5V3P,3ZRH


Conserved Protein Domain Family
OTU

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pfam02338: OTU 
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OTU-like cysteine protease
This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.
Statistics
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PSSM-Id: 426728
Aligned: 13 rows
Threshold Bit Score: 109.462
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5V3P_A  98 NGDGNXLMHATSQYMWgvqdtdlvLRKALFS---TLKETD-----TRNFKfrwql------------eslksQEFVETGL 157 human
3ZRH_A 195 RTAGDCLLDSVLQATW--------GIYDKDS---VLRKAL-----HDSLHdcshwfytrwkdweswysqsfgLHFSLREE 258 human
Q9VH90 513 RSAGDCLLDSAMQATWgvfdrdniLRR-------ALADTLhq--cGHVFFtrwk--------------eyemLQASMLHF 569 fruit fly
Q9N4T5 130 TGDGNCLLHAASLGMWgvhdrqlsLRE-------TLYELLtngarKEAIRrrwkw------------venhmNQSNGLAL 190 Caenorhabditis elegans
Q8I2S5  99 IGDGNCLFRSISRNLF--------HKQKYHM---YVRKKC-----VEYMI----------------------NYKEEYSI 140 Plasmodium falciparum...
Q8LBZ4 174 PGDGRCLFRSVAHGFClrsgklapGEKMQREladELRTRV-----ADEFI----------------------QRRQETEW 226 thale cress
Q9UUK3 191 PADGNCLFASISHQLNyh-----hNVKLNSQ---ALRNKS-----ADYVL----------------------KHCEQFEG 235 Schizosaccharomyces p...
P38747 173 QPDGHCLFASILDQLKlrhdpkklDQDMDVM---KLRWLS-----CNYVQ----------------------EHRDDFIP 222 Saccharomyces cerevis...
Q19681 173 PADGDCMYNAISHQLqe------eGIEISVR---KLRKRC-----GTYMR----------------------EHSEDFRP 216 Caenorhabditis elegans
Q9LYC7 187 KPDGHCLYRAVENQLAnrs---ggASPYTYQ---NLREMA-----ASYMR----------------------EHKTDFLP 233 thale cress
Q8N6M0 153 PSDGHCMYKAIEDQLke------kDCALTVV---ALRSQT-----AEYMQ----------------------SHVEDFLP 196 human
Q9VUN9 178 PSDGDCLYQSIRHQLIvn-----aLPGHSVQ---ELREET-----ANYVR----------------------AHKDSLIS 222 fruit fly
Q9CUB6 288 IPDGNCLYRAVSKTVY--------GDQSLHR---ELREQT-----VHYIA----------------------DHLDHFSP 329 house mouse
5V3P_A 158 CYDTR-------------------------NWNDewdnlikmastdt------pmarsglqynsleEIHIFVLCNILRRP 206 human
3ZRH_A 259 QWQEDwafils-------------lasqpgASLE--------------------------------QTHIFVLAHILRRP 293 human
Q9VH90 570 TLEDS-------------------------QFEEdwstllsla---------------gqpgssleQLHIFALAHILRRP 609 fruit fly
Q9N4T5 191 TLSEN-------------------------EWELewdvvlglssplprkqedngsnstdqiyesleAIHVFALAHVLKRP 245 Caenorhabditis elegans
Q8I2S5 141 YFENNefqqyik------------nmskngYWGD--------------------------------ELCIKATADAFDCI 176 Plasmodium falciparum...
Q8LBZ4 227 FVEGDfdtyvr-------------qirdphVWGG--------------------------------EPELFMASHVLQMP 261 thale cress
Q9UUK3 236 FLLDEesgevlpvsd------ycneirnnsKWGS--------------------------------DIEIQALANSLEVP 277 Schizosaccharomyces p...
P38747 223 YLFDEetmkmkdide------ytkemehtaQWGG--------------------------------EIEILALSHVFDCP 264 Saccharomyces cerevis...
Q19681 217 FIEDManmdsdsswaty-lggvenvaeiggVWGG--------------------------------ELELKACSMIFEKT 263 Caenorhabditis elegans
Q9LYC7 234 FFLSEtegdsnsgsaeerfekycrevestaAWGS--------------------------------QLELGALTHCLRKH 281 thale cress
Q8N6M0 197 FLTNPntgdmytpeef---qkycedivntaAWGG--------------------------------QLELRALSHILQTP 241 human
Q9VUN9 223 YMIHPetgdilndqqf---eqychdiakthAWGG--------------------------------HIELKAISSLLRVP 267 fruit fly
Q9CUB6 330 LIEGDvgefii-------------aaaqdgAWAG--------------------------------YPELLAMGQMLNVN 364 house mouse
5V3P_A 207 IIVisdkmLRSlESGSN---FAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHF 257 human
3ZRH_A 294 IIVygvkyYKS-FRGET---LGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHF 343 human
Q9VH90 610 IIVygvkyVKS-FRGED---IGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHF 659 fruit fly
Q9N4T5 246 VVVvsdtiLRN-AKGEE---LSPVAFGGIYLPLECPPSQCHRSPLVLCYDSAHF 295 Caenorhabditis elegans
Q8I2S5 177 IYI-------I-TSTLE---NWHLKYESKNNNGMYKKCVFLAYSS-----PTHY 214 Plasmodium falciparum 3D7
Q8LBZ4 262 ITV------YM-KDDKA---GGLISIAEYGQEYGKDDPIRVLYHG-----FGHY 300 thale cress
Q9UUK3 278 VHV-----YNT-EGPVL---KFNPSTVK------FEKPLCIAYYQHLFGLGAHY 316 Schizosaccharomyces pombe 972h-
P38747 265 ISI-----LMS-GRPI--------QVYN---ECGKNPELKLVYYKHSYALGEHY 301 Saccharomyces cerevisiae S288C
Q19681 264 IVV-----YKQ-YGGRH---TIG-EEYS----SPKDRALRVVFLRHAYSLGEHY 303 Caenorhabditis elegans
Q9LYC7 282 IKV-----YSG-SFPDV---EMG-KEYR----SGDDSSLMLSYHRHAFGLGEHY 321 thale cress
Q8N6M0 242 IEI-----IQA-DSPPI---IVG-EEYS-------KKPLILVYMRHAYGLGEHY 278 human
Q9VUN9 268 IEV-----IQA-EGAPT---LLGQEEFG-------GSPLIICYHRHIYQLGAHY 305 fruit fly
Q9CUB6 365 IHL-------T-TGGRLespTVSTMIHYLGPEDSLRPSIWLSWLS-----NGHY 405 house mouse
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