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TEN1 TEN1 subunit of CST complex [ Homo sapiens (human) ]

Gene ID: 100134934, updated on 21-Dec-2019

Summary

Official Symbol
TEN1provided by HGNC
Official Full Name
TEN1 subunit of CST complexprovided by HGNC
Primary source
HGNC:HGNC:37242
See related
Ensembl:ENSG00000257949 MIM:613130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf106
Summary
C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
Expression
Ubiquitous expression in small intestine (RPKM 13.6), fat (RPKM 12.7) and 25 other tissues See more
Orthologs

Genomic context

See TEN1 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75979240..76000586)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73975298..73996667)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10813 Neighboring gene Fas binding factor 1 Neighboring gene acyl-CoA oxidase 1 Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TEN1-CDK3

Readthrough gene: TEN1-CDK3, Included gene: CDK3

Homology

Clone Names

  • FLJ39785, MGC54300, DKFZp686C0493, DKFZp686G1463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
telomere capping TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CST complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CST complex IDA
Inferred from Direct Assay
more info
PubMed 
CST complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CST complex subunit TEN1
Names
TEN1 telomerase capping complex subunit homolog
TEN1, CST complex subunit
protein telomeric pathways with STN1 homolog
telomere length regulation protein TEN1 homolog
telomeric pathways in association with Stn1, number 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113324.3NP_001106795.2  CST complex subunit TEN1

    See identical proteins and their annotated locations for NP_001106795.2

    Status: VALIDATED

    Source sequence(s)
    BC047782
    Consensus CDS
    CCDS45780.2
    UniProtKB/Swiss-Prot
    Q86WV5
    Related
    ENSP00000380762.1, ENST00000397640.6
    Conserved Domains (1) summary
    pfam15490
    Location:3119
    Ten1_2; Telomere-capping, CST complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75979240..76000586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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