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Rcc1 regulator of chromosome condensation 1 [ Mus musculus (house mouse) ]

Gene ID: 100088, updated on 31-Jan-2019

Summary

Official Symbol
Rcc1provided by MGI
Official Full Name
regulator of chromosome condensation 1provided by MGI
Primary source
MGI:MGI:1913989
See related
Ensembl:ENSMUSG00000028896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chc1; AI326872; 4931417M11Rik
Expression
Broad expression in testis adult (RPKM 56.4), CNS E11.5 (RPKM 14.8) and 15 other tissues See more
Orthologs

Genomic context

See Rcc1 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (132331919..132345750, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (131887838..131901577, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene small nucleolar RNA host gene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Snhg3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Ran GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Ran guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Ran guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
 
nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sulfate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of chromosome condensation
Names
chromosome condensation protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197082.1NP_001184011.1  regulator of chromosome condensation isoform 1

    See identical proteins and their annotated locations for NP_001184011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK076089, AK150610, CJ075381, CR516684
    Consensus CDS
    CCDS57303.1
    UniProtKB/TrEMBL
    Q3U6D2, Q6PFB2
    Related
    ENSMUSP00000030726.6, ENSMUST00000030726.12
    Conserved Domains (2) summary
    pfam00415
    Location:376427
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:187216
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_133878.3NP_598639.1  regulator of chromosome condensation isoform 2

    See identical proteins and their annotated locations for NP_598639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK076089, AK150610, CR516684
    Consensus CDS
    CCDS18723.1
    UniProtKB/Swiss-Prot
    Q8VE37
    UniProtKB/TrEMBL
    Q3U6D2
    Related
    ENSMUSP00000081271.4, ENSMUST00000084250.10
    Conserved Domains (3) summary
    COG5184
    Location:2419
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:363414
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:174203
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    132331919..132345750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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