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Rcc1 regulator of chromosome condensation 1 [ Mus musculus (house mouse) ]

Gene ID: 100088, updated on 13-Oct-2022

Summary

Official Symbol
Rcc1provided by MGI
Official Full Name
regulator of chromosome condensation 1provided by MGI
Primary source
MGI:MGI:1913989
See related
Ensembl:ENSMUSG00000028896 AllianceGenome:MGI:1913989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chc1; 4931417M11Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Predicted to act upstream of or within cell division. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; metanephros; reproductive system; and vibrissa. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 56.4), CNS E11.5 (RPKM 14.8) and 15 other tissues See more
Orthologs
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Genomic context

See Rcc1 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132059230..132073061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132331919..132345750, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene CRISPRi-validated cis-regulatory element for Rcc1 and Trnau1ap Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene small nucleolar RNA host gene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Snhg3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of chromosome condensation
Names
chromosome condensation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197082.1NP_001184011.1  regulator of chromosome condensation isoform 1

    See identical proteins and their annotated locations for NP_001184011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK076089, AK150610, CJ075381, CR516684
    Consensus CDS
    CCDS57303.1
    UniProtKB/TrEMBL
    Q3U6D2, Q6PFB2
    Related
    ENSMUSP00000030726.7, ENSMUST00000030726.13
    Conserved Domains (2) summary
    pfam00415
    Location:376427
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:187216
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_133878.3NP_598639.1  regulator of chromosome condensation isoform 2

    See identical proteins and their annotated locations for NP_598639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK076089, AK150610, CR516684
    Consensus CDS
    CCDS18723.1
    UniProtKB/Swiss-Prot
    Q3UDB6, Q8VE37
    UniProtKB/TrEMBL
    Q3U6D2
    Related
    ENSMUSP00000081271.5, ENSMUST00000084250.11
    Conserved Domains (3) summary
    COG5184
    Location:2419
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:363414
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:174203
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132059230..132073061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)