Conserved Protein Domain Family
CESA_CaSu_A2

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cd06437: CESA_CaSu_A2 
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex.
Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.
Statistics
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PSSM-Id: 133059
View PSSM: cd06437
Aligned: 12 rows
Threshold Bit Score: 383.199
Threshold Setting Gi: 182677282
Created: 6-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_927175     38 PLVTVQLPVFNElYVCRRLLAATCALDYPreaLHIQVLDDSTDEtvqllaaaieeqr--rlgfsiehlhrkeRHGFKAGA 115 Gloeobacter vio...
YP_591979     90 PRVTVQLPIFNEqYVIDRLVEAVCKLDYPkdkLDIQVLDDSTDEtvevarevverya--algnpisyihrtnRHGFKAGA 167 Acidobacteria b...
ZP_01050557   54 PLVTIQLPVYNElYVMERLLDNIALLDYPkekLEIQVLDDSTDEsfertknhierlk--nqgldikhvtredRSGFKAGA 131 Cellulophaga sp...
YP_002873     57 PVVTVQLPIFNEyYVVDRLIETTVALKYPkdkLEIQLLDDSTDEtveksrnlinhykslgfdihhlhrsgaeRTGHKAGA 136 Leptospira inte...
AAM61171     119 PMVLVQIPMYNEkEVCEQSIAAACKISWPsnrIIIQVLDDSTDPaskelvkkecdrws-kegvnitfeirdnRNGYKAGA 197 thale cress
NP_841383     74 PSVSVLLPVHNEsFVVERLIDAACRLRYPadlLEILVLDDSSDDtsrlararveqya--argvnirhvcrndRQGYKAGN 151 Nitrosomonas eu...
ABK77754      50 PSVTIQLPIYNEkYVAARLISAVCDMDYPkdrLRIMVLDDSDDDtvdmvggivkeyr--drglqiehvrrgtRRGYKAGA 127 Cenarchaeum sym...
CAL57811     170 PMVVIQLPMFNEtDVCVHAIECAREMEWPrskLLIQILDDSTCPetratieealevck-eqgvhtqyrwrsdRTGFKAGA 248 Ostreococcus tauri
ABD79100      89 PMVLVQIPMFNErEVYQLSIQAACGLSWPgdrMIIQVLDDSTDQttrdlvqmecqrwa-skginiryetrpnRKGYKAGA 167 Physcomitrella ...
XP_001620978   5 PFVTIQLPIFNEkYVVERLLHSVAALDYPkekLEVQVLDDSTDDsvietarlinkha--lsglnikhirrenRVGFKAGA 82  starlet sea ane...
ABG34548      99 PMVLVQIPMYNErEVYQLSIGAACALSWPsnrVIIQVLDDSTDLtikdlvemecqkwa-skginikyeirgnRNGYKAGA 177 loblolly pine
YP_001831428  64 PHVLIQIPVFNEaEMVAEALQAAAALQWPrdrLHIQLLDDSTDEtstiaqrivlnlr--aqgtdvlhlrradRSGYKAGA 141 Beijerinckia in...
Feature 1                           ###                                                          
NP_927175    116 LAAAtpla---ngeYIAIFDADFlpppdwlkr-alvhfadgrVGLVQTRWGHTNpgySLLTRLQALGIDgHFAVEQqarc 191 Gloeobacter vio...
YP_591979    168 LQEGmavc---kgeFIAIFDADFvppadflqk-cihhfaepeIGMVQTRWTHLNrnySFLTEVEAILLDgHFVLEHggrs 243 Acidobacteria b...
ZP_01050557  132 LKEGlkva---kgeYIAIFDADFlpepnwlqr-tvpyfkdrnIGVVQTRWGHINreySLLTRVQAFALDaHFTLEQvgrn 207 Cellulophaga sp...
YP_002873    137 LEAGmkva---rgeYIAIFDADFmpnpdflik-tvpyfddpqIGMVQVRWGHINadyNVLTKAQSFGIDgHFMIEQvarn 212 Leptospira inte...
AAM61171     198 LREGmrhsyvkqcdYVAIFDADFqpdpdflhrtvpflihnpkLALVQGRWEFVNagqCMMTRLQEMSLSyHFTIEQqvgs 277 thale cress
NP_841383    152 LAHGihqa---sgeFFAIFDADFvpppdfllk-tipyfrdpqLGFLQTGIGYENknkSFLTRFQAMEMG-HQQYVTvgls 226 Nitrosomonas eu...
