U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sra1 steroid receptor RNA activator 1 [ Mus musculus (house mouse) ]

Gene ID: 24068, updated on 5-Mar-2024

Summary

Official Symbol
Sra1provided by MGI
Official Full Name
steroid receptor RNA activator 1provided by MGI
Primary source
MGI:MGI:1344414
See related
Ensembl:ENSMUSG00000006050 AllianceGenome:MGI:1344414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sra; Srap; Straa1; Strra1
Summary
Enables DNA binding activity and nuclear receptor coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell leading edge. Part of transcription regulator complex. Is expressed in genitourinary system. Orthologous to human SRA1 (steroid receptor RNA activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 32.5), adrenal adult (RPKM 29.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sra1 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36800240..36803364, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36667187..36670311, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8708 Neighboring gene Riken cDNA E230025N22 gene Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene solute carrier family 35, member A4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of steroid hormone aporeceptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
steroid receptor RNA activator 1
Names
steroid receptor RNA activator protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164406.1NP_001157878.1  steroid receptor RNA activator 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK010375, BQ748094, BY097874
    UniProtKB/Swiss-Prot
    Q80VJ2
    Conserved Domains (1) summary
    pfam07304
    Location:78130
    SRA1; Steroid receptor RNA activator (SRA1)
  2. NM_025291.3NP_079567.2  steroid receptor RNA activator 1 isoform a

    See identical proteins and their annotated locations for NP_079567.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK010375, BQ748094, BY097874
    Consensus CDS
    CCDS29156.2
    UniProtKB/TrEMBL
    A0A8Q0Q6H9, G3X8R2
    Related
    ENSMUSP00000133360.2, ENSMUST00000173875.9
    Conserved Domains (1) summary
    pfam07304
    Location:78215
    SRA1; Steroid receptor RNA activator (SRA1)

RNA

  1. NR_028355.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK010375, BQ748094, BX516162, BY097874
    Related
    ENSMUST00000173482.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36800240..36803364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)