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SRA1 steroid receptor RNA activator 1 [ Homo sapiens (human) ]

Gene ID: 10011, updated on 12-Jul-2021

Summary

Official Symbol
SRA1provided by HGNC
Official Full Name
steroid receptor RNA activator 1provided by HGNC
Primary source
HGNC:HGNC:11281
See related
Ensembl:ENSG00000213523 MIM:603819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRA; SRAP; STRAA1; pp7684
Summary
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in adrenal (RPKM 15.0), testis (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See SRA1 in Genome Data Viewer
Location:
5q31.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (140550067..140558093, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139929652..139937678, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANKHD1-EIF4EBP3 readthrough Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene microRNA 6831 Neighboring gene solute carrier family 35 member A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87674

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables steroid receptor RNA activator RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid receptor RNA activator RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
NOT part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
steroid receptor RNA activator 1
Names
steroid receptor RNA activator 1 (complexes with NCOA1)
steroid receptor RNA activator protein
steroid receptor coactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031847.1 RefSeqGene

    Range
    5001..13027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001035235.4NP_001030312.3  steroid receptor RNA activator 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC011399, BC040043
    Consensus CDS
    CCDS34245.1
    Related
    ENSP00000337513.6, ENST00000336283.9
    Conserved Domains (1) summary
    pfam07304
    Location:71207
    SRA1; Steroid receptor RNA activator (SRA1)
  2. NM_001253764.2NP_001240693.1  steroid receptor RNA activator 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains a segment in the 5' coding region and lacks a downstream coding exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct segment in the N-terminal region, compared to isoform 1.
    Source sequence(s)
    AC011399, BC067895, BQ052761, BU553214
    Conserved Domains (1) summary
    pfam07304
    Location:103191
    SRA1; Steroid receptor RNA activator (SRA1)

RNA

  1. NR_045586.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF318361, AI140060, BC040043, BQ052761, DQ286291
  2. NR_045587.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) retains a segment in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011399, BC040043, BC067895, BQ052761, DA311407
    Related
    ENST00000602775.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    140550067..140558093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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