1IG0,3LM8,3S4Y,3MEL,3L8M,3CQ9,3IHK


Conserved Protein Domain Family
TPK_B1_binding
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smart00983: TPK_B1_binding 
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Thiamin pyrophosphokinase, vitamin B1 binding domain
Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis.
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Statistics
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PSSM-Id: 214953
Aligned: 106 rows
Threshold Bit Score: 40.6284
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IG0_A       234 GTLI----------EYD-P------------------QFRNtcignCGLLPIGEATlVKETRGLKWDVKNWPTSVVTGRV 284 baker's yeast
XP_002097954 245 GKHTiq------vpVDLvT------------------SQRW-----CSLMPVGSSAhNVTTTGLKWNLYHAQLEFGGMVS 295 Drosophila yakuba
XP_002808952 324 GNHVi--------qINL-N------------------AFQKg----CALLPIGGKC-KVKTEGLKYNLNYEYLSFDSLIS 371 Plasmodium falc...
YP_514128    108 lcnisiaknyqqkieiefidiysryffipkkfavsgvvGKM-----FSVMPFGYVE-NIYYNGLRYPLSGESLSIDTNTG 181 Francisella tul...
NP_966263    145 GITHf---------FSL-P------------------KNTK-----ISLLGI-PRA-QISTKGLKWELHLSNLAFPGKNS 189 Wolbachia endos...
XP_647116    247 GRKIi---------LAS-KdnlawllsstynhniicrSETK-----CSLIPLSSKAsQVTTSGLKWNLVKQSLNFGELIS 311 Dictyostelium d...
NP_001023024 161 GDSNl--------dVNL-Em-----------------TTKM-----CGIIPIVQKEtIVSSIGLKYEMENLALEFGKLIS 209 nematode
YP_166564    130 GATEvifhlpprleLDL-V------------------PDDV-----VSLFPLASVT--ARSEGLFWPLEGLHMAPDGQIG 183 Silicibacter po...
YP_613960    130 GAHEvvvhltasleLEL-Q------------------AGDV-----VSLFPLLPVS--GRSDGLEWPIDGLELSPLSRIG 183 Silicibacter sp...
YP_001929944 168 G--Ea--------rIEV-E------------------RGRQ-----ISIFSFSGSA--VTAEGLKWPLRNTTLP--ELWC 209 Porphyromonas g...

1IG0_A       285 SSsNRFVgd-nCCFIDTKDDI 304 baker's yeast
XP_002097954 296 TS-NTYAtefvQVETDANLIw 315 Drosophila yakuba
XP_002808952 372 SS-NEIIqneiKISndtpliw 391 Plasmodium falciparum 3D7
YP_514128    182 AR-NYATedkvEISYSSGDIL 201 Francisella tularensis subsp. holarctica LVS
NP_966263    190 CF-NRSLgnkvSVEVHSGICL 209 Wolbachia endosymbiont of Drosophila melanogaster
XP_647116    312 TS-NVSLdn--kVCVETSNPL 329 Dictyostelium discoideum AX4
NP_001023024 210 TS-NEVTt--sQVFLKSSSSL 227 nematode
YP_166564    184 TS-NRATgpvvIEAAGPG--L 201 Silicibacter pomeroyi DSS-3
YP_613960    184 TS-NRATgsirIEVDGPG-LL 202 Silicibacter sp. TM1040
YP_001929944 210 GTlNEAVs--dTIYLSSAAPL 228 Porphyromonas gingivalis ATCC 33277
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