2DK9,1RT8,5BVR,2EYI,6ANU,1WYM,1H67,1WYN,5L0O,1WYR,2D86,3JAL,1PXY,2E9K,6ICI,2D89,6ANU,1SJJ,2K3S,5BVR


Conserved Protein Domain Family
CH
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pfam00307: CH 
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Calponin homology (CH) domain
The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.
Links
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Statistics
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PSSM-Id: 425596
Aligned: 121 rows
Threshold Bit Score: 42.2738
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DK9_A      12 AGTQEELLRWCQEQTAGY-PGvhvSDLSSSWADGLALCALVYRL------------QPGLLEPselqGLGALEATAWALK 78   human
Q550R2       9 KVQEMAFTSWVNSVL-EKrGCdkiSDVSTDLSDGVKLIYFLESVsgkkfp-kkfdlEPKT-------RIMRVQNLHLAML 79   Dictyostelium di...
Q54HG2       8 IVQEKAFTAWVNSVL--DkRGekiSDVGKDLSDGVKLIFFLELIsskkfn-kkydfEPKA-------RINMIQNVALALK 77   Dictyostelium di...
P05095      22 ITQKKTFTAWCNSHL--RkLGssiEQIDTDFTDGIKLAQLLEVIsndpv--fkvnkTPKL-------RIHNIQNVGLCLK 90   Dictyostelium di...
Q9NRC6      54 QMQEKTFTKWINNVFQCGqAGikiRNLYTELADGIHLLRLLELIsgeal---pppsRGRL-------RVHFLENSSRALA 123  human
6ANU_a      57 AVQKKTFTKWVNSHL--ArVTcrvGDLYSDLRDGRNLLRLLEVLsgeil---pkptKGRM-------RIHCLENVDKALQ 124  human
Q96JQ2      32 NVQKRTFTRWINLHLEKCnPPlevKDLFVDIQDGKILMALLEVLsgrnl--lheykSSSH-------RIFRLNNIAKALK 102  human
Q9N4M4      23 KAQKNTFTRWINFHLEEHsSSgriEDLFEDIRDGVLLCHLIEVLtgealavhkgrvSK---------RVHHIANLTTALT 93   Caenorhabditis e...
Q9VDW6      12 HIQKKTFTKWINSHLI-DtQCtpvKDLFLDLRDGHRLLALLSTLtqt-------nlKPEKGRM----RVHHINNLNKVIT 79   fruit fly
NP_035812   31 DVQKKTFTKWINARF-SKsGKppiSDMFSDLKDGRKLLDLLEGLtgts----lpkeRGST-------RVHALNNVNRVLQ 98  

2DK9_A      79 VAEnELGITPVV-SAQAVVAgSDPLGLIAYLSHFHSAFKS 117  human
Q550R2      80 FIDeDLKIKVQGvAAEEFVD-NNKKMILGFLWTLYRKYRI 118  Dictyostelium discoideum
Q54HG2      78 FLDeELKIKVQGiGSEDFVD-NNKKMILGFLWTLYRKYRI 116  Dictyostelium discoideum
P05095      91 HIE-SHGVKLVGiGAEELVD-KNLKMTLGMIWTIILRFAI 128  Dictyostelium discoideum
Q9NRC6     124 FLRaKVPVPLI--GPENIVD-GDQTLILGLIWVIILRFQI 160  human
6ANU_a     125 FLK-EQKVHLENmGSHDIVD-GNHRLTLGLVWTIILRFQI 162  human
Q96JQ2     103 FLE-DSNVKLVSiDAAEIAD-GNPSLVLGLIWNIILFFQI 140  human
Q9N4M4      94 VLR-RRGLELINnNAADIAD-GNPRIVLGLIWQIILHFQI 131  Caenorhabditis elegans
Q9VDW6      80 EIQ-QHGVKLVNiSSDDIVG-GNAKLTLGLIWLIALEFNG 117  fruit fly
NP_035812   99 VLH-QNNVDLVNiGGTDIVD-GNPKLTLGLLWSIILHWQV 136
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