4PJ3,5MQF,3JB9


Conserved Protein Domain Family
EEXXQc_AQR

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cd17935: EEXXQc_AQR 
Click on image for an interactive view with Cn3D
EEXXQ-box helicase domain of AQR
Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350693
Aligned: 20 rows
Threshold Bit Score: 249.266
Created: 19-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingDEAD box
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:4PJ3; Homo sapiens Aquarius with bound Mg.AMP-PNP, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ####  #                  #######                             #               
4PJ3_A        779 RNTIQFTHTQIEAIRAGXQPGLTXVVGPPGTGKTDVAVQIISNIYHNfPEQRTLIVTHSNQALNQLFEKIXALdiderHL 858  human
CAZ80093      800 SNHIKFTPTQVEAIRSGTNPGLTVIVGPPGTGKTDVATQIISNLYHNfPAQRTLLIAHSNQALNQLFEKITALdiderHL 879  Tuber melanos...
CBK23352      716 KPTVEFTPRQIEAIRSGMEPGLTMIVGPPGTGKTDVAVQIVSNLYHSyPDQRILLVTRSNHALNDLFVKIAQRdiekrHL 795  Blastocystis ...
CAB60444      801 KNQVKFTPSQVEAIKSGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNwPNQRTLIVTHSNQALNQLFEKIIALdvderHL 880  nematode
AEC09582      861 QNSVKFTPTQVGAIISGIQPGLTMVVGPPGTGKTDTAVQILNVLYHNcPSQRTLIITHSNQALNDLFEKIMERdvparYL 940  thale cress
EGG22171      865 QNKVEFTAAQAQAIIKGTREGLTLIQGPPGTGKTDVAVQIISNIYHNyPNQRTLIITHSNQALNQLFEKIYRLdiderYL 944  Dictyostelium...
CAK71822      660 VNNIRFTKPQINAIVSAMYPGLTLVVGPPGTGKTDVTVQLVNLLYKNfPNEKTLLITHSNHALNDIFQKISKMdvdekHM 739  Paramecium te...
CBY18240      787 TNSVPFTPTQIEAIRAGMQPGLSVIVGPPGTGKTDVAVQIISNIYHNfPEQRTVIVTHSNQALNQLFEKIMHLdiderHL 866  Oikopleura di...
EGD73730      835 RNAVPFTAAQVEAIHSGMQPGLTLVVGPPGTGKTDVAVQTISNLYHNhPDQRTLIVTHSNQALNQLFEKLIHLdieerHL 914  Salpingoeca s...
NP_001256831  801 KNQVKFTPSQVEAIKSGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNwPNQRTLIVTHSNQALNQLFEKIIALdvderHL 880  Caenorhabditi...
Feature 1                                                                                         
4PJ3_A        859 LRLGHGeeeletekdfsrygrvnyvlarrielleevkrlqkslgvpgdasytcetagyfflyqvxsrweeyiskvknkgs 938  human
CAZ80093      880 LRLGHGeeelktdtnyskqgrvesfmdnrvkllaevdrlaatlgapgahgdscetadyfnlvyvkpawaryqkvlseggl 959  Tuber melanos...
CBK23352      796 LRLGHGerdldstedfsrlgrvdyclqrrevllkavqqlavslgyledlgfscetsehfattvifpliqrylkvldhtcs 875  Blastocystis ...
CAB60444      881 LRMGHGeealetekdfsrygrvnyvlkerlqllncveklakalkivgdvaytcenagyffrfsvcrvweeflakvtskgc 960  nematode
AEC09582      941 LRLGQGeqelatdldfsrqgrvnamlvrrlellseverlarslqlpedvgytcetagyfwllhvysrwelflaacagne- 1019 thale cress
EGG22171      945 LRLGHGhkqlrlgsgnndnstepdftksgrieymvnlrqnrlqlvdylakslkvtsdvgytcetaghfyqhhiepmwnky 1024 Dictyostelium...
CAK71822      740 LRLGIGvkdlklsktfsregridhmlsrrlqlleivgkiqksvqimfseeyscevseiffklhiqrlwdnyrd------- 812  Paramecium te...
CBY18240      867 LRLGHGeemletekdfsrygrvnyvlqqrlallkevnrmqqslgvkgdvsytcetaghfylyqilsrwekfeeeiknfqe 946  Oikopleura di...
EGD73730      915 LRLGRGeellettkdfsrygrvdfvlqhrlelleevqrlaaslqypidvastcetcahfhrqaiqplwtayadrvqqqqq 994  Salpingoeca s...
NP_001256831  881 LRMGHGeealetekdfsrygrvnyvlkerlqllncveklakalkivgdvaytcenagyffrfsvcrvweeflakvtskgc 960  Caenorhabditi...
Feature 1                                                                                         
4PJ3_A        939 t--------------------------lpdvtevstffpfheyfanapqpifkgrsyeedxeiaegcfrhikkiftqlee 992  human
CAZ80093      960 ----------------------------aleklydsfpfhqyfsnapkpmfsqglsleeaievaeggyrhigklfteled 1011 Tuber melanos...
