461686     3 NRKWMYIFIQFLLVSSIRSDDDVFEDDeeevt---kgsdDKEEFVPSlfvapKLSDKSTp------nFFDYFPVGSKIGl 73  Caenorhabditis elegans
24641501  11 atlsMLFASSLLLLSAVKAIDSDLEWDdfe------dvdVEDVQQEDvd--eKPTYKSPvidakkfhFADHFDDMEASTr 82  fruit fly
27151766   1 MRERIITFVSLLLVALLSFPSVSYCD--------------DQTILY-------ESFDEP------------FDG------ 41  thale cress
231683     1 MRQRQLFSVFLLLLAFVSFQKLCYCD--------------DQTVLY-------ESFDEP------------FDG------ 41  thale cress
543920     5 WLLCMLLVLGTAIVEAHDGHDDDVIDIeddlddvieeveDSKPDTTAppsspKVTYKAPvptg-evyFADSFDRGTLSG- 82  human
3121839    2 HFQAFWLCLGLLFISINAEFMDDDVETedfeen-seeidVNESELSS-----EIKYKTPqpig-evyFAETFDSGRLAG- 73  human
543923     1 MKYGKVSFLALLCSLYVRGSLADPESE-------------QEPLVFN-----PTEVKAP--------LVEQFQG--AWSe 52  fission yeast
19112985   1 MQTLLFYFFFINLIFAHDLNVKTYKP-------------CTIPSVFS------EQFTSE-------------D-IT--T- 44  fission yeast
115549     1 MKFSAYLWWLFLNLALVKGTSLLSNVT------------LAEDSFWEh----FQAYTNT------------KHLNq---- 48  baker's yeast
22832382   1 MAWKMLFAILLLLSAAKTGYLAPESENsve------dvqIEPGAIYgd---eKFAYKSPvidaekfyFADHFDDVEASRk 71  fruit fly

461686    74 TWIKSLAKKDDVDSDIAKYNGEWSIGAPT-KVSIEGDLGLIVKTKARHHAIAAKL--NTPFAFDA--NTFVVQYDIKFEE 148 Caenorhabditis elegans
24641501  83 RWVLSQAKKDDIADEISKYDGIWNWEPPQ-RMVWANDLGLVLKSKAKHAAIAAHL--HQPFDFKSe-KPLVVQYEITIQK 158 fruit fly
27151766  42 RWVVS---------EKAEYQGVWKHE----KSEGHDDYGLLVSEKAKKYGIVKELdvDEPLNLNE--GTVVLQYEARFQE 106 thale cress
231683    42 RWIVS---------KNSDYEGVWKHA----KSEGHEDYGLLVSEKARKYGIVKEL--DEPLNLKE--GTVVLQYEVRFQE 104 thale cress
543920    83 -WILSKAKKDDTDDEIAKYDGKWEVEEMK-ESKLPGDKGLVLMSRAKHHAISAKL--NKPFLFDT--KPLIVQYEVNFQN 156 human
3121839   74 -WVLSKAKKDDMDEEISIYDGRWEIEELK-ENQVPGDRGLVLKSRAKHHAISAVL--AKPFIFAD--KPLIVQYEVNFQD 147 human
543923    53 RWIPSHAKRFVNGIEEMSYVGEWTVEESSgPGALKGEAGLVMKDEAAHHAISYEF--DEPINEPE--KDLVVQYEVNPEE 128 fission yeast
19112985  45 -WRSRWR------APVNKDLGVWDLVEAP-GSHLRDEYGLITLKSNKPHILISNL--ENPTTRQSssVPIVLSFQVKPTK 114 fission yeast
115549    49 EWITSEAVNN---EGSKIYGAQWRLSQGR-LQGSAWDKGIAVRTGNAAAMIGHLL--ETPINVSEt-DTLVVQYEIKLDN 121 baker's yeast
22832382  72 RWVLSQAKKNDIADEIAKYDGIWNWESPQ-RIFWANDLGLVLKSKAKHAAIAAPF--RQPFDFKSn-KPLVVQYELTLQE 147 fruit fly

