Format

Send to:

Choose Destination

MED6 mediator complex subunit 6 [ Homo sapiens (human) ]

Gene ID: 10001, updated on 1-Jun-2020

Summary

Official Symbol
MED6provided by HGNC
Official Full Name
mediator complex subunit 6provided by HGNC
Primary source
HGNC:HGNC:19970
See related
Ensembl:ENSG00000133997 MIM:602984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC33; NY-REN-28
Expression
Ubiquitous expression in lymph node (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See MED6 in Genome Data Viewer
Location:
14q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (70583221..70600690, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71050306..71067401, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370556 Neighboring gene ADAM metallopeptidase domain 20 Neighboring gene ADAM metallopeptidase domain 20 pseudogene Neighboring gene double homeobox A pseudogene 12 Neighboring gene keratin 18 pseudogene 7 Neighboring gene uncharacterized LOC101928075 Neighboring gene RNA, 7SL, cytoplasmic 77, pseudogene Neighboring gene tetratricopeptide repeat domain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED6 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed
tat The interaction of HIV-1 Tat with MED21 hypothetically induces the binding of Tat to MED6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 6
Names
CTD-2540L5.5
activator-recruited cofactor 33 kDa component
renal carcinoma antigen NY-REN-28

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284209.1NP_001271138.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001271138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK300460, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS61484.1
    UniProtKB/Swiss-Prot
    O75586
    Related
    ENSP00000413343.2, ENST00000430055.6
    Conserved Domains (1) summary
    pfam04934
    Location:13146
    Med6; MED6 mediator sub complex component
  2. NM_001284210.1NP_001271139.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

    See identical proteins and their annotated locations for NP_001271139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300460, AK304361, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS61483.1
    UniProtKB/Swiss-Prot
    O75586
    Related
    ENSP00000394502.2, ENST00000440435.2
    Conserved Domains (1) summary
    pfam04934
    Location:13139
    Med6; MED6 mediator sub complex component
  3. NM_001284211.1NP_001271140.1  mediator of RNA polymerase II transcription subunit 6 isoform 4

    See identical proteins and their annotated locations for NP_001271140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and differs in the 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300460, BM802752, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS73649.1
    UniProtKB/Swiss-Prot
    O75586
    UniProtKB/TrEMBL
    A0A087WYL7
    Related
    ENSP00000481920.1, ENST00000615788.4
    Conserved Domains (1) summary
    pfam04934
    Location:13139
    Med6; MED6 mediator sub complex component
  4. NM_005466.4NP_005457.2  mediator of RNA polymerase II transcription subunit 6 isoform 2

    See identical proteins and their annotated locations for NP_005457.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL357153, BC004106, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS9805.1
    UniProtKB/Swiss-Prot
    O75586
    Related
    ENSP00000256379.5, ENST00000256379.9
    Conserved Domains (1) summary
    pfam04934
    Location:13139
    Med6; MED6 mediator sub complex component

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    70583221..70600690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center