUF601
    cl25574
    Location:257536
    TOP2c; TopoisomeraseII
    cl28890
    Location:131186
    FYVE_like_SF; FYVE domain like superfamily
  10. XM_017010516.2XP_016866005.1  regulating synaptic membrane exocytosis protein 1 isoform X2

  11. XM_017010521.2XP_016866010.1  regulating synaptic membrane exocytosis protein 1 isoform X7

  12. XM_017010525.2XP_016866014.1  regulating synaptic membrane exocytosis protein 1 isoform X13

  13. XM_017010526.2XP_016866015.1  regulating synaptic membrane exocytosis protein 1 isoform X16

  14. XM_024446369.1XP_024302137.1  regulating synaptic membrane exocytosis protein 1 isoform X1

    Conserved Domains (7) summary
    cd04028
    Location:14811626
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191284
    DUF601; Protein of unknown function, DUF601
    cl25574
    Location:257536
    TOP2c; TopoisomeraseII
    cl28033
    Location:8731189
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28890
    Location:131186
    FYVE_like_SF; FYVE domain like superfamily
  15. XM_017010518.2XP_016866007.1  regulating synaptic membrane exocytosis protein 1 isoform X4

  16. XM_024446370.1XP_024302138.1  regulating synaptic membrane exocytosis protein 1 isoform X11

    Conserved Domains (6) summary
    cd04028
    Location:13601505
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191284
    DUF601; Protein of unknown function, DUF601
    cl25574
    Location:257536
    TOP2c; TopoisomeraseII
    cl28890
    Location:131186
    FYVE_like_SF; FYVE domain like superfamily
  17. XM_017010524.2XP_016866013.1  regulating synaptic membrane exocytosis protein 1 isoform X12

  18. XM_017010546.2XP_016866035.1  regulating synaptic membrane exocytosis protein 1 isoform X21

  19. XM_017010537.2XP_016866026.1  regulating synaptic membrane exocytosis protein 1 isoform X18

  20. XM_024446372.1XP_024302140.1  regulating synaptic membrane exocytosis protein 1 isoform X19

    Conserved Domains (3) summary
    cd04028
    Location:8701015
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:216342
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:78163
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  21. XM_017010544.2XP_016866033.1  regulating synaptic membrane exocytosis protein 1 isoform X20

  22. XM_017010557.2XP_016866046.1  regulating synaptic membrane exocytosis protein 1 isoform X23

    Conserved Domains (1) summary
    cd04028
    Location:173318
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  23. XM_017010558.2XP_016866047.1  regulating synaptic membrane exocytosis protein 1 isoform X23

    Conserved Domains (1) summary
    cd04028
    Location:173318
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  24. XM_017010556.2XP_016866045.1  regulating synaptic membrane exocytosis protein 1 isoform X22

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