461686   149 GQECGGGYLKLLSE-GAEKDLANFQDKTA-YTIMFGPDKCG-ATGKVHLIFRYKNPINGTISEYHANQPTTIGSTYWDDH 225 Caenorhabditis elegans
24641501 159 GQECGGSYLKLLSAgKETEQLQTFNDKTP-YTIMFGPDKCG-KDVTIHFIFKHVNPINGTITEKHCNKPNNSFEEPFKDK 236 fruit fly
27151766 107 GLECGGAYLKYLRPqEAGWVPQGFDNDSP-YSIMFGPDKCG-ATNKVHFILKHKNPKSGEFVEHHLKFPPS---VPF-DM 180 thale cress
231683   105 GLECGGAYLKYLRPqEAGWTPQGFDSESP-YSIMFGPDKCG-GTNKVHFILKHKNPKSGEYVEHHLKFPPS---VPY-DK 178 thale cress
543920   157 GIECGGAYVKLLSK-TPELNLDQFHDKTP-YTIMFGPDKCG-EDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDK 233 human
3121839  148 GIDCGGAYIKLLAD-TDDLILENFYDKTS-YIIMFGPDKCG-EDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDR 224 human
543923   129 GLNCGGAYLKLLAEpTHGEMSNSID-----YRIMFGPDKCG-VNDRVHFIFKHKNPLTGEYSEKHLDSRPASLLKPG--- 199 fission yeast
19112985 115 PWTCGHAYVSLVHQ----SNPKNVSKEPP-SVIRFGVKKCG----MFDYISLSIISYDGKVSCHLYDAPPS----GLVEG 181 fission yeast
115549   122 SLTCGGAFIKLMSGfMNVEALKHYAPDTEgVELVFGPDYCApEINGVQFAINKVDKITHESKLRYLQEMPLS--KLTDTS 199 baker's yeast
22832382 148 GQDCGGSYLKLLSAgKGTEQLNRFNDKTP-YTIMFGPDKCG-NNLKMHFIFRHVNPLNGNITEKHCKKPNARLGVPFTDK 225 fruit fly

461686   226 NTHLFTLVVKP-TGEYSVSVDGKSLYYGNMMS-----DVTPALTPPKQIFDETDLKPVDWDERENIEDESAVKPDDWDEN 299 Caenorhabditis elegans
24641501 237 LPHLYQLVVRP-DNSFEIRIDHKIIKEGSLLT-----DFKPPVNPPAEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDEN 310 fruit fly
27151766 181 LSHVYTAVLKS-DNEVRILVDGEEKKKGNLLSa---eDFEPPLIPSKTIPDPEDKKPEDWDERAKIPDPNAVKPDDWDED 256 thale cress
231683   179 LSHVYTAILKP-DNEVRILVDGEEKKKANLLSg---eDFEPALIPAKTIPDPEDKKPEDWDERAKIPDPNAVKPEDWDED 254 thale cress
543920   234 KTHLYTLILNP-DNSFEILVDQSVVNSGNLLN-----DMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDED 307 human
3121839  225 KTHLYTLVMNP-DDTFEVLVDQTVVNKGSLLE-----DVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDES 298 human
543923   200 ITNLYTLIVKP-DQTFEVRINGDVVRQGSLFY-----DFIPPVLPPVEIYDPEDIKPADWVDEPEIPDPNAVKPDDWDED 273 fission yeast
19112985 182 RTSMYTLLLQN--TTVVIRRDQSVVYTGDVGT-----NFFHSPTKWITHSNVSNGYYTSRNIMSFLLSNNTN-----TSS 249 fission yeast
115549   200 QSHLYTLIIDEsAQSFQILIDGKTVMVREHIEdkkkvNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDER 279 baker's yeast
22832382 226 LPHLYQLVVRP-DNSFEIRLDHKIIKEGSLLT-----DFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDED 299 fruit fly

