Similar studies for GEO DataSets (Select 200036133) - GEO DataSets

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Items: 19

Select item 2000361331.

Expression data from the Cancer Cell Line Encyclopedia (CCLE)

(Submitter supplied) The Cancer Cell Line Encyclopedia (CCLE) project is a collaboration between the Broad Institute, the Novartis Institutes for Biomedical Research and the Genomics Novartis Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models It consists of a compilation of gene expression, chromosomal copy number, and massively parallel sequencing data from nearly 1,000 human cancer cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15308
917 Samples

Download data: CEL

Series

Accession:: GSE36133

ID:: 200036133

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000361392.

SNP and Expression data from the Cancer Cell Line Encyclopedia (CCLE)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL15315 GPL15308
1864 Samples

Download data: CEL

Series

Accession:: GSE36139

ID:: 200036139

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000361383.

SNP array data from the Cancer Cell Line Encyclopedia (CCLE)

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL15315
947 Samples

Download data: CEL, TXT

Series

Accession:: GSE36138

ID:: 200036138

PubMed Full text in PMC Similar studies

Select item 2001080624.

Drug sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. GSE107918 GSE108061

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array; Expression profiling by array

Platforms:: GPL9128 GPL10558
90 Samples

Download data: IDAT, TXT

Series

Accession:: GSE108062

ID:: 200108062

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000310195.

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells

(Submitter supplied) Certain oncolytic viruses exploit activated Ras signalling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identified 10 human cancer cell lines (out of 16) with increased sensitivity to the anti-viral effects of IFN-α after treatment with the MEK inhibitor U0126, suggesting that the Ras/MEK pathway underlies their reduced sensitivity to IFN. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4487
Platform:: GPL6244
30 Samples

Download data: CEL

Series

Accession:: GSE31019

ID:: 200031019

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Select item 44876.

Ras/MEK inhibition effect on IFN-alpha treated cancer cell line: time course

Analysis of HT1080 cells treated with IFN-alpha, the Ras/MEK inhibitor U0126, or both for 6 or 12 hours. SKOV3 cells treated with IFN-alpha for 6 hours examined. HT1080 is moderately resistant to the anti-viral effects of IFN-alpha. MEK inhibition increases the sensitivity of HT1080 to IFN-alpha.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 agent, 2 cell line, 2 time sets

Platform:: GPL6244
Series:: GSE31019
30 Samples

Download data: CEL

DataSet

Accession:: GDS4487

ID:: 4487

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001488427.

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq

(Submitter supplied) Precision oncology requires the timely selection of effective drugs or drug combinations for individual patients. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity. Here we combine multiplexed drug perturbation in acute slice culture from freshly resected tumors with single-cell RNA sequencing (scRNA-seq) to profile transcriptome-wide drug responses in individual patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
43 Samples

Download data: TXT

Series

Accession:: GSE148842

ID:: 200148842

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000316258.

Gene Expression Patterns that Predict Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Cell Lines and Human Lung Tumors

(Submitter supplied) Global gene expression data were generated from cultured non small cell lung cancer cell lines (NSCLC), normalized using MAS 5.0, filtered and used to predict response of cells to EGFR inhibition

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
48 Samples

Download data: CEL

Series

Accession:: GSE31625

ID:: 200031625

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000196389.

Compounds profiling on MCF7

(Submitter supplied) The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
14 Samples

Download data: CEL

Series

Accession:: GSE19638

ID:: 200019638

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Select item 20001855210.

CDK inhibitors and flavopiridol profiling on A2780 and MCF7 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
35 Samples

Download data: CEL

Series

Accession:: GSE18552

ID:: 200018552

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001850411.

Flavopiridol profiling on A2780

(Submitter supplied) The effects of the CDK inhibitor Flavopiridol on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE18504

ID:: 200018504

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Select item 20001850112.

CDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line

(Submitter supplied) The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE18501

ID:: 200018501

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Select item 20001849813.

CDK inhibitor PHA-793887 profiling on A2780

(Submitter supplied) The effects of the CDK inhibitor PHA-793887 on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE18498

ID:: 200018498

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Select item 20001848614.

CDK inhibitors PHA-848125 and PHA-690509 profiling on A2780

(Submitter supplied) The effects of the CDK inhibitors PHA-848125 and PHA-690509 on the A2780 cell line were analysed by gene expression profiling.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE18486

ID:: 200018486

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Select item 20009083015.

Integrative proteogenomic characterization of colorectal cancer cell lines and primary tumors

(Submitter supplied) Integrative analysis of global RNASeq and proteomic data comparing human colorectal cancer (CRC) cell lines to primary tumors and normal tissues.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
44 Samples

Download data: TXT

Series

Accession:: GSE90830

ID:: 200090830

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009081416.

Exon array data for patient-matched primary and metastatic colorectal samples

(Submitter supplied) Samples were taken from surgically resected tumor specimens/metastases from patients with colorectal cancer. The expression profiles were determined using the Affymetrix GeneChip Human Exon 1.0 ST Array version 2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
10 Samples

Download data: CEL

Series

Accession:: GSE90814

ID:: 200090814

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Select item 20009529817.

Patient- and Cell Type-Specific Heterogeneity of Metformin Response.

(Submitter supplied) Most FDA approved drugs are not equally effective in all patients, suggesting that identification of biomarkers to predict responders to a chemoprevention agent will be needed to stratify patients and achieve maximum benefit. The goal of this study was to investigate both patient specific and cell-context specific heterogeneity of metformin response, using cancer cell lines fibroblast cell lines and induced pluripotent stem cells differentiated into lung epithelial lineages. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
58 Samples

Download data: CEL, XLS

Series

Accession:: GSE95298

ID:: 200095298

Select item 20006039518.

Chemical profiling of the genome with anti-cancer drugs defines target specificities

(Submitter supplied) Many anti-cancer drugs induce DNA breaks to eliminate tumor cells. The anthracycline topoisomerase II inhibitors can also evict histones. We performed a genome-wide high-resolution mapping of chemotherapeutic effects of various topoisomerase I and II inhibitors. We show that different drugs target different types of chromatin for induction of DNA damage and histone eviction. Topoisomerase inhibitors topotecan and etoposide similarly target transcriptionally active chromatin for DNA damage. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
17 Samples

Download data: BEDGRAPH

Series

Accession:: GSE60395

ID:: 200060395

PubMed Similar studies SRA Run Selector

Select item 20014515219.

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma.

(Submitter supplied) Cancer cells often undergo lineage switching during their natural progression and in response to therapy. Lung adenocarcinomas (LUADs) exhibit a variety of differentiation states accompanied by dysregulation of lineage-specific transcription factors such as NKX2-1. Loss of NKX2-1 in human and murine LUAD leads to invasive mucinous adenocarcinoma (IMA), a subtype of lung cancer that exhibits pulmonary to gastric transdifferentiation. more...