ABK77754     128 LQHAmkst---dteYVAIFDADFippkeflrk-tlphfaradMGFVQCRWGHVNedySTITQAQALSLDfHFLIEQkaks 203 Cenarchaeum sym...
CAL57811     249 MHDAmddi--veydYVCVFDADFspdpdflmktvpwihsnnhVGFVQARWTYINsseNLLTRVQSISLNyHIRCEQfarf 326 Ostreococcus tauri
ABD79100     168 LRQGmkwpyvqtcdYVAIFDADFqpepeflqrtvpflvhnsdLALVQARWKFVNaneCLMTKMQEVSLNyHFSVEQrvgs 247 Physcomitrella ...
XP_001620978  83 LKEGlida---kgeFIVIFDADFvpkpnwlqe-tipyfknekVGVVQTRWGHINrnfSILTKIQAFALDaHFTLEQvgrn 158 starlet sea ane...
ABG34548     178 LKEGmkhsyvrecdYVVIFDADFqpdrdflsrtipflvhnpeLALVQARWKFVNadeCLMTRMQEMSLDyHFTVEQevgs 257 loblolly pine
YP_001831428 142 LAAGmarc---dapYVAIFDVDFrppsnwlravvpmliadkkAGFVQSRCEFSNyatNWLTRIQGLMMDaHYTMEQatry 218 Beijerinckia in...
Feature 1                                                                                      
NP_927175    192 angyyfnfNGTAGVWRKRAIEAGGGWQADTLAEDLDLsyrsqlAGWKAVYDGRIVAPAELPVSMAAYKMQQYRWAKGS 269 Gloeobacter viola...
YP_591979    244 rkgvffnfNGTAGMWRKQAIEEAGGWQHDTLTEDTDLsyraqvKGWRFKYLQDVECPAELPIEMTAFKTQQARWAKGL 321 Acidobacteria bac...
ZP_01050557  208 skghfinfNGTAGLWRKQCIEDAGNWEGDTLTEDLDLsyraqlKNWKFKYLEDVKTPAELPVVISAARSQQFRWNKGG 285 Cellulophaga sp. ...
YP_002873    213 gshlwmnfNGTAGIWKKECIIDSGGWEHDTLTEDFDLsyraemKGWKFRYFKDIECKAEIPAMISAYKSQQFRWCKGS 290 Leptospira interr...
AAM61171     278 stfaffgfNGTAGVWRISALNESGGWNDQTTVEDMDLavratlRGWKFLYIDDLKVKSELPCSFKALRSQQHRWTCGP 355 thale cress
NP_841383    227 eegdmaslSGSSCVWRKSCVEVLGGWNTSMVTEDVDLgyraqfGEWKYAYLRDVVSMSLLPESVSAFRVQRERWGRGL 304 Nitrosomonas euro...
ABK77754     204 nsrlfmnfNGTAGIWKRECIEDAGGWHTATLVEDLDLsyraqmKGWKCTFLPDVVIDAELPVQMNAAKRQQFRWAKGS 281 Cenarchaeum symbi...
CAL57811     327 sanlffnfNGTAGIWRRTCIVDSGGWNHRTTVEDLDLslrahlRGWKFIFLDDVTCLNEIPAQYDAYRKQQHRWSAGP 404 Ostreococcus tauri
ABD79100     248 atygffgfNGTAGVWRIRAMEEAGGWNDRTTVEDMDLavraslCGWKFVYIHDLEVKNELPSTFKAFRFQQHRWSCGP 325 Physcomitrella pa...
XP_001620978 159 sknhfinfNGTAGAWRKSCIIDAGNWESDTLTEDLDLsyraqlKKWQFVYLEDVETPAELPAVLSAARSQQFRWNKGG 236 starlet sea anemone
ABG34548     258 athaffgfNGTAGVWRIKALNEAGGWKDRTTVEDMDLavraslRGWKFVFVGDLGVKNELPSTFKAYRYQQHRWSCGP 335 loblolly pine
YP_001831428 219 ragwlfqfNGTAGLWRREAIEAAGGWSADSLCEDLDLtvrarvAGWHGVFTMEPVVPGLVPEKVRHWRVQQRRWSTGF 296 Beijerinckia indi...

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