461686   300 EPQSVVDEAATKPYDWNEEENELIADPEAKKPQDWDEDMDGSWEAPLIDNPACKGLSGCGTWKAPTIKNPKYKGKWIRPK 379 Caenorhabditis elegans
24641501 311 ETLKLPDadmifdp-------------tatkpeDWDDEIDGEWQAPMVDNPVCKKDQTCG-----IIRNPNYKGKWIAPM 372 fruit fly
27151766 257 APMEIEDEEAEKPEGWLDDEPVEVEDPEASKPEDWDDEEDGEWEAPKVSNTKCEAAPGCGEWKRPMKRNPAYKGKWSSPL 336 thale cress
231683   255 APMEIEDEEAEKPEGWLDDEPEEVDDPEATKPEDWDDEEDGMWEAPKIDNPKCEAAPGCGEWKRPMKRNPAYKGKWSSPL 334 thale cress
543920   308 APAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPM 387 human
3121839  299 EPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACR--IGCGEWKPPMIDNPKYKGVWRPPL 376 human
543923   274 APRMIPDPDAVKPEDWLEDEPLYIPDPEAQKPEDWDDEEDGDWIPSEIINPKCIEGAGCGEWKPPMIRNPNYRGPWSPPM 353 fission yeast
19112985 250 YPFSVNG---VELDVWNENAGVFINN----IYFGFSLSDAMKFENETFIAKKILENSPCP-------NQPSIQPFGILMM 315 fission yeast
115549   280 DPLMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLINNAKYKGPGELNE 359 baker's yeast
22832382 300 APPHLPDTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKGKWSAPM 379 fruit fly

461686   380 ISNPAFKGKWTARLIDNPNYFEPKPFA-GLAPITAVGIEMWT---MSENILFDNILITSSEEDSSDVAKQTFYVKqkeey 455 Caenorhabditis elegans
24641501 373 IDNPNYQGKWAPRKIANPDFFEDLKPF-QMTPISAVGLELWS---MSSDILFDNLIITDDVEVARDFAANSFDIKr---- 444 fruit fly
27151766 337 IDNPAYKGIWKPRDIPNPDYFELERP--NLEPIAAIGIEIWT---MQDGILFDNILISKDEKVAETYRQSTWKPK----- 406 thale cress
231683   335 IDNPAYKGIWKPRDIPNPDYFELDRP--DYEPIAAIGIEIWT---MQDGILFDNILIAKDEKVAETYRQTTWKPK----- 404 thale cress
543920   388 IDNPSYQGIWKPRKIPNPDFFEDLEPF-RMTPFSAIGLELWS---MTSDIFFDNFIICADRRIVDDWANDGWGLKk---- 459 human
3121839  377 VDNPNYQGIWSPRKIPNPDYFEDDHPF-LLTSFSALGLELWS---MTSDIYFDNFIICSEKEVADHWAADGWRWKi---- 448 human
543923   354 IPNPEFIGEWYPRKIPNPDYFDDDHPS-HFGPLYGVGFELWT---MQPNIRFSNIYVGHSIEDAERLGNETFLPK----- 424 fission yeast
19112985 316 LVSTIYGN--------FKNLYNCIKRN-TIGYIYNSIYDFWItegMLFPMRNMDIFKITAISIGLSIPVFLWLLK----- 381 fission yeast
115549   360 IINPNYMGEWHPPEIENPLYYEEQHPLrIENVISGVILEFWS---GSPNMLISNIYVGKNVTEAQIIGNKTWLMR----- 431 baker's yeast
22832382 380 IENPNNQGKWAPRKIANPDFFEDLKPF-QMTPINAVGLELWS---MSSDILFDNLIITDDVELARDFAANSFDIKr---- 451 fruit fly

