1TJT,1TJT,1AA2,5BVR,5BVR,2E9K,2D87,2D89,1WYP,1SH5,1WJO,1WYM,1AOA,2D86,1WYN,1PXY,1RT8,1RT8,1DXX,1WYR,5L0O,2VZC


Conserved Protein Domain Family
CH

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pfam00307: CH 
Click on image for an interactive view with Cn3D
Calponin homology (CH) domain
The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.
Statistics
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PSSM-Id: 333996
View PSSM: pfam00307
Aligned: 144 rows
Threshold Bit Score: 43.8052
Threshold Setting Gi: 20138865
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1TJT_A   136 SAKEGLLLWCQRKTAPY-RNvnvQNFH-TSWKDGLALCALIHRHRPDLIDYAKLr---kD-----DPIGNLNTAFEVAEk 205 human
P32599   535 MSDSQILKWAQDQVTKGgKNstiRSFKdQALSNAHFLLDVLNGIAPGYVDYDLVt---pGnt-eeERYANARLAISIAR- 609 Saccharomyces cerev...
P54680   502 IADADIVNWTNSKLSAAgKKq-iSGFKdSTISTGIPILDVIEAVRPGSVDPALVa---tSgs-aeDNLLNAKLAVSTAR- 575 Dictyostelium disco...
O61604   513 IIEKEIVQWVNNRLSEAgKQsqlRNFNdPAIADGKIVIDLIDAIKEGSINYELVr---tSgt-qeDNLANAKYAISMAR- 587 fruit fly
Q61233   516 VNDDIIVNWVNTTLKEAqKSssiASFKdPKISTSLPVLDLIDAIQPGSINYDLLk---tEnlddeEKLNNAKYAISMAR- 591 house mouse
Q6P698   514 IIDETIVQWVNETLTQAgKGt-iSGFKdGSISSSMPVLDLIDAIQPGSIRYDLLk---aEdltdeKKLNNAKYAISMAR- 588 zebrafish
Q63598   519 ATDDIIVNWVNGTLSEAgKStsiQSFKdKTISSSLAVVDLIDAIQPGCINYDLVk---tGnlteeDKHNNAKYAVSMAR- 594 Norway rat
Q9FKI0   514 ITDADILNWANRKVKRGgRTsqaDSFRdKNLSSGMFFLELLSAVEPRVVNWSLVt---nGet-eeDKKLNATYIISVAR- 588 thale cress
EMS64905 529 ITDADILNWANSKVKASgRTsrmESFKdKSLSNGVFFLELLSAVQPRVVNWKVVt---kGea-deEKKLNATYIISVAR- 603 Triticum urartu
1WJO_A     7 gnDDIIVNWVNRTLSEAgKStsiQSFKdKTISSSLAVVDLIDAIQPGCINYDLVksgnlTe---dDKHNNAKYAVSMARr 83  human
1TJT_A   206 YLDIPKMLDAEDIVNtpkPDEKAIMTYVSCFYHAFAG 242 human
P32599   610 KLGALIWLVPEDINE---VRARLIITFIASLMTLNK- 642 Saccharomyces cerevisiae S288c
P54680   576 KVGAVVFALPEDIVE---VKPKMVLTLFASLWQVEMT 609 Dictyostelium discoideum
O61604   588 KIGARVYALPEDITE---VKPKMVMTVFACMMALDYV 621 fruit fly
Q61233   592 KIGARVYALPEDLVE---VNPKMVMTVFACLMGKGMK 625 house mouse
Q6P698   589 KIGARVYALPEDLVE---VKPKMVMTVFACLMARGMR 622 zebrafish
Q63598   595 RIGARVYALPEDLVE---VKPKMVMTVFACLMGRGMK 628 Norway rat
Q9FKI0   589 KLGCSIFLLPEDIIE---VNQKMMLILAASIMYWSLQ 622 thale cress
EMS64905 604 KLGCSVFLLPEDIIE---VNQKMILTLTASIMYWSLL 637 Triticum urartu
1WJO_A    84 -IGARVYAlPEDLVE---VKPKMVMTVFACLMGRGMK 116 human
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