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CDK3 cyclin dependent kinase 3 [ Homo sapiens (human) ]

Gene ID: 1018, updated on 24-Nov-2020

Summary

Official Symbol
CDK3provided by HGNC
Official Full Name
cyclin dependent kinase 3provided by HGNC
Primary source
HGNC:HGNC:1772
See related
Ensembl:ENSG00000250506 MIM:123828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See CDK3 in Genome Data Viewer
Location:
17q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76000906..76005998)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73996235..74002080)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase 1 Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene TEN1 subunit of CST complex Neighboring gene envoplakin Neighboring gene signal recognition particle 68 Neighboring gene galanin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TEN1-CDK3

Readthrough gene: TEN1-CDK3, Included gene: TEN1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G0 to G1 transition TAS
Traceable Author Statement
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 3
Names
cell division protein kinase 3
NP_001249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258.3NP_001249.1  cyclin-dependent kinase 3

    See identical proteins and their annotated locations for NP_001249.1

    Status: VALIDATED

    Source sequence(s)
    AU146328, BU784937, BX098771, DB455174, X66357
    Consensus CDS
    CCDS11736.1
    UniProtKB/Swiss-Prot
    Q00526
    Related
    ENSP00000400088.1, ENST00000448471.2
    Conserved Domains (2) summary
    PLN00009
    Location:1293
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07860
    Location:3286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76000906..76005998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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