CBK23352      876 eeekaeltsiparysaekksqikewdaandteagrcfpfklffapqgsqlfasslsednlkergkrcmqtvqnlfnelke 955  Blastocystis ...
CAB60444      961 ----------------------------nklaegiiseifpftgffkdipdlfsgnnsadlkvahscwrhieqifeklde 1012 nematode
AEC09582     1020 ----------------------------dnqsfvrdrfpfkdffsdtpkpvfngesfekdmraakgcfshlktvfqelee 1071 thale cress
EGG22171     1025 ndqidkq-------------enkeqfivknfpfpdyfsvastkiffkspdsdemasleelkervermwtgvklvftelee 1091 Dictyostelium...
CAK71822      813 -----------------------------------kvqadpnvafpfntfveqnpllfekaqtreeqyrviedifeqvre 857  Paramecium te...
CBY18240      947 avle--------------------kkeefsvakignsfpfhvffanaaqplfkgedweedldiangcwwhiknifeqlee 1006 Oikopleura di...
EGD73730      995 hqleqk----------------qggdgsealamlaaefpfaaffstapqplfhgrsfdedwemalgcmrhlnhvfetlre 1058 Salpingoeca s...
NP_001256831  961 ----------------------------nklaegiiseifpftgffkdipdlfsgnnsadlkvahscwrhieqifeklde 1012 Caenorhabditi...
Feature 1                                                                                         
4PJ3_A        993 frasellrsgldrskyllvkeAKIIAXTCTHAALKRhdlvklgfkyDNILXEEAAQIleietfiplll-qnpqdgfsrlK 1071 human
CAZ80093     1012 irpfellktsrdrqnylltkeARIVAMTSTHAAMKRadiaklgfeyDNVVMEEAAQItevetfiplal-qsprggelplQ 1090 Tuber melanos...
CBK23352      956 yrafellrnwkhrtdyiltnqARIIAMTCTHAAIARqrflesnfkfDTIIFEEAAQMlelesfipfllqeasemepcqlK 1035 Blastocystis ...
CAB60444     1013 frafellrngrdrteyllvkeAKIIAMTCTHAALRRnelvklgfryDNIVMEEAAQIlevetfiplll-qnpqdghnrlK 1091 nematode
AEC09582     1072 crafellkstadranylmtkqAKIVAMTCTHAALKRrdflqlgfkyDNLLMEESAQIleietfipmll-qrqedgharlK 1150 thale cress
EGG22171     1092 crilellkspsdrfnylllkqSRIVAMTCTHASLKRaelvrlgfkfDNVLMEEAAQIsdiesfiplqlqstqfseknrlK 1171 Dictyostelium...
CAK71822      858 crpfellrnkkergnyiichqAKIVAMTCTHAALKRnsfceqdfqyDNIVFEEAGQIleieaflpl-----tmsltgklK 932  Paramecium te...
CBY18240     1007 frafellrtgldrtryllvkeAKIIAMTCTHAALKRkelvelgfkfDNIIMEESAQIleietfiplll-qnpedgfnrlK 1085 Oikopleura di...
EGD73730     1059 yrpfeqvhrgrdrskylltkeAKIVAMTCTHAALTRselvklgfkyDNVVMEEAAQIlevetfiplml-qntedgynrlK 1137 Salpingoeca s...
NP_001256831 1013 frafellrngrdrteyllvkeAKIIAMTCTHAALRRnelvklgfryDNIVMEEAAQIlevetfiplll-qnpqdghnrlK 1091 Caenorhabditi...
Feature 1                                                        ##              
4PJ3_A       1072 RWIXIGDHHQLPPviknxafqkysnxeqSLFTRFVrvgVPTVDLDAQGRarASLCNLYNWRYK 1134 human
CAZ80093     1091 RVVLCGDHYQNSPivqniafrqyanleqSLFARLVrlgAPTVNLDQQGRarASISRLYNWRYR 1153 Tuber melanosporum
CBK23352     1036 RVIYLGDANQLPPiihspllahatnldqSLFARLLrlgVPFVQLDAQGRsrDSIAALFAWRYE 1098 Blastocystis hominis
CAB60444     1092 RWIMIGDHHQLPPvvqnqafqkysnmeqSLFARLVrlsVPNVQLDRQGRarAQIAELYQWRYN 1154 nematode
AEC09582     1151 RCILIGDHHQLPPvvknmafqkyshmdqSLFTRFVrlgIPYIELNAQGRarPSLAKLYNWRYR 1213 thale cress
EGG22171     1172 RLIMIGDHQQLPPvvknaalakfshldqSLFARFVrlgVPYVVLDRQGRsrSQISQLYKWRYN 1234 Dictyostelium fasciculatum
CAK71822      933 RLIMIGDHNQLPPviknvsfqklanmeqSFFIRMIrlgVFYHQLTDQGRtrPEIMKLYSWKYK 995  Paramecium tetraurelia
CBY18240     1086 RWIMIGDHHQLPPviknqafqkysnmeqSLFTRFVrlgVPIIQLDMQGRarPTICELYNWRYE 1148 Oikopleura dioica
EGD73730     1138 RVMLIGDHHQLPPvikntafkkfsnmeqSLFTRFVrlgVPHVLLDKQGRmrPSLANLFRWNYE 1200 Salpingoeca sp. ATCC50818
NP_001256831 1092 RWIMIGDHHQLPPvvqnqafqkysnmeqSLFARLVrlsVPNVQLDRQGRarAQIAELYQWRYN 1154 Caenorhabditis elegans

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