Sgo2 shugoshin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sgo2provided by RGD
Official Full Name: shugoshin 2provided by RGD
Primary source: RGD:1308450
See related: Ensembl:ENSRNOG00000027035 AllianceGenome:RGD:1308450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sgol2
Summary: Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Predicted to be located in condensed chromosome, centromeric region and nuclear body. Predicted to be part of mitotic cohesin complex. Predicted to be active in kinetochore. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 218.1), Spleen (RPKM 116.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (67032083..67067439)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (59548605..59573229)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (64898380..64923023)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of maintenance of meiotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in meiotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic sister chromatid cohesion involved in meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
part_of mitotic cohesin complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: shugoshin 2

Names: shugoshin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271191.3 → NP_001258120.1 shugoshin 2

See identical proteins and their annotated locations for NP_001258120.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

D3ZWI4

Conserved Domains (2) summary

pfam07558
Location:54 → 94

Shugoshin_N; Shugoshin N-terminal coiled-coil region

pfam07557
Location:1141 → 1162

Shugoshin_C; Shugoshin C terminus