461686   456 rlAAATGNGNgFFQQIIDATNEKPWLWAVYILCVLLPLVAIGVFCFGkqSKPTPNFAKKsda--ysADDDRVPNLVDDDE 533 Caenorhabditis elegans
24641501 445 --RYIDRERDsIVNKVVELVKDYPSIWAIGLVAIVALVA-LTKCCRFgtTKIQESAAAEs-----kKTDDPQPHEP--RP 514 fruit fly
27151766 407 --FDVEKEKQkAEDEAAGEADGLKS-YQKKVFDLLYKVADISFLSAY---KSKIMELIE-------KAE-TQPNLTIGVL 472 thale cress
231683   405 --FDVEKEKQkAEEEAAGSADGLKS-YQKVVFDLLNKVADLSFLSAY---KSKITELIE-------KAE-QQPNLTIGVL 470 thale cress
543920   460 --AADGAAEPgVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCS--GKKQTSGMEYk------KTDAPQPDVK--EE 527 human
3121839  449 --MIANANKPgVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPrkVKKKHKDTEYk------KTDICIPQTKGVLE 520 human
543923   425 --LKAERELL-SKQESMEKQSMHVDEESNQILEKFLDVYDIIKAKLPpnVAEKVDYYVE--------TIIETPEIGIAIV 493 fission yeast
19112985     --------------------------------------------------------------------------------     fission yeast
115549   432 -----------DRAFRGSDGPTERKFMNSRLGNLQTTFHNERESPNP---FDRIIDRIL-----------EQPLKFVLTA 486 baker's yeast
22832382 452 --LYIDRES--FGNKVVELARANRAIWGIVIVAIAVPVA-ITIFCKFglGPSRVAAAKKaaaaaakKTDDPQPDDD--LG 524 fruit fly

461686   534 EEII---------------------------------GDe---EDDVNQ-----------------------PGPSGSqs 554 Caenorhabditis elegans
24641501 515 WGSR---------------------------------MS----RAKKWK-----------------------LTIPPR-- 532 fruit fly
27151766 473 ISIV---------------------------------IVf---LSLFFK-----------------------LIFGG--- 490 thale cress
231683   471 VAIV---------------------------------VVf---FSLFLK-----------------------LIFGGK-- 489 thale cress
543920   528 EEEK---------------------------------EE----EKDKGD-----------------------EEEEGEek 547 human
3121839  521 QEEK---------------------------------EEkaalEKPMDL-----------------------EEEKKQnd 544 human
543923   494 AVLG---------------------------------SLtaviLTCYFY-----------------------FFASSSp- 516 fission yeast
19112985     --------------------------------------------------------------------------------     fission yeast
115549   487 AVVL---------------------------------LT----TSVLCC-----------------------VVFT---- 502 baker's yeast
22832382 525 AEEEeklekgkkeeekkeeeeeeekeenkeekkeeekDD----EKEMKDceeeeddeekddeektderaagdTNKEST-- 598 fruit fly

461686   555 npepqDEEENAEQQSANSsqssaAEEEDDEHVVPEnepvkptEEFAKKSpkn---tggAKrRTARRG 618 Caenorhabditis elegans
24641501 533 -----RAYSCPLPPKKK------LDDNEWKFKAAKk------QKHTQT----------KE--SNTEE 570 fruit fly
27151766 491 ------AKAKVEKKKPETa----AETSTSEAKTEEk------aEAVAAP---------RK-RQTRRE 531 thale cress
231683   490 -----KAAAPVEKKKPEv-----AESSKSGDEAEKk-------EETAAP---------RK-RQPRRD 529 thale cress
543920   548 ----lEEKQKSDAEEDGG-----TVSQEEEDRKPK-------AEEDEILnr------sPRnRKPRRE 592 human
3121839  545 g-emlEKEEESEPEEKSEeeieiIEGQEESNQSNKsgsedemKEADESTgsgdgpiksVRkRRVRKD 610 human
543923   517 ----aSLSTGTTEAEKEQ-----QEKFKQETETEK-------IDVSYAPe--------TEsPTAKNE 559 fission yeast
19112985     -------------------------------------------------------------------     fission yeast
115549       -------------------------------------------------------------------     baker's yeast
22832382 599 -----PLSASPKKNQKSY-----LDNNEDEEDTLKn------KEPTPk----------KRkRKALKE 639 fruit fly